• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu19475 NM_004181 Homo sapiens ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) (UCHL1), mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu19475C NM_004181 Homo sapiens ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) (UCHL1), mRNA. Customized vector In-stock 5-7 $149.00

*Business Day

Related Services

Gene Symbol UCHL1
Entrez Gene ID 7345
Full Name ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
Synonyms HEL-117, NDGOA, PARK5, PGP 9.5, PGP9.5, PGP95, Uch-L1
General protein information
Preferred Names
ubiquitin carboxyl-terminal hydrolase isozyme L1
Names
ubiquitin carboxyl-terminal hydrolase isozyme L1
ubiquitin thioesterase L1
neuron cytoplasmic protein 9.5
ubiquitin C-terminal hydrolase
NP_004172.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4p14

Summary The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009].
Disorder

MIM: 191342

{Parkinson disease 5, susceptibility to}, 613643 (3); {Parkinson

mRNA Protein Product Sequence Price Select
NM_004181, 239835751 NP_004172, 21361091 ubiquitin carboxyl-terminal hydrolase isozyme L1 ORF Sequence $159.00
KEGG
hsa05012Parkinson's disease
WikiPathways
WP183Proteasome Degradation
WP2371Parkinsons Disease Pathway
Pathway Interaction Database
alphasynuclein_pathwayAlpha-synuclein signaling
Homo sapiens (human)UCHL1NP_004172.2
Pan troglodytes (chimpanzee)UCHL1XP_517163.2
Macaca mulatta (Rhesus monkey)LOC701579XP_001097839.2
Canis lupus familiaris (dog)UCHL1XP_536245.3
Bos taurus (cattle)UCHL1NP_001039637.1
Mus musculus (house mouse)Uchl1NP_035800.2
Rattus norvegicus (Norway rat)Uchl1NP_058933.2
Gallus gallus (chicken)UCHL1NP_001073681.1
Danio rerio (zebrafish)uchl1NP_958885.1
Xenopus (Silurana) tropicalis (western clawed frog)uchl1NP_001011321.1
Process
IDNameEvidence
GO:0002931response to ischemiaIEA
GO:0006511ubiquitin-dependent protein catabolic processIEA
GO:0007412axon target recognitionIEA
GO:0007628adult walking behaviorIEA
GO:0008219cell deathIEA
GO:0008283cell proliferationIEA
GO:0016579protein deubiquitinationIDA
GO:0019233sensory perception of painIEA
GO:0019896axon transport of mitochondrionIEA
GO:0042755eating behaviorIEA
GO:0043407negative regulation of MAP kinase activityIDA
GO:0048747muscle fiber developmentIEA
GO:0050905neuromuscular processIEA
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005730nucleolusIDA
GO:0005737cytoplasmIDA
GO:0005737cytoplasmISS
GO:0005737cytoplasmTAS
GO:0005789endoplasmic reticulum membraneIEA
GO:0005829cytosolIEA
GO:0005886plasma membraneIDA
GO:0030424axonIEA
GO:0043025neuronal cell bodyIEA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0004197cysteine-type endopeptidase activityIDA
GO:0004221ubiquitin thiolesterase activityTAS
GO:0004843ubiquitin-specific protease activityIEA
GO:0005515protein bindingIPI
GO:0008242omega peptidase activityIDA
GO:0016874ligase activityIEA
GO:0031694alpha-2A adrenergic receptor bindingIPI
GO:0043130ubiquitin bindingIDA
GeneCards UCHL1
PDB 2LEN, 2ETL, 3IFW, 4DM9, 3IRT, 3KW5, 3KVF
UniProt V9HW74, P09936
Vega OTTHUMG00000099377
MIM 191342
Ensembl ENSG00000154277
HGNC 12513
HPRD 01877

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.