Sequence in raw or FASTA format:
THPO thrombopoietin [Homo sapiens (human)]
|Entrez Gene ID||7066|
|Synonyms||MGDF, MKCSF, ML, MPLLG, THCYT1, TPO|
|General protein information||
|Organism||Homo sapiens (human)|
|Summary||Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5' UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent. [provided by RefSeq, Feb 2014].|
Thrombocythemia, essential, 187950 (3)
|hsa04640||Hematopoietic cell lineage|
|REACT_798||Platelet activation, signaling and aggregation|
|REACT_278||Platelet Aggregation (Plug Formation)|
|Homo sapiens (human)||THPO||NP_000451.1|
|Pan troglodytes (chimpanzee)||THPO||XP_001136518.2|
|Canis lupus familiaris (dog)||THPO||XP_005639837.1|
|Bos taurus (cattle)||THPO||NP_001159512.1|
|Mus musculus (house mouse)||Thpo||NP_033405.1|
|Rattus norvegicus (Norway rat)||LOC100910397||XP_006248642.1|
|Rattus norvegicus (Norway rat)||Thpo||NP_112395.1|
|GO:0001934||positive regulation of protein phosphorylation||ISS|
|GO:0007275||multicellular organismal development||TAS|
|GO:0030099||myeloid cell differentiation||IEA|
|GO:0038163||thrombopoietin-mediated signaling pathway||ISS|
|GO:0045654||positive regulation of megakaryocyte differentiation||ISS|
|GO:0051897||positive regulation of protein kinase B signaling||ISS|
|GO:0070374||positive regulation of ERK1 and ERK2 cascade||ISS|
|GO:0008083||growth factor activity||TAS|
|UniProt||Q5FBX8, P40225, F8W6L1|
What is the normal function of the THPO gene?
The THPO gene provides instructions for making a protein called thrombopoietin that promotes the growth and division (proliferation) of cells. This protein attaches to (binds) and turns on (activates) the thrombopoietin receptor, which stimulates several signaling pathways that transmit chemical signals from outside the cell to the cell's nucleus. These pathways are important for controlling the production of blood cells.
Thrombopoietin is especially important for the proliferation of certain blood cells called megakaryocytes, which produce platelets, the cells involved in blood clotting. Research suggests that thrombopoietin signaling may also play a role in the renewal of hematopoietic stem cells, which are stem cells located within the bone marrow that have the potential to develop into red blood cells, white blood cells, and platelets.
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