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TNNT2 troponin T type 2 (cardiac) [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_000364 Homo sapiens troponin T type 2 (cardiac) (TNNT2), transcript variant 1, mRNA. ORF Sequence $257.52
Peptide Services
Antibody Services
Protein Services
NM_001001430 Homo sapiens troponin T type 2 (cardiac) (TNNT2), transcript variant 2, mRNA. ORF Sequence $251.43
Peptide Services
Antibody Services
Protein Services
NM_001001431 Homo sapiens troponin T type 2 (cardiac) (TNNT2), transcript variant 3, mRNA. ORF Sequence $248.82
Peptide Services
Antibody Services
Protein Services
NM_001001432 Homo sapiens troponin T type 2 (cardiac) (TNNT2), transcript variant 4, mRNA. ORF Sequence $246.21
Peptide Services
Antibody Services
Protein Services
NM_001276345 Homo sapiens troponin T type 2 (cardiac) (TNNT2), transcript variant 5, mRNA. ORF Sequence $260.13
Peptide Services
Antibody Services
Protein Services
NM_001276346 Homo sapiens troponin T type 2 (cardiac) (TNNT2), transcript variant 6, mRNA. ORF Sequence $222.72
Peptide Services
Antibody Services
Protein Services
NM_001276347 Homo sapiens troponin T type 2 (cardiac) (TNNT2), transcript variant 7, mRNA. ORF Sequence $251.43
Peptide Services
Antibody Services
Protein Services


Gene Symbol TNNT2
Entrez Gene ID 7139
Full Name troponin T type 2 (cardiac)
Synonyms CMH2, CMPD2, LVNC6, MGC3889, RCM3, TnTC, cTnT
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1q32

Summary The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. [provided by RefSeq, Jul 2008].
Disorder

MIM: 191045

Cardiomyopathy, familial hypertrophic, 2, 115195 (3); Cardiomyopathy,

mRNA Protein Product Sequence Price Select
NM_000364, 446714949 NP_000355, 48255877 troponin T, cardiac muscle isoform 1 Full Length $346.55
ORF Sequence $257.52
NM_001001430, 446714948 NP_001001430, 48255879 troponin T, cardiac muscle isoform 2 Full Length $340.46
ORF Sequence $251.43
NM_001001431, 446715104 NP_001001431, 48255881 troponin T, cardiac muscle isoform 3 Full Length $337.85
ORF Sequence $248.82
NM_001001432, 446715106 NP_001001432, 48255883 troponin T, cardiac muscle isoform 4 Full Length $335.24
ORF Sequence $246.21
NM_001276345, 446715146 NP_001263274, 446715147 troponin T, cardiac muscle isoform 5 Full Length $349.16
ORF Sequence $260.13
NM_001276346, 446715552 NP_001263275, 446715553 troponin T, cardiac muscle isoform 6 Full Length $311.75
ORF Sequence $222.72
NM_001276347, 446715781 NP_001263276, 446715782 troponin T, cardiac muscle isoform 2 Full Length $379.03
ORF Sequence $251.43
KEGG
hsa05414Dilated cardiomyopathy
hsa04260Cardiac muscle contraction
hsa05410Hypertrophic cardiomyopathy (HCM)
WikiPathways
WP383Striated Muscle Contraction
Reactome
REACT_17044Muscle contraction
REACT_16969Striated Muscle Contraction
Homo sapiens (human)TNNT2NP_000355.2
Pan troglodytes (chimpanzee)TNNT2XP_001145686.1
Macaca mulatta (Rhesus monkey)TNNT2XP_002802029.1
Canis lupus familiaris (dog)TNNT2NP_001003012.1
Bos taurus (cattle)TNNT2NP_777196.1
Mus musculus (house mouse)Tnnt2NP_001123648.1
Rattus norvegicus (Norway rat)Tnnt2NP_036808.1
Gallus gallus (chicken)TNNT2NP_990780.1
Danio rerio (zebrafish)tnnt2aNP_690853.1
GeneCards TNNT2
PDB 1J1E, 1J1D
UniProt P45379
MIM 191045
Ensembl ENSG00000118194
HGNC 11949
HPRD 01844

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
troponin T, cardiac muscle
Names
troponin T, cardiac muscle
troponin T2, cardiac
cardiomyopathy, hypertrophic 2
cardiomyopathy, dilated 1D (autosomal dominant)

Interactant

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