TNFRSF1B tumor necrosis factor receptor superfamily, member 1B [Homo sapiens (human)]
| Gene Symbol | TNFRSF1B |
| Entrez Gene ID | 7133 |
| Full Name | tumor necrosis factor receptor superfamily, member 1B |
| Synonyms | CD120b, TBPII, TNF-R-II, TNF-R75, TNFBR, TNFR1B, TNFR2, TNFR80, p75, p75TNFR |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
1 1p36.22 |
| Summary | The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq]. |
| Disorder | MIM: 191191 |
| mRNA | NM_001066, 23312365 |
| Protein | NP_001057, 4507577 |
| Product | tumor necrosis factor receptor superfamily member 1B precursor |
| RefSeq Status | REVIEWED |
| hsa04920 | Adipocytokine signaling pathway |
| hsa05014 | Amyotrophic lateral sclerosis (ALS) |
| hsa04060 | Cytokine-cytokine receptor interaction |
Pathway Interaction Database
| tnfpathway | TNF receptor signaling pathway |
WikiPathways
| WP286 | IL-3 Signaling Pathway |
| WP254 | Apoptosis |
| WP231 | TNF-alpha/NF-kB Signaling Pathway |
| WP453 | Inflammatory Response Pathway |
| Homo sapiens (human) | TNFRSF1B | NP_001057.1 |
| Pan troglodytes (chimpanzee) | TNFRSF1B | XP_514405.2 |
| Canis lupus familiaris (dog) | TNFRSF1B | XP_544562.2 |
| Bos taurus (cattle) | TNFRSF1B | NP_001035580.1 |
| Mus musculus (house mouse) | Tnfrsf1b | NP_035740.2 |
| Rattus norvegicus (Norway rat) | Tnfrsf1b | NP_569110.1 |
| Gallus gallus (chicken) | TNFRSF1B | NP_989770.2 |
| Danio rerio (zebrafish) | zgc:163064 | NP_001082979.1 |
| ID | Name | Evidence |
| GO:0006915 | apoptosis | IEA |
| GO:0006955 | immune response | IEA |
| GO:0007166 | cell surface receptor linked signaling pathway | IEA |
| GO:0008219 | cell death | IEA |
| GO:0033209 | tumor necrosis factor-mediated signaling pathway | TAS |
| GO:0050728 | negative regulation of inflammatory response | IEA |
| GO:0050779 | RNA destabilization | IEA |
Component
| ID | Name | Evidence |
| GO:0005576 | extracellular region | IEA |
| GO:0005624 | membrane fraction | IEA |
| GO:0005886 | plasma membrane | IEA |
| GO:0016021 | integral to membrane | IEA |
| GO:0045121 | membrane raft | IDA |
Function
| ID | Name | Evidence |
| GO:0004872 | receptor activity | IEA |
| GO:0005031 | tumor necrosis factor receptor activity | IEA |
| GO:0005515 | protein binding | IPI |
Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.
 |
Secured Online Quotation |
 |
Email: gene@genscript.com |
 |
Phone: 1-877-436-7274 (Toll-Free) 1-732-885-9188 |
 |
Fax: 1-732-210-0262 1-732-885-5878 |