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TPM1 tropomyosin 1 (alpha) [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_000366 Homo sapiens tropomyosin 1 (alpha) (TPM1), transcript variant 5, mRNA. ORF Sequence $247.95
Peptide Services
Antibody Services
Protein Services
NM_001018004 Homo sapiens tropomyosin 1 (alpha) (TPM1), transcript variant 3, mRNA. ORF Sequence $247.95
Peptide Services
Antibody Services
Protein Services
NM_001018005 Homo sapiens tropomyosin 1 (alpha) (TPM1), transcript variant 1, mRNA. ORF Sequence $247.95
Peptide Services
Antibody Services
Protein Services
NM_001018006 Homo sapiens tropomyosin 1 (alpha) (TPM1), transcript variant 4, mRNA. ORF Sequence $247.95
Peptide Services
Antibody Services
Protein Services
NM_001018007 Homo sapiens tropomyosin 1 (alpha) (TPM1), transcript variant 2, mRNA. ORF Sequence $247.95
Peptide Services
Antibody Services
Protein Services
NM_001018008 Homo sapiens tropomyosin 1 (alpha) (TPM1), transcript variant 6, mRNA. ORF Sequence $214.02
Peptide Services
Antibody Services
Protein Services
NM_001018020 Homo sapiens tropomyosin 1 (alpha) (TPM1), transcript variant 7, mRNA. ORF Sequence $247.95
Peptide Services
Antibody Services
Protein Services


Gene Symbol TPM1
Entrez Gene ID 7168
Full Name tropomyosin 1 (alpha)
Synonyms C15orf13, CMD1Y, CMH3, HTM-alpha, TMSA
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

15

15q22.1

Summary This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008].
Disorder

MIM: 191010

Cardiomyopathy, familial hypertrophic, 3, 115196 (3); Cardiomyopathy,

mRNA Protein Product Sequence Price Select
NM_000366, 63252894 NP_000357, 27597085 tropomyosin alpha-1 chain isoform 5 Full Length $375.26
ORF Sequence $247.95
NM_001018004, 63252895 NP_001018004, 63252896 tropomyosin alpha-1 chain isoform 3 Full Length $521.13
ORF Sequence $247.95
NM_001018005, 63252897 NP_001018005, 63252898 tropomyosin alpha-1 chain isoform 1 Full Length $361.34
ORF Sequence $247.95
NM_001018006, 63252899 NP_001018006, 63252900 tropomyosin alpha-1 chain isoform 4 Full Length $521.13
ORF Sequence $247.95
NM_001018007, 63252901 NP_001018007, 63252902 tropomyosin alpha-1 chain isoform 2 Full Length $521.13
ORF Sequence $247.95
NM_001018008, 63252903 NP_001018008, 63252904 tropomyosin alpha-1 chain isoform 6 Full Length $454.14
ORF Sequence $214.02
NM_001018020, 63252905 NP_001018020, 63252906 tropomyosin alpha-1 chain isoform 7 Full Length $521.13
ORF Sequence $247.95
KEGG
hsa05414Dilated cardiomyopathy
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa04260Cardiac muscle contraction
WikiPathways
WP383Striated Muscle Contraction
Reactome
REACT_17044Muscle contraction
REACT_20558Smooth Muscle Contraction
REACT_16969Striated Muscle Contraction
Homo sapiens (human)TPM1NP_001018020.1
Pan troglodytes (chimpanzee)TPM1XP_001173584.1
Canis lupus familiaris (dog)TPM1XP_864981.1
Gallus gallus (chicken)TPM1NP_990732.1
GeneCards TPM1
UniProt D9YZV7, O15513, D9YZV5, P09493, D9YZV2, D9YZV3, D9YZV4, D9YZV8
MIM 191010
Ensembl ENSG00000140416
HGNC 12010
HPRD 01839

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
tropomyosin alpha-1 chain
Names
tropomyosin alpha-1 chain
alpha-tropomyosin
sarcomeric tropomyosin kappa
cardiomyopathy, hypertrophic 3
tropomyosin 1 (alpha) isoform 1
tropomyosin 1 (alpha) isoform 2
tropomyosin 1 (alpha) isoform 3
tropomyosin 1 (alpha) isoform 4
tropomyosin 1 (alpha) isoform 5
tropomyosin 1 (alpha) isoform 6
tropomyosin 1 (alpha) isoform 7

Interactant

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