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Sequence in raw or FASTA format:


Blast Method:


TTR transthyretin [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000371 Homo sapiens transthyretin (TTR), mRNA. GenEZ ORF Cloning In-stock $248.00 $199.00 10

*Business Day

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Gene Symbol TTR
Entrez Gene ID 7276
Full Name transthyretin
Synonyms CTS, CTS1, HEL111, HsT2651, PALB, TBPA
General protein information
Preferred Names
carpal tunnel syndrome 1
thyroxine-binding prealbumin
prealbumin, amyloidosis type I
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc. [provided by RefSeq, Jan 2009].

MIM: 176300

Amyloidosis, hereditary, transthyretin-related, 105210 (3);

mRNA Protein Product Sequence Price Select
NM_000371, 221136767 NP_000362, 4507725 transthyretin precursor ORF Sequence $99.00
Pathway Interaction Database
hnf3bpathwayFOXA2 and FOXA3 transcription factor networks
REACT_24968Retinoid metabolism and transport
REACT_111102Signal Transduction
REACT_118779Extracellular matrix organization
REACT_163874Non-integrin membrane-ECM interactions
REACT_160102Diseases associated with visual transduction
REACT_160125Visual phototransduction
REACT_160130Retinoid cycle disease events
REACT_160156The canonical retinoid cycle in rods (twilight vision)
Homo sapiens (human)TTRNP_000362.1
Pan troglodytes (chimpanzee)TTRNP_001009137.1
Macaca mulatta (Rhesus monkey)TTRXP_001099005.1
Canis lupus familiaris (dog)TTRXP_537290.1
Bos taurus (cattle)TTRNP_776392.1
Mus musculus (house mouse)TtrNP_038725.1
Rattus norvegicus (Norway rat)TtrNP_036813.2
Gallus gallus (chicken)TTRNP_990666.1
Danio rerio (zebrafish)ttrNP_001005598.2
Xenopus (Silurana) tropicalis (western clawed frog)ttrNP_001096539.1
GO:0001523retinoid metabolic processTAS
GO:0007603phototransduction, visible lightTAS
GO:0030198extracellular matrix organizationTAS
GO:0042572retinol metabolic processIEA
GO:0005576extracellular regionNAS
GO:0005576extracellular regionTAS
GO:0005615extracellular spaceIDA
GO:0043234protein complexIEA
GO:0070062extracellular vesicular exosomeIDA
GO:0005179hormone activityIEA
GO:0005515protein bindingIPI
GO:0042562hormone bindingIEA
GO:0042802identical protein bindingIPI
GO:0046982protein heterodimerization activityIEA

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the TTR gene?

The TTR gene provides instructions for producing a protein called transthyretin. This protein transports vitamin A (retinol) and a hormone called thyroxine throughout the body. To transport thyroxine, four transthyretin proteins must be attached (bound) to each other to form a four-protein unit (tetramer). To transport retinol, transthyretin must form a tetramer and also bind to retinol binding protein. Transthyretin is produced primarily in the liver. A small amount of this protein is produced in an area of the brain called the choroid plexus and in the light-sensitive tissue that lines the back of the eye (the retina).


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