UBE2N ubiquitin-conjugating enzyme E2N [Homo sapiens (human)]

Gene Symbol	UBE2N
Entrez Gene ID	7334
Full Name	ubiquitin-conjugating enzyme E2N
Synonyms	MGC131857, MGC8489, UBC13, UbcH-ben
Gene Type	protein-coding
Organism	Homo sapiens (human)
Genome	Chromosome:12 Map Location:12q22
Summary	The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair. [provided by RefSeq].
Disorder	MIM: 603679

mRNA	NM_003348, 37577134
Protein	NP_003339, 4507793
Product	ubiquitin-conjugating enzyme E2 N
RefSeq Status	REVIEWED

KEGG

hsa04120

Ubiquitin mediated proteolysis

Pathway Interaction Database

il1pathway

IL1-mediated signaling events

Reactome

REACT_8005	Toll Like Receptor TLR1:TLR2 Cascade
REACT_9020	Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_6966	Toll Receptor Cascades
REACT_25120	TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
REACT_6894	Toll Like Receptor 4 (TLR4) Cascade
REACT_24918	IRAK1 recruits IKK comlex
REACT_6890	Activated TLR4 signalling
REACT_6788	MyD88:Mal cascade initiated on plasma membrane
REACT_12526	TCR signaling
REACT_9047	Toll Like Receptor 9 (TLR9) Cascade
REACT_8006	Toll Like Receptor TLR6:TLR2 Cascade
REACT_12555	Downstream TCR signaling
REACT_25222	MyD88 dependent cascade initiated on endosome
REACT_6900	Signaling in Immune system
REACT_22442	Interleukin-1 signaling
REACT_25354	IRAK1 recruits IKK comlex upon TLR7/8 or 9 stimulation
REACT_7980	Toll Like Receptor 2 Cascade
REACT_22232	Signaling by Interleukins
REACT_6802	Innate Immunity Signaling
REACT_25024	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation

Homo sapiens (human)	UBE2N	NP_003339.1
Pan troglodytes (chimpanzee)	UBE2N	XP_001139171.1
Canis lupus familiaris (dog)	UBE2N	XP_534272.1
Bos taurus (cattle)	UBE2N	NP_001069726.1
Mus musculus (house mouse)	Ube2n	NP_542127.1
Rattus norvegicus (Norway rat)	Ube2n	NP_446380.1
Gallus gallus (chicken)	UBE2N	NP_001012828.1
Danio rerio (zebrafish)	ube2nb	NP_956636.1
Danio rerio (zebrafish)	ube2na	NP_998651.1
Drosophila melanogaster (fruit fly)	ben	NP_001162752.1
Caenorhabditis elegans	ubc-13	NP_500272.2
Arabidopsis thaliana (thale cress)	UBC35	NP_849902.2

Process

ID	Name	Evidence
GO:0000724	double-strand break repair via homologous recombination	IMP
GO:0000729	DNA double-strand break processing	IMP
GO:0002224	toll-like receptor signaling pathway	TAS
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	EXP
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	TAS
GO:0006282	regulation of DNA repair	TAS
GO:0006301	postreplication repair	IMP
GO:0006464	protein modification process	TAS
GO:0006508	proteolysis	TAS
GO:0008063	Toll signaling pathway	TAS
GO:0016567	protein ubiquitination	IMP
GO:0016567	protein ubiquitination	TAS
GO:0016574	histone ubiquitination	IMP
GO:0031058	positive regulation of histone modification	IMP
GO:0033182	regulation of histone ubiquitination	IMP
GO:0034130	toll-like receptor 1 signaling pathway	TAS
GO:0034134	toll-like receptor 2 signaling pathway	TAS
GO:0034142	toll-like receptor 4 signaling pathway	TAS
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	IMP
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	TAS
GO:0045087	innate immune response	TAS
GO:0045739	positive regulation of DNA repair	IMP
GO:0050852	T cell receptor signaling pathway	IMP
GO:0050852	T cell receptor signaling pathway	TAS
GO:0051092	positive regulation of NF-kappaB transcription factor activity	IMP
GO:0051443	positive regulation of ubiquitin-protein ligase activity	IMP
GO:0070534	protein K63-linked ubiquitination	IDA

Component

Function

ID	Name	Evidence
GO:0000166	nucleotide binding	IEA
GO:0004842	ubiquitin-protein ligase activity	IDA
GO:0005515	protein binding	IPI
GO:0005524	ATP binding	IEA
GO:0016874	ligase activity	IEA
GO:0016881	acid-amino acid ligase activity	IEA
GO:0043130	ubiquitin binding	IDA

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.

RefSeq Accession	Definition	Sequence	Price	Select
NM_003348	Homo sapiens ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) (UBE2N), mRNA.	Full Length	$744.72
NM_003348		ORF Sequence	$159.00