Search Tips

  • THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


TUBA4A tubulin, alpha 4a [Homo sapiens (human)]


RefSeq Accession Definition Sequence Price Select
NM_006000 Homo sapiens tubulin, alpha 4a (TUBA4A), mRNA. Full Length $439.06
ORF Sequence $390.63


Gene Symbol TUBA4A
Entrez Gene ID 7277
Full Name tubulin, alpha 4a
Synonyms FLJ30169, H2-ALPHA, TUBA1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2q35
Summary Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene encodes an alpha tubulin that is a highly conserved homolog of a rat testis-specific alpha tubulin. [provided by RefSeq].
Disorder

MIM: 191110
mRNA NM_006000, 17921988
Protein NP_005991, 17921989
Product tubulin alpha-4A chain
RefSeq Status REVIEWED
KEGG
hsa04540Gap junction
hsa05130Pathogenic Escherichia coli infection
hsa04145Phagosome
WikiPathways
WP69T Cell Receptor Signaling Pathway
Reactome
REACT_15451Loss of proteins required for interphase microtubule organization##from the centrosome
REACT_17004Chaperonin-mediated protein folding
REACT_604Hemostasis
REACT_16936Prefoldin mediated transfer of substrate to CCT/TriC
REACT_798Platelet Activation
REACT_15364Loss of Nlp from mitotic centrosomes
REACT_17029Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
REACT_21391Mitotic G2-G2/M phases
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_17015Metabolism of proteins
REACT_15479Centrosome maturation
REACT_16952Protein folding
REACT_16967Post-chaperonin tubulin folding pathway
REACT_20Formation of Platelet plug
REACT_16956Formation of tubulin folding intermediates by CCT/TriC
REACT_2203G2/M Transition
REACT_318Platelet degranulation
REACT_152Cell Cycle, Mitotic
REACT_15296Recruitment of mitotic centrosome proteins and complexes
Homo sapiens (human)TUBA4ANP_005991.1
Pan troglodytes (chimpanzee)TUBA4AXP_526036.2
Canis lupus familiaris (dog)TUBA4AXP_536077.2
Bos taurus (cattle)TUBA4ANP_001071626.1
Mus musculus (house mouse)Tuba4aNP_033473.1
Rattus norvegicus (Norway rat)Tuba4aNP_001007005.1
Gallus gallus (chicken)TUBA4AXP_416397.1
Danio rerio (zebrafish)tuba8l2NP_956985.1
Danio rerio (zebrafish)LOC100330913XP_002660384.1
Process
IDNameEvidence
GO:0000086G2/M transition of mitotic cell cycleTAS
GO:0000278mitotic cell cycleTAS
GO:0002576platelet degranulationTAS
GO:0006457protein foldingTAS
GO:0007018microtubule-based movementIEA
GO:0007596blood coagulationTAS
GO:0030168platelet activationTAS
GO:0044267cellular protein metabolic processTAS
GO:0051084'de novo' posttranslational protein foldingTAS
GO:0051258protein polymerizationIEA
Component
IDNameEvidence
GO:0005576extracellular regionEXP
GO:0005737cytoplasmIEA
GO:0005829cytosolEXP
GO:0005856cytoskeletonIEA
GO:0005874microtubuleIEA
Function
IDNameEvidence
GO:0000166nucleotide bindingIEA
GO:0003924GTPase activityIEA
GO:0005198structural molecule activityIEA
GO:0005515protein bindingIPI
GO:0005525GTP bindingIEA
GeneCards TUBA4A
UniProt P68366
MIM 191110
Ensembl ENSG00000127824
HGNC 12407
HPRD 01851

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.

Secured Online Quotation
Email: gene@genscript.com
Phone: 1-877-436-7274 (Toll-Free) 1-732-885-9188
Fax: 1-732-210-0262 1-732-885-5878