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TNFRSF1B tumor necrosis factor receptor superfamily, member 1B [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_001066 Homo sapiens tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B), mRNA. ORF Sequence $401.94
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Gene Symbol TNFRSF1B
Entrez Gene ID 7133
Full Name tumor necrosis factor receptor superfamily, member 1B
Synonyms CD120b, TBPII, TNF-R-II, TNF-R75, TNFBR, TNFR1B, TNFR2, TNFR80, p75, p75TNFR
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1p36.22

Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008].
Disorder

MIM: 191191

mRNA Protein Product Sequence Price Select
NM_001066, 23312365 NP_001057, 4507577 tumor necrosis factor receptor superfamily member 1B precursor Full Length $1288.70
ORF Sequence $401.94
KEGG
hsa04060Cytokine-cytokine receptor interaction
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa04920Adipocytokine signaling pathway
Pathway Interaction Database
tnfpathwayTNF receptor signaling pathway
WikiPathways
WP1772Apoptosis Modulation and Signaling
WP286IL-3 Signaling Pathway
WP254Apoptosis
WP231TNF-alpha/NF-kB Signaling Pathway
WP453Inflammatory Response Pathway
Homo sapiens (human)TNFRSF1BNP_001057.1
Pan troglodytes (chimpanzee)TNFRSF1BXP_514405.4
Macaca mulatta (Rhesus monkey)TNFRSF1BXP_001105753.1
Canis lupus familiaris (dog)TNFRSF1BXP_544562.3
Bos taurus (cattle)TNFRSF1BNP_001035580.1
Mus musculus (house mouse)Tnfrsf1bNP_035740.2
Rattus norvegicus (Norway rat)Tnfrsf1bNP_569110.1
Gallus gallus (chicken)TNFRSF1BNP_989770.2
Danio rerio (zebrafish)zgc:163064NP_001082979.1
GeneCards TNFRSF1B
PDB 1CA9, 3ALQ
UniProt P20333
MIM 191191
Ensembl ENSG00000028137
HGNC 11917
HPRD 01862

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
tumor necrosis factor receptor superfamily member 1B
Names
tumor necrosis factor receptor superfamily member 1B
TNF-R2
TNF-RII
p75 TNF receptor
p80 TNF-alpha receptor
soluble TNFR1B variant 1
tumor necrosis factor receptor 2
tumor necrosis factor beta receptor
tumor necrosis factor receptor type II
tumor necrosis factor binding protein 2

Interactant

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