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TNNI3 troponin I type 3 (cardiac) [Homo sapiens (human)]

Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu25717D NM_000363 Homo sapiens troponin I type 3 (cardiac) (TNNI3), mRNA. pcDNA3.1-C-(k)DYK In-stock 5-7 Starting from $99
OHu25717C NM_000363 Homo sapiens troponin I type 3 (cardiac) (TNNI3), mRNA. Customized vector In-stock 5-7 Starting from $99

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Gene Symbol TNNI3
Entrez Gene ID 7137
Full Name troponin I type 3 (cardiac)
Synonyms CMD1FF, CMD2A, CMH7, RCM1, TNNC1, cTnI
General protein information
Preferred Names
troponin I, cardiac muscle
troponin I, cardiac muscle
Gene Type protein-coding
Organism Homo sapiens (human)



Summary Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq, Jul 2008].

MIM: 191044

Cardiomyopathy, familial hypertrophic, 7, 613690 (3); Cardiomyopathy,

mRNA Protein Product Sequence Price Select
NM_000363, 151101269 NP_000354, 151101270 troponin I, cardiac muscle ORF Sequence $159.00
hsa04260Cardiac muscle contraction
hsa05414Dilated cardiomyopathy
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa04261Adrenergic signaling in cardiomyocytes
WP383Striated Muscle Contraction
WP2406Cardiac Progenitor Differentiation
REACT_16969Striated Muscle Contraction
REACT_17044Muscle contraction
Homo sapiens (human)TNNI3NP_000354.4
Pan troglodytes (chimpanzee)TNNI3XP_001134934.2
Macaca mulatta (Rhesus monkey)TNNI3XP_001085820.1
Canis lupus familiaris (dog)TNNI3NP_001003041.1
Bos taurus (cattle)LOC511094NP_001035607.1
Mus musculus (house mouse)Tnni3NP_033432.1
Rattus norvegicus (Norway rat)Tnni3NP_058840.1
Xenopus (Silurana) tropicalis (western clawed frog)tnni3NP_001011410.1
GO:0001980regulation of systemic arterial blood pressure by ischemic conditionsISS
GO:0006874cellular calcium ion homeostasisISS
GO:0006940regulation of smooth muscle contractionIEA
GO:0007507heart developmentISS
GO:0030049muscle filament slidingTAS
GO:0032780negative regulation of ATPase activityIDA
GO:0032780negative regulation of ATPase activityIMP
GO:0055010ventricular cardiac muscle tissue morphogenesisIMP
GO:0060047heart contractionIMP
GO:0060048cardiac muscle contractionIMP
GO:0005861troponin complexIDA
GO:0003779actin bindingIDA
GO:0005515protein bindingIPI
GO:0019855calcium channel inhibitor activityIPI
GO:0019901protein kinase bindingIPI
GO:0019904protein domain specific bindingIPI
GO:0030172troponin C bindingIPI
GO:0031014troponin T bindingIPI
GO:0046872metal ion bindingIEA
GO:0048306calcium-dependent protein bindingIPI
GeneCards TNNI3
PDB 1LXF, 2L1R, 2KRD, 2KGB, 1J1E, 1MXL, 1J1D, 1OZS
UniProt Q6FGX2, P19429
Vega OTTHUMG00000180589
MIM 191044
Ensembl ENSG00000129991
HGNC 11947
HPRD 11769

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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