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TLR1 toll-like receptor 1 [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_003263 Homo sapiens toll-like receptor 1 (TLR1), mRNA. ORF Sequence $684.69
Peptide Services
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Gene Symbol TLR1
Entrez Gene ID 7096
Full Name toll-like receptor 1
Synonyms CD281, DKFZp547I0610, DKFZp564I0682, KIAA0012, MGC104956, MGC126311, MGC126312, TIL, TIL. LPRS5, rsc786
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4p14

Summary The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene. [provided by RefSeq, Jul 2008].
Disorder

MIM: 601194

{Leprosy, protection against}, 613223 (3); {Leprosy, susceptibility

mRNA Protein Product Sequence Price Select
NM_003263, 41350336 NP_003254, 41350337 toll-like receptor 1 Full Length $831.43
ORF Sequence $684.69
KEGG
hsa04620Toll-like receptor signaling pathway
hsa05152Tuberculosis
WikiPathways
WP75Toll-like receptor signaling pathway
Reactome
REACT_6802Innate Immune System
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_6890Activated TLR4 signalling
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_6900Immune System
REACT_6966Toll Receptor Cascades
REACT_115846Defensins
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_115897Beta defensins
Homo sapiens (human)TLR1NP_003254.2
Pan troglodytes (chimpanzee)TLR1NP_001123937.1
Macaca mulatta (Rhesus monkey)TLR1NP_001123896.1
Canis lupus familiaris (dog)TLR1NP_001139615.1
Mus musculus (house mouse)Tlr1NP_109607.1
Rattus norvegicus (Norway rat)LOC100363038XP_002728155.1
GeneCards TLR1
PDB 1FYV, 2Z7X
UniProt Q15399, Q32MK4
MIM 601194
Ensembl ENSG00000174125
HGNC 11847
HPRD 03119

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
toll-like receptor 1
Names
toll-like receptor 1
toll/interleukin-1 receptor-like protein

Interactant

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