ICAM5 intercellular adhesion molecule 5, telencephalin [Homo sapiens (human)]
| Gene Symbol | ICAM5 |
| Entrez Gene ID | 7087 |
| Full Name | intercellular adhesion molecule 5, telencephalin |
| Synonyms | TLCN, TLN |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
19 19p13.2 |
| Summary | The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases. [provided by RefSeq]. |
| Disorder | MIM: 601852 |
| mRNA | NM_003259, 189571582 |
| Protein | NP_003250, 189571583 |
| Product | intercellular adhesion molecule 5 precursor |
| RefSeq Status | REVIEWED |
| Homo sapiens (human) | ICAM5 | NP_003250.3 |
| Canis lupus familiaris (dog) | ICAM5 | XP_542074.2 |
| Bos taurus (cattle) | ICAM5 | XP_001790431.1 |
| Mus musculus (house mouse) | Icam5 | NP_032345.1 |
| Rattus norvegicus (Norway rat) | Icam5 | XP_233737.4 |
| ID | Name | Evidence |
| GO:0006909 | phagocytosis | IEA |
| GO:0016337 | cell-cell adhesion | IEA |
Component
| ID | Name | Evidence |
| GO:0005886 | plasma membrane | IEA |
| GO:0005887 | integral to plasma membrane | TAS |
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