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TPM1 tropomyosin 1 (alpha) [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000366 Homo sapiens tropomyosin 1 (alpha) (TPM1), transcript variant 5, mRNA. GenEZ ORF Cloning In-stock $348.00 $299.00 10
NM_001018004 Homo sapiens tropomyosin 1 (alpha) (TPM1), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $449.00 14
NM_001018005 Homo sapiens tropomyosin 1 (alpha) (TPM1), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $348.00 $299.00 10
NM_001018006 Homo sapiens tropomyosin 1 (alpha) (TPM1), transcript variant 4, mRNA. GenEZ ORF Cloning On-demand $449.00 14
NM_001018007 Homo sapiens tropomyosin 1 (alpha) (TPM1), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $449.00 14
NM_001018008 Homo sapiens tropomyosin 1 (alpha) (TPM1), transcript variant 6, mRNA. GenEZ ORF Cloning On-demand $399.00 14
NM_001018020 Homo sapiens tropomyosin 1 (alpha) (TPM1), transcript variant 7, mRNA. GenEZ ORF Cloning On-demand $449.00 14
XM_005254637 PREDICTED: Homo sapiens tropomyosin 1 (alpha) (TPM1), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $549.00 14
XM_005254638 PREDICTED: Homo sapiens tropomyosin 1 (alpha) (TPM1), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand $449.00 14
XM_005254639 PREDICTED: Homo sapiens tropomyosin 1 (alpha) (TPM1), transcript variant X4, mRNA. GenEZ ORF Cloning On-demand $449.00 14
XM_005254640 PREDICTED: Homo sapiens tropomyosin 1 (alpha) (TPM1), transcript variant X5, mRNA. GenEZ ORF Cloning On-demand $449.00 14
XM_005254641 PREDICTED: Homo sapiens tropomyosin 1 (alpha) (TPM1), transcript variant X6, mRNA. GenEZ ORF Cloning On-demand $449.00 14
XM_005254643 PREDICTED: Homo sapiens tropomyosin 1 (alpha) (TPM1), transcript variant X8, mRNA. GenEZ ORF Cloning On-demand $449.00 14
XM_005254644 PREDICTED: Homo sapiens tropomyosin 1 (alpha) (TPM1), transcript variant X9, mRNA. GenEZ ORF Cloning On-demand $449.00 14
XM_005254645 PREDICTED: Homo sapiens tropomyosin 1 (alpha) (TPM1), transcript variant X10, mRNA. GenEZ ORF Cloning On-demand $449.00 14
XM_005254646 PREDICTED: Homo sapiens tropomyosin 1 (alpha) (TPM1), transcript variant X11, mRNA. GenEZ ORF Cloning On-demand $449.00 14
XM_005254647 PREDICTED: Homo sapiens tropomyosin 1 (alpha) (TPM1), transcript variant X12, mRNA. GenEZ ORF Cloning On-demand $449.00 14
XM_005254648 PREDICTED: Homo sapiens tropomyosin 1 (alpha) (TPM1), transcript variant X13, mRNA. GenEZ ORF Cloning On-demand $399.00 14
XM_005254649 PREDICTED: Homo sapiens tropomyosin 1 (alpha) (TPM1), transcript variant X14, mRNA. GenEZ ORF Cloning On-demand $399.00 14
XM_005254650 PREDICTED: Homo sapiens tropomyosin 1 (alpha) (TPM1), transcript variant X15, mRNA. GenEZ ORF Cloning On-demand $399.00 14
XM_005254651 PREDICTED: Homo sapiens tropomyosin 1 (alpha) (TPM1), transcript variant X16, mRNA. GenEZ ORF Cloning On-demand $399.00 14
XM_005254652 PREDICTED: Homo sapiens tropomyosin 1 (alpha) (TPM1), transcript variant X17, mRNA. GenEZ ORF Cloning On-demand $399.00 14
XM_005254653 PREDICTED: Homo sapiens tropomyosin 1 (alpha) (TPM1), transcript variant X18, mRNA. GenEZ ORF Cloning On-demand $399.00 14
XM_006720667 PREDICTED: Homo sapiens tropomyosin 1 (alpha) (TPM1), transcript variant X19, mRNA. GenEZ ORF Cloning On-demand $449.00 14
XM_006720668 PREDICTED: Homo sapiens tropomyosin 1 (alpha) (TPM1), transcript variant X20, mRNA. GenEZ ORF Cloning On-demand $449.00 14
XM_006720669 PREDICTED: Homo sapiens tropomyosin 1 (alpha) (TPM1), transcript variant X21, mRNA. GenEZ ORF Cloning On-demand $399.00 14

*Business Day

Related Services

Gene Symbol TPM1
Entrez Gene ID 7168
Full Name tropomyosin 1 (alpha)
Synonyms C15orf13, CMD1Y, CMH3, HTM-alpha, LVNC9, TMSA
General protein information
Preferred Names
tropomyosin alpha-1 chain
Names
tropomyosin alpha-1 chain
alpha-tropomyosin
sarcomeric tropomyosin kappa
cardiomyopathy, hypertrophic 3
tropomyosin 1 (alpha) isoform 1
tropomyosin 1 (alpha) isoform 2
tropomyosin 1 (alpha) isoform 3
tropomyosin 1 (alpha) isoform 4
tropomyosin 1 (alpha) isoform 5
tropomyosin 1 (alpha) isoform 6
tropomyosin 1 (alpha) isoform 7
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

15

15q22.1

Summary This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008].
Disorder

MIM: 191010

Cardiomyopathy, familial hypertrophic, 3, 115196 (3); Cardiomyopathy,

mRNA Protein Product Sequence Price Select
NM_000366, 63252894 NP_000357, 27597085 tropomyosin alpha-1 chain isoform 5 ORF Sequence $199.00
NM_001018004, 63252895 NP_001018004, 63252896 tropomyosin alpha-1 chain isoform 3 ORF Sequence $300.00
NM_001018005, 63252897 NP_001018005, 63252898 tropomyosin alpha-1 chain isoform 1 ORF Sequence $199.00
NM_001018006, 63252899 NP_001018006, 63252900 tropomyosin alpha-1 chain isoform 4 ORF Sequence $300.00
NM_001018007, 63252901 NP_001018007, 63252902 tropomyosin alpha-1 chain isoform 2 ORF Sequence $300.00
NM_001018008, 63252903 NP_001018008, 63252904 tropomyosin alpha-1 chain isoform 6 ORF Sequence $250.00
NM_001018020, 63252905 NP_001018020, 63252906 tropomyosin alpha-1 chain isoform 7 ORF Sequence $300.00
XM_005254637, 530406385 XP_005254694, 530406386 tropomyosin alpha-1 chain isoform X2 ORF Sequence $400.00
XM_005254638, 530406387 XP_005254695, 530406388 tropomyosin alpha-1 chain isoform X3 ORF Sequence $300.00
XM_005254639, 530406389 XP_005254696, 530406390 tropomyosin alpha-1 chain isoform X4 ORF Sequence $300.00
XM_005254640, 530406391 XP_005254697, 530406392 tropomyosin alpha-1 chain isoform X5 ORF Sequence $300.00
XM_005254641, 530406393 XP_005254698, 530406394 tropomyosin alpha-1 chain isoform X6 ORF Sequence $300.00
XM_005254643, 530406397 XP_005254700, 530406398 tropomyosin alpha-1 chain isoform X8 ORF Sequence $300.00
XM_005254644, 530406399 XP_005254701, 530406400 tropomyosin alpha-1 chain isoform X9 ORF Sequence $300.00
XM_005254645, 530406401 XP_005254702, 530406402 tropomyosin alpha-1 chain isoform X10 ORF Sequence $300.00
XM_005254646, 530406403 XP_005254703, 530406404 tropomyosin alpha-1 chain isoform X11 ORF Sequence $300.00
XM_005254647, 530406405 XP_005254704, 530406406 tropomyosin alpha-1 chain isoform X12 ORF Sequence $300.00
XM_005254648, 530406407 XP_005254705, 530406408 tropomyosin alpha-1 chain isoform X13 ORF Sequence $250.00
XM_005254649, 530406409 XP_005254706, 530406410 tropomyosin alpha-1 chain isoform X14 ORF Sequence $250.00
XM_005254650, 530406411 XP_005254707, 530406412 tropomyosin alpha-1 chain isoform X15 ORF Sequence $250.00
XM_005254651, 530406413 XP_005254708, 530406414 tropomyosin alpha-1 chain isoform X16 ORF Sequence $250.00
XM_005254652, 530406415 XP_005254709, 530406416 tropomyosin alpha-1 chain isoform X17 ORF Sequence $250.00
XM_005254653, 530406417 XP_005254710, 530406418 tropomyosin alpha-1 chain isoform X18 ORF Sequence $250.00
XM_006720667, 578827354 XP_006720730, 578827355 tropomyosin alpha-1 chain isoform X19 ORF Sequence $300.00
XM_006720668, 578827356 XP_006720731, 578827357 tropomyosin alpha-1 chain isoform X20 ORF Sequence $300.00
XM_006720669, 578827358 XP_006720732, 578827359 tropomyosin alpha-1 chain isoform X21 ORF Sequence $250.00
KEGG
hsa04260Cardiac muscle contraction
hsa05414Dilated cardiomyopathy
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05206MicroRNAs in cancer
hsa04261Adrenergic signaling in cardiomyocytes
WikiPathways
WP383Striated Muscle Contraction
Reactome
REACT_17044Muscle contraction
REACT_16969Striated Muscle Contraction
REACT_20558Smooth Muscle Contraction
Homo sapiens (human)TPM1NP_001018004.1
Pan troglodytes (chimpanzee)TPM1XP_001173556.2
Macaca mulatta (Rhesus monkey)TPM1XP_001104296.1
Bos taurus (cattle)TPM1NP_001013608.1
Gallus gallus (chicken)TPM1NP_990732.1
Danio rerio (zebrafish)tpm2NP_001002119.1
Drosophila melanogaster (fruit fly)Tm1NP_732001.3
Caenorhabditis eleganslev-11NP_001021695.1
Process
IDNameEvidence
GO:0001701in utero embryonic developmentIEA
GO:0003065positive regulation of heart rate by epinephrineISS
GO:0006928cellular component movementTAS
GO:0006936muscle contractionTAS
GO:0006937regulation of muscle contractionTAS
GO:0007010cytoskeleton organizationTAS
GO:0008016regulation of heart contractionTAS
GO:0030049muscle filament slidingISS
GO:0030049muscle filament slidingTAS
GO:0030336negative regulation of cell migrationISS
GO:0031529ruffle organizationISS
GO:0032781positive regulation of ATPase activityISS
GO:0034614cellular response to reactive oxygen speciesIEP
GO:0042060wound healingISS
GO:0045214sarcomere organizationIMP
GO:0045785positive regulation of cell adhesionISS
GO:0051496positive regulation of stress fiber assemblyISS
GO:0055010ventricular cardiac muscle tissue morphogenesisIMP
GO:0060048cardiac muscle contractionIMP
Component
IDNameEvidence
GO:0001725stress fiberIDA
GO:0005829cytosolTAS
GO:0005856cytoskeletonTAS
GO:0005862muscle thin filament tropomyosinTAS
GO:0030017sarcomereTAS
GO:0031941filamentous actinIEA
GO:0032059blebIMP
GO:0032587ruffle membraneIDA
Function
IDNameEvidence
GO:0003779actin bindingTAS
GO:0005200structural constituent of cytoskeletonTAS
GO:0008092cytoskeletal protein bindingIPI
GO:0008307structural constituent of muscleTAS
GeneCards TPM1
UniProt Q6ZN40, D9YZV7, B7Z596, O15513, D9YZV5, P09493, F5H7S3, D9YZV4, B7Z722, H7BYY1
Vega OTTHUMG00000132803
MIM 191010
Ensembl ENSG00000140416
HGNC 12010
HPRD 01839

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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