• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


UMOD uromodulin [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_001008389 Homo sapiens uromodulin (UMOD), transcript variant 2, mRNA. ORF Sequence $557.67
Peptide Services
Antibody Services
Protein Services
NM_003361 Homo sapiens uromodulin (UMOD), transcript variant 1, mRNA. ORF Sequence $557.67
Peptide Services
Antibody Services
Protein Services


Gene Symbol UMOD
Entrez Gene ID 7369
Full Name uromodulin
Synonyms ADMCKD2, FJHN, HNFJ, HNFJ1, MCKD2, THGP, THP
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

16

16p12.3

Summary This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. [provided by RefSeq, Jul 2008].
Disorder

MIM: 191845

Hyperuricemic nephropathy, familial juvenile 1, 162000 (3);

mRNA Protein Product Sequence Price Select
NM_001008389, 56550048 NP_001008390, 56550049 uromodulin precursor Full Length $656.56
ORF Sequence $557.67
NM_003361, 59850811 NP_003352, 59850812 uromodulin precursor Full Length $674.83
ORF Sequence $557.67
Homo sapiens (human)UMODNP_003352.2
Macaca mulatta (Rhesus monkey)UMODXP_001086040.2
Canis lupus familiaris (dog)UMODNP_001003003.1
Bos taurus (cattle)UMODNP_776638.1
Mus musculus (house mouse)UmodNP_033496.1
Rattus norvegicus (Norway rat)UmodNP_058778.1
GeneCards UMOD
UniProt P07911
MIM 191845
Ensembl ENSG00000169344
HGNC 12559
HPRD 11771

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
uromodulin
Names
uromodulin
uromucoid
Tamm-Horsfall urinary glycoprotein

Interactant

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.

Secured Online Quotation
Email: gene@genscript.com
Phone: 1-877-436-7274 (Toll-Free) 1-732-885-9188
Fax: 1-732-210-0262 1-732-885-5878