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TLR1 toll-like receptor 1 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu19306 NM_003263 Homo sapiens toll-like receptor 1 (TLR1), mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu19306 XM_005262662 PREDICTED: Homo sapiens toll-like receptor 1 (TLR1), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu19306 XM_005262663 PREDICTED: Homo sapiens toll-like receptor 1 (TLR1), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu19306 XM_006714028 PREDICTED: Homo sapiens toll-like receptor 1 (TLR1), transcript variant X6, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu19306 XM_005262665 PREDICTED: Homo sapiens toll-like receptor 1 (TLR1), transcript variant X4, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu19306 XM_005262666 PREDICTED: Homo sapiens toll-like receptor 1 (TLR1), transcript variant X5, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu19306C NM_003263 Homo sapiens toll-like receptor 1 (TLR1), mRNA. Customized vector In-stock 5-7 $149.00
OHu19306C XM_005262662 PREDICTED: Homo sapiens toll-like receptor 1 (TLR1), transcript variant X1, mRNA. Customized vector On-demand 12-14 $329.00
OHu19306C XM_005262663 PREDICTED: Homo sapiens toll-like receptor 1 (TLR1), transcript variant X2, mRNA. Customized vector On-demand 12-14 $329.00
OHu19306C XM_006714028 PREDICTED: Homo sapiens toll-like receptor 1 (TLR1), transcript variant X6, mRNA. Customized vector On-demand 12-14 $329.00
OHu19306C XM_005262665 PREDICTED: Homo sapiens toll-like receptor 1 (TLR1), transcript variant X4, mRNA. Customized vector On-demand 12-14 $329.00
OHu19306C XM_005262666 PREDICTED: Homo sapiens toll-like receptor 1 (TLR1), transcript variant X5, mRNA. Customized vector On-demand 12-14 $329.00

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Gene Symbol TLR1
Entrez Gene ID 7096
Full Name toll-like receptor 1
Synonyms CD281, TIL, TIL. LPRS5, rsc786
General protein information
Preferred Names
toll-like receptor 1
Names
toll-like receptor 1
toll/interleukin-1 receptor-like protein
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4p14

Summary The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene. [provided by RefSeq, Jul 2008].
Disorder

MIM: 601194

{Leprosy, protection against}, 613223 (3); {Leprosy, susceptibility

mRNA Protein Product Sequence Price Select
NM_003263, 41350336 NP_003254, 41350337 toll-like receptor 1 precursor ORF Sequence $660.00
XM_005262662, 578808583 XP_005262719, 530376505 toll-like receptor 1 isoform X1 ORF Sequence $750.00
XM_005262663, 578808584 XP_005262720, 530376507 toll-like receptor 1 isoform X2 ORF Sequence $750.00
XM_005262665, 578808587 XP_005262722, 530376511 toll-like receptor 1 isoform X4 ORF Sequence $750.00
XM_005262666, 578808588 XP_005262723, 530376513 toll-like receptor 1 isoform X5 ORF Sequence $750.00
XM_006714028, 578808585 XP_006714091, 578808586 toll-like receptor 1 isoform X6 ORF Sequence $750.00
KEGG
hsa04620Toll-like receptor signaling pathway
hsa05152Tuberculosis
WikiPathways
WP75Toll-like receptor signaling pathway
WP1449Regulation of toll-like receptor signaling pathway
Reactome
REACT_6802Innate Immune System
REACT_6900Immune System
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_6890Activated TLR4 signalling
REACT_6966Toll-Like Receptors Cascades
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_115846Defensins
REACT_115897Beta defensins
Homo sapiens (human)TLR1NP_003254.2
Pan troglodytes (chimpanzee)TLR1NP_001123937.1
Macaca mulatta (Rhesus monkey)TLR1NP_001123896.1
Canis lupus familiaris (dog)TLR1NP_001139615.1
Mus musculus (house mouse)Tlr1NP_001263374.1
Rattus norvegicus (Norway rat)Tlr1NP_001165591.1
Danio rerio (zebrafish)tlr1NP_001124065.1
Xenopus (Silurana) tropicalis (western clawed frog)tlr1XP_002938702.2
Xenopus (Silurana) tropicalis (western clawed frog)LOC100495326XP_002938703.2
Process
IDNameEvidence
GO:0002755MyD88-dependent toll-like receptor signaling pathwayIEA
GO:0006954inflammatory responseIEA
GO:0006955immune responseTAS
GO:0007165signal transductionTAS
GO:0034130toll-like receptor 1 signaling pathwayIEA
GO:0042116macrophage activationNAS
GO:0042495detection of triacyl bacterial lipopeptideIDA
GO:0042535positive regulation of tumor necrosis factor biosynthetic processISS
GO:0045087innate immune responseIEA
GO:0045410positive regulation of interleukin-6 biosynthetic processISS
GO:0050707regulation of cytokine secretionIEA
GO:0071727cellular response to triacyl bacterial lipopeptideIDA
Component
IDNameEvidence
GO:0005886plasma membraneTAS
GO:0005887integral component of plasma membraneTAS
GO:0016020membraneNAS
GO:0030670phagocytic vesicle membraneIEA
GO:0035354Toll-like receptor 1-Toll-like receptor 2 protein complexIDA
Function
IDNameEvidence
GO:0004872receptor activityTAS
GO:0004888transmembrane signaling receptor activityNAS
GO:0046982protein heterodimerization activityIDA
GeneCards TLR1
PDB 1FYV, 2Z7X
UniProt Q15399
Vega OTTHUMG00000160413
MIM 601194
Ensembl ENSG00000174125
HGNC 11847
HPRD 03119

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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