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VLDLR very low density lipoprotein receptor [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001018056 Homo sapiens very low density lipoprotein receptor (VLDLR), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $899.00 20
NM_003383 Homo sapiens very low density lipoprotein receptor (VLDLR), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_006716864 PREDICTED: Homo sapiens very low density lipoprotein receptor (VLDLR), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_006716865 PREDICTED: Homo sapiens very low density lipoprotein receptor (VLDLR), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $899.00 20

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Related Services

Gene Symbol VLDLR
Entrez Gene ID 7436
Full Name very low density lipoprotein receptor
Synonyms CARMQ1, CHRMQ1, VLDLRCH
General protein information
Preferred Names
very low-density lipoprotein receptor
Names
very low-density lipoprotein receptor
VLDL-R
VLDL receptor
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

9

9p24

Summary The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. This gene encodes a lipoprotein receptor that is a member of the LDLR family and plays important roles in VLDL-triglyceride metabolism and the reelin signaling pathway. Mutations in this gene cause VLDLR-associated cerebellar hypoplasia. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene. [provided by RefSeq, Aug 2009].
Disorder

MIM: 192977

Cerebellar hypoplasia and mental retardation with or without

mRNA Protein Product Sequence Price Select
NM_001018056, 65301163 NP_001018066, 65301164 very low-density lipoprotein receptor isoform b precursor ORF Sequence $750.00
NM_003383, 65301166 NP_003374, 65301167 very low-density lipoprotein receptor isoform a precursor ORF Sequence $750.00
XM_006716864, 578816710 XP_006716927, 578816711 very low-density lipoprotein receptor isoform X1 ORF Sequence $750.00
XM_006716865, 578816712 XP_006716928, 578816713 very low-density lipoprotein receptor isoform X2 ORF Sequence $750.00
Pathway Interaction Database
reelinpathwayReelin signaling pathway
lis1pathwayLissencephaly gene (LIS1) in neuronal migration and development
Homo sapiens (human)VLDLRNP_003374.3
Pan troglodytes (chimpanzee)VLDLRXP_520460.3
Macaca mulatta (Rhesus monkey)VLDLRNP_001028079.1
Canis lupus familiaris (dog)VLDLRXP_533538.2
Bos taurus (cattle)VLDLRNP_776914.1
Mus musculus (house mouse)VldlrNP_038731.2
Rattus norvegicus (Norway rat)VldlrNP_037287.2
Gallus gallus (chicken)VLDLRNP_990560.1
Danio rerio (zebrafish)vldlrNP_957217.2
Drosophila melanogaster (fruit fly)LpR2NP_001097928.1
Drosophila melanogaster (fruit fly)LpR1NP_001262974.1
Caenorhabditis elegansT13C2.6NP_872023.2
Xenopus (Silurana) tropicalis (western clawed frog)vldlrXP_002934223.1
Process
IDNameEvidence
GO:0000122negative regulation of transcription from RNA polymerase II promoterISS
GO:0006869lipid transportIEA
GO:0006898receptor-mediated endocytosisIDA
GO:0007165signal transductionTAS
GO:0007399nervous system developmentTAS
GO:0007613memoryTAS
GO:0008203cholesterol metabolic processIEA
GO:0021517ventral spinal cord developmentIEA
GO:0034436glycoprotein transportIDA
GO:0034447very-low-density lipoprotein particle clearanceIDA
GO:0038026reelin-mediated signaling pathwayISS
GO:0045860positive regulation of protein kinase activityIEA
GO:1900006positive regulation of dendrite developmentISS
Component
IDNameEvidence
GO:0005886plasma membraneTAS
GO:0005905coated pitIEA
GO:0016020membraneIDA
GO:0016021integral component of membraneIEA
GO:0034361very-low-density lipoprotein particleIEA
GO:0043235receptor complexIDA
Function
IDNameEvidence
GO:0001948glycoprotein bindingIPI
GO:0005041low-density lipoprotein receptor activityTAS
GO:0005509calcium ion bindingIEA
GO:0005515protein bindingIPI
GO:0030229very-low-density lipoprotein particle receptor activityIDA
GO:0034185apolipoprotein bindingIDA
GO:0034185apolipoprotein bindingISS
GO:0034189very-low-density lipoprotein particle bindingIDA
GO:0034437glycoprotein transporter activityIDA
GO:0038025reelin receptor activityISS
GO:0048306calcium-dependent protein bindingIPI
GeneCards VLDLR
UniProt P98155, Q5VVF5
Vega OTTHUMG00000019447
MIM 192977
Ensembl ENSG00000147852
HGNC 12698
HPRD 01895

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the VLDLR gene?

The VLDLR gene provides instructions for making a protein called a very low density lipoprotein (VLDL) receptor. This protein is active in many different organs and tissues, including the heart, muscles used for movement (skeletal muscles), fatty (adipose) tissue, and the kidneys. The VLDL receptor appears to play a particularly important role in the developing brain.

The VLDL receptor works together with a protein called reelin. Reelin fits into the VLDL receptor like a key in a lock, which triggers a series of chemical reactions within the cell. During early brain development, the reelin signaling pathway helps to guide the movement of immature nerve cells (neuroblasts) to their appropriate locations in the brain.

Interactant

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