Search Tips

  • THAT   AND
  • THAT   AND


THPO thrombopoietin [Homo sapiens (human)]


RefSeq Accession Definition Sequence Price Select
NM_000460 Homo sapiens thrombopoietin (THPO), transcript variant 1, mRNA. Full Length $523.45
ORF Sequence $307.98
NM_001177598 Homo sapiens thrombopoietin (THPO), transcript variant 3, mRNA. Full Length $518.52
ORF Sequence $278.40
NM_001177597 Homo sapiens thrombopoietin (THPO), transcript variant 2, mRNA. Full Length $519.97
ORF Sequence $304.50


Gene Symbol THPO
Entrez Gene ID 7066
Full Name thrombopoietin
Synonyms MGC163194, MGDF, MKCSF, ML, MPLLG, TPO
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

3

3q27
Summary Megakaryocytopoiesis is the cellular development process that leads to platelet production. The protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Alternate splicing results in multiple transcript variants of this gene.
Disorder

MIM: 600044

Thrombocythemia, essential, 187950 (3)
mRNA NM_000460, 40805871
Protein NP_000451, 4507493
Product thrombopoietin isoform 1 precursor
RefSeq Status REVIEWED
mRNA NM_001177598, 294862251
Protein NP_001171069, 294862252
Product thrombopoietin isoform 3 precursor
RefSeq Status REVIEWED
mRNA NM_001177597, 294862249
Protein NP_001171068, 294862250
Product thrombopoietin isoform 2 precursor
RefSeq Status REVIEWED
KEGG
hsa04640Hematopoietic cell lineage
Reactome
REACT_604Hemostasis
REACT_622Platelet activation triggers
REACT_20Formation of Platelet plug
REACT_798Platelet Activation
Homo sapiens (human)THPONP_000451.1
Pan troglodytes (chimpanzee)THPOXP_001136518.1
Canis lupus familiaris (dog)THPOXP_849268.1
Bos taurus (cattle)THPOXP_581912.3
Mus musculus (house mouse)ThpoNP_033405.1
Rattus norvegicus (Norway rat)ThpoNP_112395.1
Process
IDNameEvidence
GO:0007275multicellular organismal developmentTAS
GO:0007596blood coagulationTAS
GO:0008283cell proliferationTAS
GO:0008284positive regulation of cell proliferationIEA
GO:0030099myeloid cell differentiationIEA
GO:0030168platelet activationTAS
GO:0032496response to lipopolysaccharideIEA
Component
IDNameEvidence
GO:0005576extracellular regionIEA
GO:0005615extracellular spaceIEA
Function
IDNameEvidence
GO:0005125cytokine activityIEA
GO:0005179hormone activityIEA
GO:0008083growth factor activityTAS
GeneCards THPO
PDB 1V7M, 1V7N
UniProt Q5FBX8, P40225
MIM 600044
Ensembl ENSG00000090534
HGNC 11795
HPRD 02500

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.

Secured Online Quotation
Email: gene@genscript.com
Phone: 1-877-436-7274 (Toll-Free) 1-732-885-9188
Fax: 1-732-210-0262 1-732-885-5878