• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


TP53 tumor protein p53 [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_000546 Homo sapiens tumor protein p53 (TP53), transcript variant 1, mRNA. ORF Sequence $342.78
Peptide Services
Antibody Services
Protein Services
NM_001126112 Homo sapiens tumor protein p53 (TP53), transcript variant 2, mRNA. ORF Sequence $342.78
Peptide Services
Antibody Services
Protein Services
NM_001126113 Homo sapiens tumor protein p53 (TP53), transcript variant 4, mRNA. ORF Sequence $301.89
Peptide Services
Antibody Services
Protein Services
NM_001126114 Homo sapiens tumor protein p53 (TP53), transcript variant 3, mRNA. ORF Sequence $297.54
Peptide Services
Antibody Services
Protein Services
NM_001126115 Homo sapiens tumor protein p53 (TP53), transcript variant 5, mRNA. ORF Sequence $227.94
Peptide Services
Antibody Services
Protein Services
NM_001126116 Homo sapiens tumor protein p53 (TP53), transcript variant 6, mRNA. ORF Sequence $182.70
Peptide Services
Antibody Services
Protein Services
NM_001126117 Homo sapiens tumor protein p53 (TP53), transcript variant 7, mRNA. ORF Sequence $187.05
Peptide Services
Antibody Services
Protein Services
NM_001126118 Homo sapiens tumor protein p53 (TP53), transcript variant 8, mRNA. ORF Sequence $308.85
Peptide Services
Antibody Services
Protein Services
NM_001276695 Homo sapiens tumor protein p53 (TP53), transcript variant 4, mRNA. ORF Sequence $267.96
Peptide Services
Antibody Services
Protein Services
NM_001276696 Homo sapiens tumor protein p53 (TP53), transcript variant 3, mRNA. ORF Sequence $263.61
Peptide Services
Antibody Services
Protein Services
NM_001276697 Homo sapiens tumor protein p53 (TP53), transcript variant 5, mRNA. ORF Sequence $204.45
Peptide Services
Antibody Services
Protein Services
NM_001276698 Homo sapiens tumor protein p53 (TP53), transcript variant 6, mRNA. ORF Sequence $159.21
Peptide Services
Antibody Services
Protein Services
NM_001276699 Homo sapiens tumor protein p53 (TP53), transcript variant 7, mRNA. ORF Sequence $163.56
Peptide Services
Antibody Services
Protein Services
NM_001276760 Homo sapiens tumor protein p53 (TP53), transcript variant 1, mRNA. ORF Sequence $308.85
Peptide Services
Antibody Services
Protein Services
NM_001276761 Homo sapiens tumor protein p53 (TP53), transcript variant 2, mRNA. ORF Sequence $308.85
Peptide Services
Antibody Services
Protein Services


Gene Symbol TP53
Entrez Gene ID 7157
Full Name tumor protein p53
Synonyms FLJ92943, LFS1, P53, TRP53
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17p13.1

Summary This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013].
Disorder

MIM: 191170

Colorectal cancer, 114500 (3); Li-Fraumeni syndrome, 151623 (3);

mRNA Protein Product Sequence Price Select
NM_000546, 371502114 NP_000537, 120407068 cellular tumor antigen p53 isoform a Full Length $751.39
ORF Sequence $342.78
NM_001126112, 371502115 NP_001119584, 187830777 cellular tumor antigen p53 isoform a Full Length $750.52
ORF Sequence $342.78
NM_001126113, 371502116 NP_001119585, 187830823 cellular tumor antigen p53 isoform c Full Length $768.79
ORF Sequence $301.89
NM_001126114, 371502117 NP_001119586, 187830855 cellular tumor antigen p53 isoform b Full Length $789.96
ORF Sequence $297.54
NM_001126115, 187830893 NP_001119587, 187830894 cellular tumor antigen p53 isoform d Full Length $658.59
ORF Sequence $227.94
NM_001126116, 187830900 NP_001119588, 187830901 cellular tumor antigen p53 isoform e Full Length $697.16
ORF Sequence $182.70
NM_001126117, 187830908 NP_001119589, 187830909 cellular tumor antigen p53 isoform f Full Length $675.99
ORF Sequence $187.05
NM_001126118, 371502118 NP_001119590, 371502119 cellular tumor antigen p53 isoform g Full Length $785.32
ORF Sequence $308.85
NM_001276695, 454543596 NP_001263624, 454543597 cellular tumor antigen p53 isoform h Full Length $768.79
ORF Sequence $267.96
NM_001276696, 454544285 NP_001263625, 454544286 cellular tumor antigen p53 isoform i Full Length $789.96
ORF Sequence $263.61
NM_001276697, 454544714 NP_001263626, 454544715 cellular tumor antigen p53 isoform j Full Length $658.59
ORF Sequence $204.45
NM_001276698, 454545206 NP_001263627, 454545207 cellular tumor antigen p53 isoform k Full Length $697.16
ORF Sequence $159.21
NM_001276699, 454545706 NP_001263628, 454545707 cellular tumor antigen p53 isoform l Full Length $675.99
ORF Sequence $163.56
NM_001276760, 454520872 NP_001263689, 454520873 cellular tumor antigen p53 isoform g Full Length $751.39
ORF Sequence $308.85
NM_001276761, 454521556 NP_001263690, 454521557 cellular tumor antigen p53 isoform g Full Length $750.52
ORF Sequence $308.85
KEGG
hsa04210Apoptosis
hsa04115p53 signaling pathway
hsa05213Endometrial cancer
hsa05200Pathways in cancer
hsa04010MAPK signaling pathway
hsa05217Basal cell carcinoma
hsa04310Wnt signaling pathway
hsa05016Huntington's disease
hsa05223Non-small cell lung cancer
hsa04722Neurotrophin signaling pathway
hsa05166HTLV-I infection
hsa05216Thyroid cancer
hsa05202Transcriptional misregulation in cancer
hsa05169Epstein-Barr virus infection
hsa04151PI3K-Akt signaling pathway
hsa05215Prostate cancer
hsa05220Chronic myeloid leukemia
hsa05222Small cell lung cancer
hsa04110Cell cycle
hsa05218Melanoma
hsa05214Glioma
hsa05161Hepatitis B
hsa05162Measles
hsa05160Hepatitis C
hsa05168Herpes simplex infection
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05210Colorectal cancer
hsa05219Bladder cancer
hsa05203Viral carcinogenesis
hsa05212Pancreatic cancer
Pathway Interaction Database
aurora_a_pathwayAurora A signaling
p38alphabetadownstreampathwaySignaling mediated by p38-alpha and p38-beta
p53downstreampathwayDirect p53 effectors
p75ntrpathwayp75(NTR)-mediated signaling
reg_gr_pathwayGlucocorticoid receptor regulatory network
lkb1_pathwayLKB1 signaling events
bard1pathwayBARD1 signaling events
hif1apathwayHypoxic and oxygen homeostasis regulation of HIF-1-alpha
myc_activpathwayValidated targets of C-MYC transcriptional activation
p53regulationpathwayp53 pathway
hdac_classiii_pathwaySignaling events mediated by HDAC Class III
plk3_pathwayPLK3 signaling events
WikiPathways
WP2261Signaling Pathways in Glioblastoma
WP1601Fluoropyrimidine Activity
WP179Cell cycle
WP615Senescence and Autophagy
WP1403AMPK signaling
WP1545miRNAs involved in DDR
WP673ErbB signaling pathway
WP707DNA damage response
WP1742TP53 network
WP2374Oncostatin M Signaling Pathway
WP1971Integrated Cancer pathway
WP710DNA damage response (only ATM dependent)
WP61Delta-Notch Signaling Pathway
WP1984Integrated Breast Cancer Pathway
WP382MAPK signaling pathway
WP45G1 to S cell cycle control
WP2059Alzheimers Disease
WP366TGF-beta Receptor Signaling Pathway
WP399Wnt Signaling Pathway and Pluripotency
WP254Apoptosis
WP2256Integrated Pancreatic Cancer Pathway
WP2377Integrated Pancreatic Cancer Pathway
Reactome
REACT_346Transcriptional activation of cell cycle inhibitor p21
REACT_1538Cell Cycle Checkpoints
REACT_24970Factors involved in megakaryocyte development and platelet production
REACT_111102Signal Transduction
REACT_85p53-Dependent G1/S DNA damage checkpoint
REACT_697Activation of BH3-only proteins
REACT_309Stabilization of p53
REACT_115566Cell Cycle
REACT_118568Pre-NOTCH Transcription and Translation
REACT_299Signaling by NOTCH
REACT_964Intrinsic Pathway for Apoptosis
REACT_20549Autodegradation of the E3 ubiquitin ligase COP1
REACT_578Apoptosis
REACT_2254G1/S DNA Damage Checkpoints
REACT_604Hemostasis
REACT_1194Activation of NOXA and translocation to mitochondria
REACT_121Activation of PUMA and translocation to mitochondria
REACT_1625p53-Dependent G1 DNA Damage Response
REACT_118744Pre-NOTCH Expression and Processing
REACT_202Transcriptional activation of p53 responsive genes
Homo sapiens (human)TP53NP_000537.3
Pan troglodytes (chimpanzee)TP53XP_001172077.2
Macaca mulatta (Rhesus monkey)TP53NP_001040616.1
Canis lupus familiaris (dog)TP53NP_001003210.1
Bos taurus (cattle)TP53NP_776626.1
Mus musculus (house mouse)Trp53NP_035770.2
Rattus norvegicus (Norway rat)Tp53NP_112251.2
Danio rerio (zebrafish)tp53NP_571402.1

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
cellular tumor antigen p53
Names
cellular tumor antigen p53
antigen NY-CO-13
phosphoprotein p53
p53 tumor suppressor
transformation-related protein 53

Interactant

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.

Secured Online Quotation
Email: gene@genscript.com
Phone: 1-877-436-7274 (Toll-Free) 1-732-885-9188
Fax: 1-732-210-0262 1-732-885-5878