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VCL vinculin [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu25331 NM_003373 Homo sapiens vinculin (VCL), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 25 $1699.00
OHu25616 NM_014000 Homo sapiens vinculin (VCL), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 25 $1699.00
OHu44532 XM_005270142 PREDICTED: Homo sapiens vinculin (VCL), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 25 $1699.00
OHu44533 XM_005270143 PREDICTED: Homo sapiens vinculin (VCL), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 25 $1699.00
OHu25331C NM_003373 Homo sapiens vinculin (VCL), transcript variant 2, mRNA. Customized vector On-demand 25 $1699.00
OHu25616C NM_014000 Homo sapiens vinculin (VCL), transcript variant 1, mRNA. Customized vector On-demand 25 $1699.00
OHu44532C XM_005270142 PREDICTED: Homo sapiens vinculin (VCL), transcript variant X1, mRNA. Customized vector On-demand 25 $1699.00
OHu44533C XM_005270143 PREDICTED: Homo sapiens vinculin (VCL), transcript variant X2, mRNA. Customized vector On-demand 25 $1699.00

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Gene Symbol VCL
Entrez Gene ID 7414
Full Name vinculin
Synonyms CMD1W, CMH15, HEL114, MV, MVCL
General protein information
Preferred Names
vinculin
Names
vinculin
metavinculin
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

10

10q22.2

Summary Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008].
Disorder

MIM: 193065

Cardiomyopathy, dilated, 1W, 611407 (3); Cardiomyopathy, familial

mRNA Protein Product Sequence Price Select
NM_003373, 50593538 NP_003364, 4507877 vinculin isoform VCL ORF Sequence $1500.00
NM_014000, 50593530 NP_054706, 7669550 vinculin isoform meta-VCL ORF Sequence $1500.00
XM_005270142, 530394327 XP_005270199, 530394328 vinculin isoform X1 ORF Sequence $1500.00
XM_005270143, 530394329 XP_005270200, 530394330 vinculin isoform X2 ORF Sequence $1500.00
KEGG
hsa04520Adherens junction
hsa04510Focal adhesion
hsa04810Regulation of actin cytoskeleton
hsa04670Leukocyte transendothelial migration
hsa05131Shigellosis
hsa05146Amoebiasis
hsa05100Bacterial invasion of epithelial cells
WikiPathways
WP185Integrin-mediated cell adhesion
WP51Regulation of Actin Cytoskeleton
WP286IL-3 Signaling Pathway
Pathway Interaction Database
vegfr1_2_pathwaySignaling events mediated by VEGFR1 and VEGFR2
ecadherin_stabilization_pathwayStabilization and expansion of the E-cadherin adherens junction
avb3_integrin_pathwayIntegrins in angiogenesis
rhoa_pathwayRhoA signaling pathway
fak_pathwaySignaling events mediated by focal adhesion kinase
Reactome
REACT_798Platelet activation, signaling and aggregation
REACT_604Hemostasis
REACT_318Platelet degranulation
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_17044Muscle contraction
REACT_20558Smooth Muscle Contraction
Homo sapiens (human)VCLNP_054706.1
Pan troglodytes (chimpanzee)VCLXP_507854.2
Macaca mulatta (Rhesus monkey)VCLXP_001118118.1
Canis lupus familiaris (dog)VCLXP_536395.3
Bos taurus (cattle)VCLNP_001178299.1
Mus musculus (house mouse)VclNP_033528.3
Rattus norvegicus (Norway rat)VclNP_001100718.1
Gallus gallus (chicken)VCLNP_990772.1
Danio rerio (zebrafish)vclaNP_001122153.1
Xenopus (Silurana) tropicalis (western clawed frog)vclNP_001090722.1
Process
IDNameEvidence
GO:0002009morphogenesis of an epitheliumIMP
GO:0002576platelet degranulationTAS
GO:0006928cellular component movementTAS
GO:0006936muscle contractionTAS
GO:0007155cell adhesionTAS
GO:0007160cell-matrix adhesionTAS
GO:0007596blood coagulationTAS
GO:0030032lamellipodium assemblyISS
GO:0030168platelet activationTAS
GO:0030336negative regulation of cell migrationTAS
GO:0034333adherens junction assemblyIMP
GO:0034394protein localization to cell surfaceIMP
GO:0043297apical junction assemblyIMP
GO:0090136epithelial cell-cell adhesionIMP
Component
IDNameEvidence
GO:0005576extracellular regionTAS
GO:0005829cytosolTAS
GO:0005856cytoskeletonTAS
GO:0005886plasma membraneIEA
GO:0005911cell-cell junctionISS
GO:0005912adherens junctionISS
GO:0005913cell-cell adherens junctionIDA
GO:0005916fascia adherensIEA
GO:0005925focal adhesionIDA
GO:0005925focal adhesionISS
GO:0015629actin cytoskeletonIEA
GO:0030055cell-substrate junctionNAS
GO:0043034costamereIDA
GO:0043034costamereISS
GO:0043234protein complexIDA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0002162dystroglycan bindingIPI
GO:0003779actin bindingIDA
GO:0003779actin bindingIDA
GO:0005198structural molecule activityIEA
GO:0005515protein bindingIPI
GO:0008013beta-catenin bindingISS
GO:0045294alpha-catenin bindingIPI
GO:0045296cadherin bindingISS
GeneCards VCL
UniProt V9HWK2, P18206, B3KXA2
Vega OTTHUMG00000018498
MIM 193065
Ensembl ENSG00000035403
HGNC 12665
HPRD 01900

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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