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VCL vinculin [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_003373 Homo sapiens vinculin (VCL), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
NM_014000 Homo sapiens vinculin (VCL), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $1699.00 25

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Gene Symbol VCL
Entrez Gene ID 7414
Full Name vinculin
Synonyms CMD1W, CMH15, MVCL
Gene Type protein-coding
Organism Homo sapiens (human)



Summary Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008].

MIM: 193065

Cardiomyopathy, dilated, 1W, 611407 (3); Cardiomyopathy, familial

mRNA Protein Product Sequence Price Select
NM_003373, 50593538 NP_003364, 4507877 vinculin isoform VCL ORF Sequence $1500.00
NM_014000, 50593530 NP_054706, 7669550 vinculin isoform meta-VCL ORF Sequence $1500.00
hsa05100Bacterial invasion of epithelial cells
hsa04520Adherens junction
hsa04810Regulation of actin cytoskeleton
hsa04670Leukocyte transendothelial migration
hsa04510Focal adhesion
WP185Integrin-mediated cell adhesion
WP306Focal Adhesion
WP51Regulation of Actin Cytoskeleton
WP286IL-3 Signaling Pathway
Pathway Interaction Database
fak_pathwaySignaling events mediated by focal adhesion kinase
rhoa_pathwayRhoA signaling pathway
ecadherin_stabilization_pathwayStabilization and expansion of the E-cadherin adherens junction
vegfr1_2_pathwaySignaling events mediated by VEGFR1 and VEGFR2
avb3_integrin_pathwayIntegrins in angiogenesis
REACT_318Platelet degranulation
REACT_20558Smooth Muscle Contraction
REACT_798Platelet activation, signaling and aggregation
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_17044Muscle contraction
Homo sapiens (human)VCLNP_054706.1
Pan troglodytes (chimpanzee)VCLXP_001147346.1
Macaca mulatta (Rhesus monkey)VCLXP_001118118.1
Canis lupus familiaris (dog)VCLXP_536395.3
Bos taurus (cattle)VCLNP_001178299.1
Mus musculus (house mouse)VclNP_033528.3
Rattus norvegicus (Norway rat)VclNP_001100718.1
Gallus gallus (chicken)VCLNP_990772.1
Danio rerio (zebrafish)vclNP_001122153.1
GeneCards VCL
PDB 3MYI, 2GWW, 3TJ6, 3RF3, 3H2V, 3H2U, 1RKE, 1YDI, 3VF0, 4DJ9, 1RKC, 2IBF, 4EHP, 2HSQ, 1TR2, 3TJ5, 1SYQ, 3S90
UniProt P18206, B3KXA2
MIM 193065
Ensembl ENSG00000035403
HGNC 12665
HPRD 01900

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names


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