TRIO triple functional domain (PTPRF interacting) [Homo sapiens (human)]
| Gene Symbol | TRIO |
| Entrez Gene ID | 7204 |
| Full Name | triple functional domain (PTPRF interacting) |
| Synonyms | ARHGEF23, FLJ42780, tgat |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
5 5p15.2 |
| Summary | |
| Disorder | MIM: 601893 |
| mRNA | NM_007118, 45439358 |
| Protein | NP_009049, 45439359 |
| Product | triple functional domain protein |
| RefSeq Status | VALIDATED |
| rhoa_reg_pathway | Regulation of RhoA activity |
| rac1_reg_pathway | Regulation of RAC1 activity |
Reactome
| REACT_22237 | Netrin-1 signaling |
| REACT_18407 | G alpha (12/13) signalling events |
| REACT_18283 | G alpha (q) signalling events |
| REACT_22351 | DCC mediated attractive signaling |
| REACT_11061 | Signalling by NGF |
| REACT_14797 | Signaling by GPCR |
| REACT_19184 | GPCR downstream signaling |
| REACT_13638 | NRAGE signals death through JNK |
| REACT_11051 | Rho GTPase cycle |
| REACT_13776 | p75 NTR receptor-mediated signalling |
| REACT_13720 | Cell death signalling via NRAGE, NRIF and NADE |
| REACT_18266 | Axon guidance |
| REACT_11044 | Signaling by Rho GTPases |
| Homo sapiens (human) | TRIO | NP_009049.2 |
| Pan troglodytes (chimpanzee) | TRIO | XP_517637.2 |
| Canis lupus familiaris (dog) | TRIO | XP_535785.2 |
| Mus musculus (house mouse) | Trio | XP_001475018.1 |
| Rattus norvegicus (Norway rat) | Trio | XP_226888.4 |
| Gallus gallus (chicken) | TRIO | XP_419004.2 |
| Danio rerio (zebrafish) | si:dkey-158b13.2 | NP_001097996.1 |
| Drosophila melanogaster (fruit fly) | trio | NP_651960.2 |
| Caenorhabditis elegans | unc-73 | NP_001021496.1 |
| ID | Name | Evidence |
| GO:0006468 | protein phosphorylation | IEA |
| GO:0006915 | apoptosis | EXP |
| GO:0007185 | transmembrane receptor protein tyrosine phosphatase signaling pathway | TAS |
| GO:0007264 | small GTPase mediated signal transduction | TAS |
| GO:0007411 | axon guidance | TAS |
| GO:0008624 | induction of apoptosis by extracellular signals | EXP |
| GO:0035023 | regulation of Rho protein signal transduction | IEA |
| GO:0048011 | nerve growth factor receptor signaling pathway | TAS |
| GO:0051056 | regulation of small GTPase mediated signal transduction | TAS |
Component
| ID | Name | Evidence |
| GO:0005622 | intracellular | IEA |
| GO:0005737 | cytoplasm | IEA |
| GO:0005829 | cytosol | EXP |
| GO:0005829 | cytosol | TAS |
Function
| ID | Name | Evidence |
| GO:0000166 | nucleotide binding | IEA |
| GO:0004674 | protein serine/threonine kinase activity | IEA |
| GO:0005085 | guanyl-nucleotide exchange factor activity | EXP |
| GO:0005089 | Rho guanyl-nucleotide exchange factor activity | TAS |
| GO:0005524 | ATP binding | IEA |
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