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THPO thrombopoietin [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000460 Homo sapiens thrombopoietin (THPO), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10
NM_001177597 Homo sapiens thrombopoietin (THPO), transcript variant 2, mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10
NM_001177598 Homo sapiens thrombopoietin (THPO), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_001289997 Homo sapiens thrombopoietin (THPO), transcript variant 4, mRNA. GenEZ ORF Cloning On-demand $449.00 14
NM_001289998 Homo sapiens thrombopoietin (THPO), transcript variant 5, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_001290003 Homo sapiens thrombopoietin (THPO), transcript variant 5, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_001290022 Homo sapiens thrombopoietin (THPO), transcript variant 6, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_001290026 Homo sapiens thrombopoietin (THPO), transcript variant 7, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_001290027 Homo sapiens thrombopoietin (THPO), transcript variant 8, mRNA. GenEZ ORF Cloning On-demand $449.00 14
NM_001290028 Homo sapiens thrombopoietin (THPO), transcript variant 9, mRNA. GenEZ ORF Cloning On-demand $549.00 14
XM_005247737 PREDICTED: Homo sapiens thrombopoietin (THPO), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_006713738 PREDICTED: Homo sapiens thrombopoietin (THPO), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_006713739 PREDICTED: Homo sapiens thrombopoietin (THPO), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand $699.00 18

*Business Day

Related Services

Gene Symbol THPO
Entrez Gene ID 7066
Full Name thrombopoietin
Synonyms MGDF, MKCSF, ML, MPLLG, THCYT1, TPO
General protein information
Preferred Names
thrombopoietin
Names
thrombopoietin
MPL ligand
c-mpl ligand
thrombopoietin nirs variant 1
megakaryocyte stimulating factor
megakaryocyte colony-stimulating factor
megakaryocyte growth and development factor
myeloproliferative leukemia virus oncogene ligand
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

3

3q27

Summary Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5' UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent. [provided by RefSeq, Feb 2014].
Disorder

MIM: 600044

Thrombocythemia, essential, 187950 (3)

mRNA Protein Product Sequence Price Select
NM_000460, 586798198 NP_000451, 4507493 thrombopoietin isoform 1 precursor ORF Sequence $269.00
NM_001177597, 586798209 NP_001171068, 294862250 thrombopoietin isoform 2 precursor ORF Sequence $269.00
NM_001177598, 586798163 NP_001171069, 294862252 thrombopoietin isoform 3 precursor ORF Sequence $400.00
NM_001289997, 586798190 NP_001276926, 586798191 thrombopoietin isoform 4 precursor ORF Sequence $300.00
NM_001289998, 586798207 NP_001276927, 586798208 thrombopoietin isoform 1 precursor ORF Sequence $400.00
NM_001290003, 586798192 NP_001276932, 586798193 thrombopoietin isoform 5 ORF Sequence $550.00
NM_001290022, 586798199 NP_001276951, 586798200 thrombopoietin isoform 2 precursor ORF Sequence $400.00
NM_001290026, 586798201 NP_001276955, 586798202 thrombopoietin isoform 3 precursor ORF Sequence $400.00
NM_001290027, 586798203 NP_001276956, 586798204 thrombopoietin isoform 4 precursor ORF Sequence $300.00
NM_001290028, 586798205 NP_001276957, 586798206 thrombopoietin isoform 1 precursor ORF Sequence $400.00
XM_005247737, 578807696 XP_005247794, 530375197 thrombopoietin isoform X1 ORF Sequence $550.00
XM_006713738, 578807692 XP_006713801, 578807693 thrombopoietin isoform X2 ORF Sequence $550.00
XM_006713739, 578807694 XP_006713802, 578807695 thrombopoietin isoform X3 ORF Sequence $550.00
KEGG
hsa04640Hematopoietic cell lineage
Reactome
REACT_798Platelet activation, signaling and aggregation
REACT_604Hemostasis
REACT_278Platelet Aggregation (Plug Formation)
Homo sapiens (human)THPONP_000451.1
Pan troglodytes (chimpanzee)THPOXP_001136518.2
Canis lupus familiaris (dog)THPOXP_005639837.1
Bos taurus (cattle)THPONP_001159512.1
Mus musculus (house mouse)ThpoNP_033405.1
Rattus norvegicus (Norway rat)LOC100910397XP_006248642.1
Rattus norvegicus (Norway rat)ThpoNP_112395.1
Process
IDNameEvidence
GO:0001934positive regulation of protein phosphorylationISS
GO:0007275multicellular organismal developmentTAS
GO:0007596blood coagulationTAS
GO:0008283cell proliferationIEA
GO:0030099myeloid cell differentiationIEA
GO:0030168platelet activationTAS
GO:0038163thrombopoietin-mediated signaling pathwayISS
GO:0045654positive regulation of megakaryocyte differentiationISS
GO:0051897positive regulation of protein kinase B signalingISS
GO:0070374positive regulation of ERK1 and ERK2 cascadeISS
Component
IDNameEvidence
GO:0005615extracellular spaceIEA
Function
IDNameEvidence
GO:0005125cytokine activityIEA
GO:0005179hormone activityIEA
GO:0008083growth factor activityTAS
GeneCards THPO
UniProt Q5FBX8, P40225, F8W6L1
Vega OTTHUMG00000156745
MIM 600044
Ensembl ENSG00000090534
HGNC 11795
HPRD 02500

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the THPO gene?

The THPO gene provides instructions for making a protein called thrombopoietin that promotes the growth and division (proliferation) of cells. This protein attaches to (binds) and turns on (activates) the thrombopoietin receptor, which stimulates several signaling pathways that transmit chemical signals from outside the cell to the cell's nucleus. These pathways are important for controlling the production of blood cells.

Thrombopoietin is especially important for the proliferation of certain blood cells called megakaryocytes, which produce platelets, the cells involved in blood clotting. Research suggests that thrombopoietin signaling may also play a role in the renewal of hematopoietic stem cells, which are stem cells located within the bone marrow that have the potential to develop into red blood cells, white blood cells, and platelets.

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