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TNF tumor necrosis factor [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000594 Homo sapiens tumor necrosis factor (TNF), mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 10

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Gene Symbol TNF
Entrez Gene ID 7124
Full Name tumor necrosis factor
Synonyms DIF, TNF-alpha, TNFA, TNFSF2
General protein information
Preferred Names
tumor necrosis factor
Names
tumor necrosis factor
TNF-a
cachectin
APC1 protein
TNF, monocyte-derived
TNF, macrophage-derived
tumor necrosis factor-alpha
tumor necrosis factor ligand superfamily member 2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6p21.3

Summary This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008].
Disorder

MIM: 191160

{Malaria, cerebral, susceptibility to}, 611162 (3); {Septic shock,

mRNA Protein Product Sequence Price Select
NM_000594, 395132451 NP_000585, 25952111 tumor necrosis factor ORF Sequence $159.00
KEGG
hsa04010MAPK signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04060Cytokine-cytokine receptor interaction
hsa04210Apoptosis
hsa04664Fc epsilon RI signaling pathway
hsa04150mTOR signaling pathway
hsa04612Antigen processing and presentation
hsa04350TGF-beta signaling pathway
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa04640Hematopoietic cell lineage
hsa04930Type II diabetes mellitus
hsa04660T cell receptor signaling pathway
hsa05332Graft-versus-host disease
hsa04620Toll-like receptor signaling pathway
hsa04920Adipocytokine signaling pathway
hsa05310Asthma
hsa05322Systemic lupus erythematosus
hsa04940Type I diabetes mellitus
hsa05010Alzheimer's disease
hsa05330Allograft rejection
hsa04622RIG-I-like receptor signaling pathway
hsa05414Dilated cardiomyopathy
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa04621NOD-like receptor signaling pathway
hsa05142Chagas disease (American trypanosomiasis)
hsa05140Leishmaniasis
hsa05145Toxoplasmosis
hsa05144Malaria
hsa05146Amoebiasis
hsa05160Hepatitis C
hsa05143African trypanosomiasis
hsa05323Rheumatoid arthritis
hsa05166HTLV-I infection
hsa04380Osteoclast differentiation
hsa05152Tuberculosis
hsa05164Influenza A
hsa05168Herpes simplex infection
hsa05133Pertussis
hsa05134Legionellosis
hsa05161Hepatitis B
hsa05205Proteoglycans in cancer
hsa04064NF-kappa B signaling pathway
hsa05321Inflammatory bowel disease (IBD)
hsa04668TNF signaling pathway
hsa04932Non-alcoholic fatty liver disease (NAFLD)
WikiPathways
WP382MAPK signaling pathway
WP254Apoptosis
WP1544MicroRNAs in cardiomyocyte hypertrophy
WP1584Type II diabetes mellitus
WP560TGF Beta Signaling Pathway
WP262EBV LMP1 signaling
WP530Cytokines and Inflammatory Response
WP15Selenium Pathway
WP236Adipogenesis
WP727Monoamine Transport
WP268Notch Signaling Pathway
WP129Matrix Metalloproteinases
WP75Toll-like receptor signaling pathway
WP314FAS pathway and Stress induction of HSP regulation
WP231TNF-alpha/NF-kB Signaling Pathway
WP706SIDS Susceptibility Pathways
WP2377Integrated Pancreatic Cancer Pathway
WP2036TWEAK Signaling Pathway
WP2059Alzheimers Disease
WP2431Spinal Cord Injury
WP2100AhR pathway
WP1449Regulation of toll-like receptor signaling pathway
WP2328Allograft Rejection
WP2447Amyotrophic lateral sclerosis (ALS)
Pathway Interaction Database
il27pathwayIL27-mediated signaling events
angiopoietinreceptor_pathwayAngiopoietin receptor Tie2-mediated signaling
hivnefpathwayHIV-1 Nef: Negative effector of Fas and TNF-alpha
hdac_classi_pathwaySignaling events mediated by HDAC Class I
caspase_pathwayCaspase cascade in apoptosis
nfat_tfpathwayCalcineurin-regulated NFAT-dependent transcription in lymphocytes
amb2_neutrophils_pathwayamb2 Integrin signaling
rxr_vdr_pathwayRXR and RAR heterodimerization with other nuclear receptor
il23pathwayIL23-mediated signaling events
cd8tcrdownstreampathwayDownstream signaling in naive CD8+ T cells
ceramide_pathwayCeramide signaling pathway
nfkappabcanonicalpathwayCanonical NF-kappaB pathway
anthraxpathwayCellular roles of Anthrax toxin
tnfpathwayTNF receptor signaling pathway
Reactome
REACT_578Apoptosis
REACT_1059Extrinsic Pathway for Apoptosis
REACT_1619Death Receptor Signalling
REACT_1432TNF signaling
REACT_27161Transcriptional regulation of white adipocyte differentiation
REACT_111045Developmental Biology
Homo sapiens (human)TNFNP_000585.2
Pan troglodytes (chimpanzee)TNFNP_001038976.1
Macaca mulatta (Rhesus monkey)TNFNP_001040614.1
Canis lupus familiaris (dog)TNFNP_001003244.4
Bos taurus (cattle)TNFNP_776391.2
Mus musculus (house mouse)TnfNP_038721.1
Rattus norvegicus (Norway rat)TnfNP_036807.1
Xenopus (Silurana) tropicalis (western clawed frog)tnfNP_001107143.1
Process
IDNameEvidence
GO:0000060protein import into nucleus, translocationIDA
GO:0000122negative regulation of transcription from RNA polymerase II promoterIDA
GO:0000165MAPK cascadeIMP
GO:0000185activation of MAPKKK activityIDA
GO:0000187activation of MAPK activityIDA
GO:0001666response to hypoxiaIEA
GO:0001775cell activationIEA
GO:0001819positive regulation of cytokine productionIDA
GO:0001934positive regulation of protein phosphorylationIDA
GO:0002037negative regulation of L-glutamate transportIEA
GO:0002439chronic inflammatory response to antigenic stimulusIMP
GO:0002740negative regulation of cytokine secretion involved in immune responseIDA
GO:0002876positive regulation of chronic inflammatory response to antigenic stimulusIEA
GO:0002925positive regulation of humoral immune response mediated by circulating immunoglobulinIEA
GO:0003009skeletal muscle contractionIEA
GO:0006006glucose metabolic processIEA
GO:0006915apoptotic processTAS
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic processIDA
GO:0006927transformed cell apoptotic processIDA
GO:0006954inflammatory responseIDA
GO:0006959humoral immune responseIEA
GO:0007254JNK cascadeIEA
GO:0008285negative regulation of cell proliferationIEA
GO:0008625extrinsic apoptotic signaling pathway via death domain receptorsIDA
GO:0008625extrinsic apoptotic signaling pathway via death domain receptorsNAS
GO:0008630intrinsic apoptotic signaling pathway in response to DNA damageIEA
GO:0008652cellular amino acid biosynthetic processIEA
GO:0009612response to mechanical stimulusIEA
GO:0009615response to virusIDA
GO:0009651response to salt stressTAS
GO:0009887organ morphogenesisIEA
GO:0010628positive regulation of gene expressionIDA
GO:0010629negative regulation of gene expressionIDA
GO:0010693negative regulation of alkaline phosphatase activityIEA
GO:0010888negative regulation of lipid storageNAS
GO:0014823response to activityIEA
GO:0019722calcium-mediated signalingIEA
GO:0030198extracellular matrix organizationIEA
GO:0030316osteoclast differentiationIEA
GO:0030730sequestering of triglycerideIDA
GO:0031334positive regulation of protein complex assemblyIDA
GO:0031622positive regulation of fever generationISS
GO:0031663lipopolysaccharide-mediated signaling pathwayIDA
GO:0032715negative regulation of interleukin-6 productionIDA
GO:0032722positive regulation of chemokine productionIDA
GO:0032729positive regulation of interferon-gamma productionIEA
GO:0032741positive regulation of interleukin-18 productionIEA
GO:0032755positive regulation of interleukin-6 productionIEA
GO:0032800receptor biosynthetic processIDA
GO:0033138positive regulation of peptidyl-serine phosphorylationIDA
GO:0033209tumor necrosis factor-mediated signaling pathwayIMP
GO:0034116positive regulation of heterotypic cell-cell adhesionIDA
GO:0042346positive regulation of NF-kappaB import into nucleusIDA
GO:0042493response to drugIEA
GO:0043065positive regulation of apoptotic processIDA
GO:0043068positive regulation of programmed cell deathIDA
GO:0043122regulation of I-kappaB kinase/NF-kappaB signalingIDA
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signalingIDA
GO:0043242negative regulation of protein complex disassemblyIDA
GO:0043243positive regulation of protein complex disassemblyIDA
GO:0043280positive regulation of cysteine-type endopeptidase activity involved in apoptotic processIDA
GO:0043406positive regulation of MAP kinase activityIDA
GO:0043491protein kinase B signalingIMP
GO:0043507positive regulation of JUN kinase activityIDA
GO:0043525positive regulation of neuron apoptotic processIEA
GO:0044130negative regulation of growth of symbiont in hostIEA
GO:0045071negative regulation of viral genome replicationIDA
GO:0045080positive regulation of chemokine biosynthetic processIDA
GO:0045416positive regulation of interleukin-8 biosynthetic processIDA
GO:0045429positive regulation of nitric oxide biosynthetic processIDA
GO:0045599negative regulation of fat cell differentiationNAS
GO:0045668negative regulation of osteoblast differentiationIEA
GO:0045672positive regulation of osteoclast differentiationIDA
GO:0045840positive regulation of mitosisIEA
GO:0045892negative regulation of transcription, DNA-templatedIDA
GO:0045893positive regulation of transcription, DNA-templatedIDA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIGI
GO:0045994positive regulation of translational initiation by ironIEA
GO:0046325negative regulation of glucose importIEA
GO:0046330positive regulation of JNK cascadeIEA
GO:0048566embryonic digestive tract developmentIEP
GO:0048661positive regulation of smooth muscle cell proliferationIDA
GO:0050715positive regulation of cytokine secretionIDA
GO:0050796regulation of insulin secretionIDA
GO:0050806positive regulation of synaptic transmissionIEA
GO:0050830defense response to Gram-positive bacteriumIEA
GO:0050901leukocyte tethering or rollingIDA
GO:0050995negative regulation of lipid catabolic processIDA
GO:0051023regulation of immunoglobulin secretionIEA
GO:0051044positive regulation of membrane protein ectodomain proteolysisIDA
GO:0051091positive regulation of sequence-specific DNA binding transcription factor activityIDA
GO:0051092positive regulation of NF-kappaB transcription factor activityIDA
GO:0051222positive regulation of protein transportIDA
GO:0051384response to glucocorticoidIDA
GO:0051533positive regulation of NFAT protein import into nucleusIDA
GO:0051798positive regulation of hair follicle developmentIEA
GO:0051897positive regulation of protein kinase B signalingIEA
GO:0060557positive regulation of vitamin D biosynthetic processIDA
GO:0060559positive regulation of calcidiol 1-monooxygenase activityIDA
GO:0060664epithelial cell proliferation involved in salivary gland morphogenesisIEA
GO:0060693regulation of branching involved in salivary gland morphogenesisIEA
GO:0061048negative regulation of branching involved in lung morphogenesisIDA
GO:0070374positive regulation of ERK1 and ERK2 cascadeNAS
GO:0071230cellular response to amino acid stimulusIEA
GO:0071316cellular response to nicotineIDA
GO:0071407cellular response to organic cyclic compoundIDA
GO:0071677positive regulation of mononuclear cell migrationNAS
GO:0071803positive regulation of podosome assemblyIDA
GO:0097190apoptotic signaling pathwayTAS
GO:0097191extrinsic apoptotic signaling pathwayIDA
GO:0097527necroptotic signaling pathwayIDA
GO:1902043positive regulation of extrinsic apoptotic signaling pathway via death domain receptorsIEA
GO:2000010positive regulation of protein localization to cell surfaceIDA
GO:2000343positive regulation of chemokine (C-X-C motif) ligand 2 productionIDA
GO:2001240negative regulation of extrinsic apoptotic signaling pathway in absence of ligandIDA
Component
IDNameEvidence
GO:0001891phagocytic cupISS
GO:0005576extracellular regionTAS
GO:0005615extracellular spaceIDA
GO:0005886plasma membraneTAS
GO:0005887integral component of plasma membraneIDA
GO:0009897external side of plasma membraneISS
GO:0009986cell surfaceIDA
GO:0045121membrane raftIDA
GO:0055037recycling endosomeISS
Function
IDNameEvidence
GO:0002020protease bindingIPI
GO:0005125cytokine activityIDA
GO:0005164tumor necrosis factor receptor bindingIDA
GO:0005515protein bindingIPI
GO:0042802identical protein bindingIDA
GO:0044212transcription regulatory region DNA bindingIDA
GeneCards TNF
PDB 2ZJC, 2TUN, 2ZPX, 2E7A, 3WD5, 3IT8, 3ALQ, 2AZ5, 1TNF, 4TSV, 5TSW, 3L9J, 4G3Y, 1A8M
UniProt Q5STB3, P01375
Vega OTTHUMG00000031194
MIM 191160
Ensembl ENSG00000232810
HGNC 11892
HPRD 01855

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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