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Sequence in raw or FASTA format:


Blast Method:


TTR transthyretin [Homo sapiens (human)]

RefSeq Accession Definition Services Price Order
NM_000371 Homo sapiens transthyretin (TTR), mRNA. ORF Sequence $159.00
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Gene Symbol TTR
Entrez Gene ID 7276
Full Name transthyretin
Synonyms CTS, CTS1, HsT2651, PALB, TBPA
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc. [provided by RefSeq, Jan 2009].

MIM: 176300

Amyloidosis, hereditary, transthyretin-related, 105210 (3);

mRNA Protein Product Sequence Price Select
NM_000371, 221136767 NP_000362, 4507725 transthyretin precursor Full Length $272.02
ORF Sequence $159.00
Pathway Interaction Database
hnf3bpathwayFOXA2 and FOXA3 transcription factor networks
Homo sapiens (human)TTRNP_000362.1
Pan troglodytes (chimpanzee)TTRNP_001009137.1
Macaca mulatta (Rhesus monkey)TTRXP_001099005.1
Canis lupus familiaris (dog)TTRXP_003434968.1
Bos taurus (cattle)TTRNP_776392.1
Mus musculus (house mouse)TtrNP_038725.1
Rattus norvegicus (Norway rat)TtrNP_036813.1
Gallus gallus (chicken)TTRNP_990666.1
Danio rerio (zebrafish)ttrNP_001005598.2

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
carpal tunnel syndrome 1
thyroxine-binding prealbumin
prealbumin, amyloidosis type I


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