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TNF tumor necrosis factor [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000594 Homo sapiens tumor necrosis factor (TNF), mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 10

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Gene Symbol TNF
Entrez Gene ID 7124
Full Name tumor necrosis factor
Synonyms DIF, TNF-alpha, TNFA, TNFSF2
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008].

MIM: 191160

{Malaria, cerebral, susceptibility to}, 611162 (3); {Septic shock,

mRNA Protein Product Sequence Price Select
NM_000594, 395132451 NP_000585, 25952111 tumor necrosis factor ORF Sequence $159.00
hsa05160Hepatitis C
hsa05164Influenza A
hsa05322Systemic lupus erythematosus
hsa04664Fc epsilon RI signaling pathway
hsa04064NF-kappa B signaling pathway
hsa05168Herpes simplex infection
hsa04622RIG-I-like receptor signaling pathway
hsa04621NOD-like receptor signaling pathway
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05142Chagas disease (American trypanosomiasis)
hsa04010MAPK signaling pathway
hsa04612Antigen processing and presentation
hsa05010Alzheimer's disease
hsa05332Graft-versus-host disease
hsa05414Dilated cardiomyopathy
hsa04350TGF-beta signaling pathway
hsa04380Osteoclast differentiation
hsa04150mTOR signaling pathway
hsa05330Allograft rejection
hsa05161Hepatitis B
hsa04920Adipocytokine signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa04940Type I diabetes mellitus
hsa04930Type II diabetes mellitus
hsa05143African trypanosomiasis
hsa04660T cell receptor signaling pathway
hsa04060Cytokine-cytokine receptor interaction
hsa05166HTLV-I infection
hsa04640Hematopoietic cell lineage
hsa05323Rheumatoid arthritis
hsa04620Toll-like receptor signaling pathway
Pathway Interaction Database
il27pathwayIL27-mediated signaling events
hivnefpathwayHIV-1 Nef: Negative effector of Fas and TNF-alpha
ceramide_pathwayCeramide signaling pathway
cd8tcrdownstreampathwayDownstream signaling in naive CD8+ T cells
il23pathwayIL23-mediated signaling events
angiopoietinreceptor_pathwayAngiopoietin receptor Tie2-mediated signaling
anthraxpathwayCellular roles of Anthrax toxin
caspase_pathwayCaspase cascade in apoptosis
nfat_tfpathwayCalcineurin-regulated NFAT-dependent transcription in lymphocytes
amb2_neutrophils_pathwayamb2 Integrin signaling
rxr_vdr_pathwayRXR and RAR heterodimerization with other nuclear receptor
hdac_classi_pathwaySignaling events mediated by HDAC Class I
nfkappabcanonicalpathwayCanonical NF-kappaB pathway
tnfpathwayTNF receptor signaling pathway
WP231TNF-alpha/NF-kB Signaling Pathway
WP1544MicroRNAs in cardiomyocyte hypertrophy
WP268Notch Signaling Pathway
WP129Matrix Metalloproteinases
WP2059Alzheimers Disease
WP1584Type II diabetes mellitus
WP2036TWEAK Signaling Pathway
WP2377Integrated Pancreatic Cancer Pathway
WP2256Integrated Pancreatic Cancer Pathway
WP727Monoamine Transport
WP15Selenium Pathway
WP262EBV LMP1 signaling
WP382MAPK signaling pathway
WP706SIDS Susceptibility Pathways
WP530Cytokines and Inflammatory Response
WP75Toll-like receptor signaling pathway
WP560TGF Beta Signaling Pathway
WP314FAS pathway and Stress induction of HSP regulation
REACT_1619Death Receptor Signalling
REACT_1432TNF signaling
REACT_111045Developmental Biology
REACT_27161Transcriptional Regulation of White Adipocyte Differentiation
REACT_1059Extrinsic Pathway for Apoptosis
Homo sapiens (human)TNFNP_000585.2
Pan troglodytes (chimpanzee)TNFNP_001038976.1
Macaca mulatta (Rhesus monkey)TNFNP_001040614.1
Canis lupus familiaris (dog)TNFNP_001003244.4
Bos taurus (cattle)TNFNP_776391.2
Mus musculus (house mouse)TnfNP_038721.1
Rattus norvegicus (Norway rat)TnfNP_036807.1
GeneCards TNF
PDB 2ZJC, 2TUN, 2ZPX, 2E7A, 3IT8, 3ALQ, 2AZ5, 1TNF, 4TSV, 5TSW, 3L9J, 1A8M
UniProt Q5STB3, P01375
MIM 191160
Ensembl ENSG00000232810
HGNC 11892
HPRD 01855

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
tumor necrosis factor
tumor necrosis factor
APC1 protein
TNF, monocyte-derived
TNF, macrophage-derived
tumor necrosis factor-alpha
tumor necrosis factor ligand superfamily member 2


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