• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


TP53 tumor protein p53 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000546 Homo sapiens tumor protein p53 (TP53), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10
NM_001126112 Homo sapiens tumor protein p53 (TP53), transcript variant 2, mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10
NM_001126113 Homo sapiens tumor protein p53 (TP53), transcript variant 4, mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10
NM_001126114 Homo sapiens tumor protein p53 (TP53), transcript variant 3, mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10
NM_001126115 Homo sapiens tumor protein p53 (TP53), transcript variant 5, mRNA. GenEZ ORF Cloning In-stock $348.00 $299.00 10
NM_001126116 Homo sapiens tumor protein p53 (TP53), transcript variant 6, mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 10
NM_001126117 Homo sapiens tumor protein p53 (TP53), transcript variant 7, mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 10
NM_001126118 Homo sapiens tumor protein p53 (TP53), transcript variant 8, mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10
NM_001276695 Homo sapiens tumor protein p53 (TP53), transcript variant 4, mRNA. GenEZ ORF Cloning In-stock $348.00 $299.00 10
NM_001276696 Homo sapiens tumor protein p53 (TP53), transcript variant 3, mRNA. GenEZ ORF Cloning In-stock $348.00 $299.00 10
NM_001276697 Homo sapiens tumor protein p53 (TP53), transcript variant 5, mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 10
NM_001276698 Homo sapiens tumor protein p53 (TP53), transcript variant 6, mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 10
NM_001276699 Homo sapiens tumor protein p53 (TP53), transcript variant 7, mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 10
NM_001276760 Homo sapiens tumor protein p53 (TP53), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10
NM_001276761 Homo sapiens tumor protein p53 (TP53), transcript variant 2, mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10

*Business Day

Related Services

Gene Symbol TP53
Entrez Gene ID 7157
Full Name tumor protein p53
Synonyms BCC7, LFS1, P53, TRP53
General protein information
Preferred Names
cellular tumor antigen p53
Names
cellular tumor antigen p53
antigen NY-CO-13
phosphoprotein p53
p53 tumor suppressor
transformation-related protein 53
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17p13.1

Summary This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013].
Disorder

MIM: 191170

Colorectal cancer, 114500 (3); Li-Fraumeni syndrome, 151623 (3);

mRNA Protein Product Sequence Price Select
NM_000546, 371502114 NP_000537, 120407068 cellular tumor antigen p53 isoform a ORF Sequence $269.00
NM_001126112, 371502115 NP_001119584, 187830777 cellular tumor antigen p53 isoform a ORF Sequence $269.00
NM_001126113, 371502116 NP_001119585, 187830823 cellular tumor antigen p53 isoform c ORF Sequence $269.00
NM_001126114, 371502117 NP_001119586, 187830855 cellular tumor antigen p53 isoform b ORF Sequence $269.00
NM_001126115, 187830893 NP_001119587, 187830894 cellular tumor antigen p53 isoform d ORF Sequence $199.00
NM_001126116, 187830900 NP_001119588, 187830901 cellular tumor antigen p53 isoform e ORF Sequence $159.00
NM_001126117, 187830908 NP_001119589, 187830909 cellular tumor antigen p53 isoform f ORF Sequence $159.00
NM_001126118, 371502118 NP_001119590, 371502119 cellular tumor antigen p53 isoform g ORF Sequence $269.00
NM_001276695, 454543596 NP_001263624, 454543597 cellular tumor antigen p53 isoform h ORF Sequence $199.00
NM_001276696, 454544285 NP_001263625, 454544286 cellular tumor antigen p53 isoform i ORF Sequence $199.00
NM_001276697, 454544714 NP_001263626, 454544715 cellular tumor antigen p53 isoform j ORF Sequence $159.00
NM_001276698, 454545206 NP_001263627, 454545207 cellular tumor antigen p53 isoform k ORF Sequence $159.00
NM_001276699, 454545706 NP_001263628, 454545707 cellular tumor antigen p53 isoform l ORF Sequence $159.00
NM_001276760, 454520872 NP_001263689, 454520873 cellular tumor antigen p53 isoform g ORF Sequence $269.00
NM_001276761, 454521556 NP_001263690, 454521557 cellular tumor antigen p53 isoform g ORF Sequence $269.00
KEGG
hsa04110Cell cycle
hsa04310Wnt signaling pathway
hsa04010MAPK signaling pathway
hsa04115p53 signaling pathway
hsa04210Apoptosis
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05218Melanoma
hsa05213Endometrial cancer
hsa05215Prostate cancer
hsa05212Pancreatic cancer
hsa05214Glioma
hsa05016Huntington's disease
hsa05222Small cell lung cancer
hsa05217Basal cell carcinoma
hsa05219Bladder cancer
hsa05200Pathways in cancer
hsa05210Colorectal cancer
hsa05216Thyroid cancer
hsa05220Chronic myeloid leukemia
hsa05223Non-small cell lung cancer
hsa04722Neurotrophin signaling pathway
hsa05160Hepatitis C
hsa05166HTLV-I infection
hsa05162Measles
hsa05168Herpes simplex infection
hsa04151PI3K-Akt signaling pathway
hsa05161Hepatitis B
hsa05202Transcriptional misregulation in cancer
hsa05205Proteoglycans in cancer
hsa05169Epstein-Barr virus infection
hsa05203Viral carcinogenesis
hsa05206MicroRNAs in cancer
hsa04919Thyroid hormone signaling pathway
WikiPathways
WP382MAPK signaling pathway
WP254Apoptosis
WP1984Integrated Breast Cancer Pathway
WP366TGF-beta Receptor Signaling Pathway
WP615Senescence and Autophagy
WP45G1 to S cell cycle control
WP1601Fluoropyrimidine Activity
WP707DNA damage response
WP179Cell cycle
WP399Wnt Signaling Pathway and Pluripotency
WP61Delta-Notch Signaling Pathway
WP710DNA damage response (only ATM dependent)
WP673ErbB signaling pathway
WP1403AMPK signaling
WP1742TP53 network
WP1545miRNAs involved in DDR
WP2374Oncostatin M Signaling Pathway
WP2377Integrated Pancreatic Cancer Pathway
WP1971Integrated Cancer pathway
WP2261Signaling Pathways in Glioblastoma
WP2059Alzheimers Disease
WP2431Spinal Cord Injury
WP2263Prostate Cancer
WP2363Gastric cancer network 2
WP2447Amyotrophic lateral sclerosis (ALS)
WP2446RB in Cancer
Pathway Interaction Database
p53downstreampathwayDirect p53 effectors
aurora_a_pathwayAurora A signaling
hdac_classiii_pathwaySignaling events mediated by HDAC Class III
bard1pathwayBARD1 signaling events
lkb1_pathwayLKB1 signaling events
reg_gr_pathwayGlucocorticoid receptor regulatory network
hif1apathwayHypoxic and oxygen homeostasis regulation of HIF-1-alpha
p38alphabetadownstreampathwaySignaling mediated by p38-alpha and p38-beta
plk3_pathwayPLK3 signaling events
p53regulationpathwayp53 pathway
p75ntrpathwayp75(NTR)-mediated signaling
myc_activpathwayValidated targets of C-MYC transcriptional activation
Reactome
REACT_578Apoptosis
REACT_964Intrinsic Pathway for Apoptosis
REACT_202Transcriptional activation of p53 responsive genes
REACT_346Transcriptional activation of cell cycle inhibitor p21
REACT_697Activation of BH3-only proteins
REACT_2254G1/S DNA Damage Checkpoints
REACT_1194Activation of NOXA and translocation to mitochondria
REACT_121Activation of PUMA and translocation to mitochondria
REACT_309Stabilization of p53
REACT_85p53-Dependent G1/S DNA damage checkpoint
REACT_1538Cell Cycle Checkpoints
REACT_1625p53-Dependent G1 DNA Damage Response
REACT_604Hemostasis
REACT_299Signaling by NOTCH
REACT_20549Autodegradation of the E3 ubiquitin ligase COP1
REACT_24970Factors involved in megakaryocyte development and platelet production
REACT_111102Signal Transduction
REACT_115566Cell Cycle
REACT_118744Pre-NOTCH Expression and Processing
REACT_118568Pre-NOTCH Transcription and Translation
REACT_120956Cellular responses to stress
REACT_169274Cellular Senescence
REACT_169121Formation of Senescence-Associated Heterochromatin Foci (SAHF)
REACT_169436Oxidative Stress Induced Senescence
REACT_169325Oncogene Induced Senescence
REACT_169185DNA Damage/Telomere Stress Induced Senescence
Homo sapiens (human)TP53NP_000537.3
Pan troglodytes (chimpanzee)TP53XP_001172077.2
Macaca mulatta (Rhesus monkey)TP53NP_001040616.1
Canis lupus familiaris (dog)TP53NP_001003210.1
Bos taurus (cattle)TP53NP_776626.1
Mus musculus (house mouse)Trp53NP_035770.2
Rattus norvegicus (Norway rat)Tp53NP_112251.2
Danio rerio (zebrafish)tp53NP_001258749.1
Xenopus (Silurana) tropicalis (western clawed frog)tp53NP_001001903.1
Process
IDNameEvidence
GO:0000060protein import into nucleus, translocationIEA
GO:0000122negative regulation of transcription from RNA polymerase II promoterIBA
GO:0000122negative regulation of transcription from RNA polymerase II promoterIDA
GO:0000122negative regulation of transcription from RNA polymerase II promoterISS
GO:0000733DNA strand renaturationIDA
GO:0001701in utero embryonic developmentIEA
GO:0001756somitogenesisIEA
GO:0001836release of cytochrome c from mitochondriaIEA
GO:0002309T cell proliferation involved in immune responseIEA
GO:0002326B cell lineage commitmentIEA
GO:0002360T cell lineage commitmentIEA
GO:0002931response to ischemiaIEA
GO:0006284base-excision repairTAS
GO:0006289nucleotide-excision repairIMP
GO:0006302double-strand break repairIEA
GO:0006355regulation of transcription, DNA-templatedIDA
GO:0006461protein complex assemblyIDA
GO:0006915apoptotic processTAS
GO:0006974cellular response to DNA damage stimulusIDA
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestTAS
GO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorIMP
GO:0006983ER overload responseIDA
GO:0007050cell cycle arrestIDA
GO:0007050cell cycle arrestIMP
GO:0007179transforming growth factor beta receptor signaling pathwayIEA
GO:0007219Notch signaling pathwayTAS
GO:0007265Ras protein signal transductionIEP
GO:0007275multicellular organismal developmentIMP
GO:0007369gastrulationIEA
GO:0007406negative regulation of neuroblast proliferationIEA
GO:0007417central nervous system developmentIEA
GO:0007569cell agingIMP
GO:0007596blood coagulationTAS
GO:0008104protein localizationIDA
GO:0008156negative regulation of DNA replicationIEA
GO:0008283cell proliferationTAS
GO:0008285negative regulation of cell proliferationISS
GO:0008340determination of adult lifespanISS
GO:0009303rRNA transcriptionIEA
GO:0009651response to salt stressIEA
GO:0010165response to X-rayIBA
GO:0010332response to gamma radiationIMP
GO:0010666positive regulation of cardiac muscle cell apoptotic processIEA
GO:0016032viral processIEA
GO:0030154cell differentiationTAS
GO:0030308negative regulation of cell growthIMP
GO:0030330DNA damage response, signal transduction by p53 class mediatorIDA
GO:0030330DNA damage response, signal transduction by p53 class mediatorIMP
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathwayIEA
GO:0031065positive regulation of histone deacetylationIBA
GO:0031497chromatin assemblyIDA
GO:0031571mitotic G1 DNA damage checkpointIMP
GO:0032461positive regulation of protein oligomerizationIDA
GO:0033077T cell differentiation in thymusIEA
GO:0034103regulation of tissue remodelingIEA
GO:0034613cellular protein localizationIDA
GO:0034644cellular response to UVIBA
GO:0035264multicellular organism growthIEA
GO:0035690cellular response to drugIEP
GO:0042149cellular response to glucose starvationIDA
GO:0042771intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorIDA
GO:0042981regulation of apoptotic processIDA
GO:0043065positive regulation of apoptotic processIDA
GO:0043066negative regulation of apoptotic processIDA
GO:0043066negative regulation of apoptotic processIEA
GO:0043525positive regulation of neuron apoptotic processIBA
GO:0045892negative regulation of transcription, DNA-templatedISS
GO:0045893positive regulation of transcription, DNA-templatedIDA
GO:0045893positive regulation of transcription, DNA-templatedIMP
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIGI
GO:0045944positive regulation of transcription from RNA polymerase II promoterIMP
GO:0046677response to antibioticIEP
GO:0046902regulation of mitochondrial membrane permeabilityTAS
GO:0048147negative regulation of fibroblast proliferationIMP
GO:0048568embryonic organ developmentIEA
GO:0050731positive regulation of peptidyl-tyrosine phosphorylationISS
GO:0051097negative regulation of helicase activityTAS
GO:0051262protein tetramerizationTAS
GO:0051402neuron apoptotic processIEA
GO:0070245positive regulation of thymocyte apoptotic processISS
GO:0071158positive regulation of cell cycle arrestIMP
GO:0071456cellular response to hypoxiaIEP
GO:0071479cellular response to ionizing radiationIMP
GO:0071850mitotic cell cycle arrestIEA
GO:0072332intrinsic apoptotic signaling pathway by p53 class mediatorIMP
GO:0090200positive regulation of release of cytochrome c from mitochondriaIDA
GO:0090343positive regulation of cell agingIEA
GO:0090399replicative senescenceIMP
GO:0090403oxidative stress-induced premature senescenceIMP
GO:0097193intrinsic apoptotic signaling pathwayTAS
GO:0097252oligodendrocyte apoptotic processIDA
GO:1900740positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathwayTAS
GO:1901525negative regulation of macromitophagyIEA
GO:1902108regulation of mitochondrial membrane permeability involved in apoptotic processIEA
GO:2000378negative regulation of reactive oxygen species metabolic processIEA
GO:2000379positive regulation of reactive oxygen species metabolic processIMP
GO:2001244positive regulation of intrinsic apoptotic signaling pathwayIMP
Component
IDNameEvidence
GO:0000785chromatinIBA
GO:0000790nuclear chromatinIDA
GO:0005634nucleusIDA
GO:0005654nucleoplasmIDA
GO:0005654nucleoplasmTAS
GO:0005657replication forkIBA
GO:0005669transcription factor TFIID complexIDA
GO:0005730nucleolusIDA
GO:0005737cytoplasmIDA
GO:0005739mitochondrionIDA
GO:0005759mitochondrial matrixIEA
GO:0005783endoplasmic reticulumIEA
GO:0005829cytosolIBA
GO:0005829cytosolIDA
GO:0016363nuclear matrixIDA
GO:0016604nuclear bodyIDA
GO:0016605PML bodyIDA
GO:0043234protein complexIDA
Function
IDNameEvidence
GO:0000979RNA polymerase II core promoter sequence-specific DNA bindingIEA
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIEA
GO:0001085RNA polymerase II transcription factor bindingIPI
GO:0001228RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIDA
GO:0002020protease bindingIPI
GO:0002039p53 bindingIBA
GO:0003677DNA bindingIMP
GO:0003682chromatin bindingIDA
GO:0003684damaged DNA bindingIBA
GO:0003700sequence-specific DNA binding transcription factor activityIDA
GO:0005507copper ion bindingIDA
GO:0005515protein bindingIPI
GO:0005524ATP bindingIDA
GO:0008134transcription factor bindingIPI
GO:0008270zinc ion bindingTAS
GO:0019899enzyme bindingIPI
GO:0019901protein kinase bindingIPI
GO:0019903protein phosphatase bindingIPI
GO:0030971receptor tyrosine kinase bindingIPI
GO:0031625ubiquitin protein ligase bindingIPI
GO:0035033histone deacetylase regulator activityIEA
GO:0035035histone acetyltransferase bindingIPI
GO:0042802identical protein bindingIPI
GO:0044212transcription regulatory region DNA bindingIDA
GO:0046982protein heterodimerization activityIPI
GO:0047485protein N-terminus bindingIPI
GO:0051087chaperone bindingIPI
GO:0051721protein phosphatase 2A bindingIPI
GO:0097371MDM2/MDM4 family protein bindingIEA
GeneCards TP53
UniProt K7PPA8, Q53GA5, H2EHT1, P04637
Vega OTTHUMG00000162125
MIM 191170
Ensembl ENSG00000141510
HGNC 11998
HPRD 01859

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the TP53 gene?

The TP53 gene provides instructions for making a protein called tumor protein p53. This protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells from growing and dividing too fast or in an uncontrolled way.

Tumor protein p53 is located in the nucleus of cells throughout the body, where it binds directly to DNA. When the DNA in a cell becomes damaged by agents such as toxic chemicals, radiation, or ultraviolet (UV) rays from sunlight, this protein plays a critical role in determining whether the DNA will be repaired or the damaged cell will self-destruct (undergo apoptosis). If the DNA can be repaired, tumor protein p53 activates other genes to fix the damage. If the DNA cannot be repaired, this protein prevents the cell from dividing and signals it to undergo apoptosis. This process prevents cells with mutated or damaged DNA from dividing, which helps prevent the development of tumors.

Because tumor protein p53 is essential for regulating cell division and preventing tumor formation, it has been nicknamed the "guardian of the genome."

Interactant

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.