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Sequence in raw or FASTA format:


Blast Method:


UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) [Homo sapiens (human)]

RefSeq Accession Definition Services Price Order
NM_004181 Homo sapiens ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) (UCHL1), mRNA. ORF Sequence $194.88
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Gene Symbol UCHL1
Entrez Gene ID 7345
Full Name ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
Synonyms PARK5, PGP 9.5, PGP9.5, PGP95, Uch-L1
Gene Type protein-coding
Organism Homo sapiens (human)



Summary The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009].

MIM: 191342

{Parkinson disease 5, susceptibility to}, 613643 (3); {Parkinson

mRNA Protein Product Sequence Price Select
NM_004181, 239835751 NP_004172, 21361091 ubiquitin carboxyl-terminal hydrolase isozyme L1 Full Length $330.89
ORF Sequence $194.88
hsa05012Parkinson's disease
Pathway Interaction Database
alphasynuclein_pathwayAlpha-synuclein signaling
WP183Proteasome Degradation
WP2371Parkinsons Disease Pathway
Homo sapiens (human)UCHL1NP_004172.2
Pan troglodytes (chimpanzee)UCHL1XP_517163.2
Macaca mulatta (Rhesus monkey)LOC701579XP_001097839.2
Canis lupus familiaris (dog)UCHL1XP_536245.3
Bos taurus (cattle)UCHL1NP_001039637.1
Mus musculus (house mouse)Uchl1NP_035800.2
Rattus norvegicus (Norway rat)Uchl1NP_058933.2
Gallus gallus (chicken)UCHL1NP_001073681.1
Danio rerio (zebrafish)uchl1NP_958885.1
GeneCards UCHL1
PDB 2LEN, 2ETL, 3IFW, 4DM9, 3IRT, 3KW5, 3KVF
UniProt P09936
MIM 191342
Ensembl ENSG00000154277
HGNC 12513
HPRD 01877

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase isozyme L1
ubiquitin carboxyl-terminal hydrolase isozyme L1
ubiquitin thioesterase L1
neuron cytoplasmic protein 9.5
ubiquitin C-terminal hydrolase


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