TRPC6 transient receptor potential cation channel, subfamily C, member 6 [Homo sapiens (human)]
| Gene Symbol | TRPC6 |
| Entrez Gene ID | 7225 |
| Full Name | transient receptor potential cation channel, subfamily C, member 6 |
| Synonyms | FLJ11098, FLJ14863, FSGS2, TRP6 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
11 11q22.1 |
| Summary | The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq]. |
| Disorder | MIM: 603652 Glomerulosclerosis, focal segmental, 2, 603965 (3) |
| mRNA | NM_004621, 170014741 |
| Protein | NP_004612, 5730102 |
| Product | short transient receptor potential channel 6 |
| RefSeq Status | REVIEWED |
| epopathway | EPO signaling pathway |
| nephrin_neph1_pathway | Nephrin/Neph1 signaling in the kidney podocyte |
| endothelinpathway | Endothelins |
Reactome
| REACT_162 | Elevation of cytosolic Ca2+ levels |
| REACT_18266 | Axon guidance |
| REACT_2202 | Effects of PIP2 hydrolysis |
| REACT_19184 | GPCR downstream signaling |
| REACT_20 | Formation of Platelet plug |
| REACT_22228 | Role of second messengers in netrin-1 signaling |
| REACT_798 | Platelet Activation |
| REACT_18283 | G alpha (q) signalling events |
| REACT_14797 | Signaling by GPCR |
| REACT_22237 | Netrin-1 signaling |
| REACT_23905 | Platelet calcium homeostasis |
| REACT_23876 | Platelet homeostasis |
| REACT_604 | Hemostasis |
| Homo sapiens (human) | TRPC6 | NP_004612.2 |
| Pan troglodytes (chimpanzee) | TRPC6 | XP_001150152.1 |
| Canis lupus familiaris (dog) | TRPC6 | XP_546553.2 |
| Bos taurus (cattle) | TRPC6 | XP_586071.3 |
| Mus musculus (house mouse) | Trpc6 | NP_038866.1 |
| Rattus norvegicus (Norway rat) | Trpc6 | NP_446011.1 |
| Gallus gallus (chicken) | TRPC6 | XP_417184.2 |
| Danio rerio (zebrafish) | trpc6 | NP_001025453.1 |
| Danio rerio (zebrafish) | LOC100333090 | XP_002665445.1 |
| Caenorhabditis elegans | trp-1 | NP_001040889.1 |
| ID | Name | Evidence |
| GO:0006812 | cation transport | TAS |
| GO:0007204 | elevation of cytosolic calcium ion concentration | IEA |
| GO:0007411 | axon guidance | TAS |
| GO:0007596 | blood coagulation | TAS |
| GO:0030168 | platelet activation | TAS |
| GO:0032236 | positive regulation of calcium ion transport via store-operated calcium channel activity | IDA |
| GO:0032414 | positive regulation of ion transmembrane transporter activity | IDA |
| GO:0055085 | transmembrane transport | IEA |
Component
| ID | Name | Evidence |
| GO:0005886 | plasma membrane | IDA |
| GO:0005886 | plasma membrane | TAS |
| GO:0016021 | integral to membrane | IEA |
Function
| ID | Name | Evidence |
| GO:0005515 | protein binding | IPI |
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