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TRPC6 transient receptor potential cation channel, subfamily C, member 6 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_004621 Homo sapiens transient receptor potential cation channel, subfamily C, member 6 (TRPC6), mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_006718898 PREDICTED: Homo sapiens transient receptor potential cation channel, subfamily C, member 6 (TRPC6), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $899.00 20

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Gene Symbol TRPC6
Entrez Gene ID 7225
Full Name transient receptor potential cation channel, subfamily C, member 6
Synonyms FSGS2, TRP6
General protein information
Preferred Names
short transient receptor potential channel 6
short transient receptor potential channel 6
transient receptor protein 6
Gene Type protein-coding
Organism Homo sapiens (human)



Summary The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq, Mar 2009].

MIM: 603652

Glomerulosclerosis, focal segmental, 2, 603965 (3)

mRNA Protein Product Sequence Price Select
NM_004621, 170014741 NP_004612, 5730102 short transient receptor potential channel 6 ORF Sequence $750.00
XM_006718898, 578822357 XP_006718961, 578822358 short transient receptor potential channel 6 isoform X1 ORF Sequence $750.00
hsa04022cGMP-PKG signaling pathway
Pathway Interaction Database
nephrin_neph1_pathwayNephrin/Neph1 signaling in the kidney podocyte
epopathwayEPO signaling pathway
REACT_18266Axon guidance
REACT_19184GPCR downstream signaling
REACT_18283G alpha (q) signalling events
REACT_798Platelet activation, signaling and aggregation
REACT_2202Effects of PIP2 hydrolysis
REACT_162Elevation of cytosolic Ca2+ levels
REACT_14797Signaling by GPCR
REACT_15518Transmembrane transport of small molecules
REACT_22237Netrin-1 signaling
REACT_22228Role of second messengers in netrin-1 signaling
REACT_23876Platelet homeostasis
REACT_25300Ion channel transport
REACT_23905Platelet calcium homeostasis
REACT_111045Developmental Biology
REACT_111102Signal Transduction
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_169333TRP channels
REACT_160189Stimuli-sensing channels
Homo sapiens (human)TRPC6NP_004612.2
Pan troglodytes (chimpanzee)TRPC6XP_001150152.1
Macaca mulatta (Rhesus monkey)TRPM2XP_002808133.1
Canis lupus familiaris (dog)TRPC6XP_546553.3
Bos taurus (cattle)TRPC6NP_001160044.1
Mus musculus (house mouse)Trpc6NP_038866.2
Rattus norvegicus (Norway rat)Trpc6NP_446011.1
Gallus gallus (chicken)TRPC6XP_003640636.1
Danio rerio (zebrafish)trpc6aNP_001025453.1
Danio rerio (zebrafish)LOC100333090XP_002665445.2
Caenorhabditis eleganstrp-1NP_001040889.1
Xenopus (Silurana) tropicalis (western clawed frog)trpc6XP_002935616.2
GO:0006812cation transportTAS
GO:0007204positive regulation of cytosolic calcium ion concentrationIEA
GO:0007411axon guidanceTAS
GO:0007596blood coagulationTAS
GO:0030168platelet activationTAS
GO:0032414positive regulation of ion transmembrane transporter activityIDA
GO:0034220ion transmembrane transportTAS
GO:0051928positive regulation of calcium ion transportIDA
GO:0055085transmembrane transportTAS
GO:0070301cellular response to hydrogen peroxideIEA
GO:0070588calcium ion transmembrane transportTAS
GO:0071456cellular response to hypoxiaIEA
GO:0005886plasma membraneIDA
GO:0005886plasma membraneTAS
GO:0016021integral component of membraneIEA
GO:0036057slit diaphragmIEA
GO:0005515protein bindingIPI
GO:0015279store-operated calcium channel activityIEA
GO:0070679inositol 1,4,5 trisphosphate bindingIDA
GeneCards TRPC6
UniProt Q9Y210
Vega OTTHUMG00000167483
MIM 603652
Ensembl ENSG00000137672
HGNC 12338
HPRD 04710

GeneRIFs: Gene References Into Functions What's a GeneRIF?


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