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Sequence in raw or FASTA format:

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THPO thrombopoietin [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_000460 Homo sapiens thrombopoietin (THPO), transcript variant 1, mRNA. ORF Sequence $307.98
Peptide Services
Antibody Services
Protein Services
NM_001177597 Homo sapiens thrombopoietin (THPO), transcript variant 2, mRNA. ORF Sequence $304.50
Peptide Services
Antibody Services
Protein Services
NM_001177598 Homo sapiens thrombopoietin (THPO), transcript variant 3, mRNA. ORF Sequence $278.40
Peptide Services
Antibody Services
Protein Services


Gene Symbol THPO
Entrez Gene ID 7066
Full Name thrombopoietin
Synonyms MGC163194, MGDF, MKCSF, ML, MPLLG, TPO
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

3

3q27

Summary Megakaryocytopoiesis is the cellular development process that leads to platelet production. The protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternate splicing results in multiple transcript variants of this gene.[provided by RefSeq, Jun 2012].
Disorder

MIM: 600044

Thrombocythemia, essential, 187950 (3)

mRNA Protein Product Sequence Price Select
NM_000460, 40805871 NP_000451, 4507493 thrombopoietin isoform 1 precursor Full Length $523.45
ORF Sequence $307.98
NM_001177597, 294862249 NP_001171068, 294862250 thrombopoietin isoform 2 precursor Full Length $519.97
ORF Sequence $304.50
NM_001177598, 294862251 NP_001171069, 294862252 thrombopoietin isoform 3 precursor Full Length $518.52
ORF Sequence $278.40
KEGG
hsa04640Hematopoietic cell lineage
Reactome
REACT_798Platelet activation, signaling and aggregation
REACT_278Platelet Aggregation (Plug Formation)
REACT_604Hemostasis
Homo sapiens (human)THPONP_001171068.1
Pan troglodytes (chimpanzee)THPOXP_001136518.2
Canis lupus familiaris (dog)LOC100855822XP_003640179.1
Bos taurus (cattle)THPONP_001159512.1
Mus musculus (house mouse)ThpoNP_033405.1
Rattus norvegicus (Norway rat)ThpoNP_112395.1
GeneCards THPO
PDB 1V7M, 1V7N
UniProt Q5FBX8, P40225
MIM 600044
Ensembl ENSG00000090534
HGNC 11795
HPRD 02500

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
thrombopoietin
Names
thrombopoietin
MPL ligand
c-mpl ligand
thrombopoietin nirs variant 1
megakaryocyte stimulating factor
megakaryocyte colony-stimulating factor
megakaryocyte growth and development factor
myeloproliferative leukemia virus oncogene ligand

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