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VWF von Willebrand factor [Homo sapiens (human)]

Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu26652D NM_000552 Homo sapiens von Willebrand factor (VWF), mRNA. pcDNA3.1-C-(k)DYK In-stock 24 Starting from $99
OHu26652C NM_000552 Homo sapiens von Willebrand factor (VWF), mRNA. Customized vector In-stock 24 Starting from $99

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Gene Symbol VWF
Entrez Gene ID 7450
Full Name von Willebrand factor
Synonyms F8VWF, VWD
General protein information
Preferred Names
von Willebrand factor
von Willebrand factor
coagulation factor VIII VWF
Gene Type protein-coding
Organism Homo sapiens (human)



Summary The glycoprotein encoded by this gene functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system. It is crucial to the hemostasis process. Mutations in this gene or deficiencies in this protein result in von Willebrand's disease. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008].

MIM: 613160

von Willebrand disease, type 2A, 2B, 2M, and 2N, 613554 (3); von

mRNA Protein Product Sequence Price Select
NM_000552, 89191867 NP_000543, 89191868 von Willebrand factor preproprotein ORF Sequence $2199.00
hsa04510Focal adhesion
hsa04512ECM-receptor interaction
hsa04610Complement and coagulation cascades
hsa04151PI3K-Akt signaling pathway
hsa04611Platelet activation
WP272Blood Clotting Cascade
REACT_798Platelet activation, signaling and aggregation
REACT_326Intrinsic Pathway
REACT_318Platelet degranulation
REACT_15443GRB2:SOS provides linkage to MAPK signaling for Integrins
REACT_2051Formation of Fibrin Clot (Clotting Cascade)
REACT_278Platelet Aggregation (Plug Formation)
REACT_15523Integrin alphaIIb beta3 signaling
REACT_15381p130Cas linkage to MAPK signaling for integrins
REACT_1230Platelet Adhesion to exposed collagen
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_23847GP1b-IX-V activation signalling
REACT_111102Signal Transduction
Homo sapiens (human)VWFNP_000543.2
Pan troglodytes (chimpanzee)VWFXP_001160508.1
Macaca mulatta (Rhesus monkey)VWFXP_002808020.1
Canis lupus familiaris (dog)VWFNP_001002932.1
Bos taurus (cattle)VWFNP_001192237.1
Mus musculus (house mouse)VwfNP_035838.3
Rattus norvegicus (Norway rat)VwfNP_446341.1
Gallus gallus (chicken)VWFXP_417223.3
Danio rerio (zebrafish)vwfXP_002665356.3
Xenopus (Silurana) tropicalis (western clawed frog)vwfNP_001243217.1
GO:0001889liver developmentIEA
GO:0001890placenta developmentIEA
GO:0002576platelet degranulationTAS
GO:0007155cell adhesionIDA
GO:0007596blood coagulationIMP
GO:0007596blood coagulationTAS
GO:0007597blood coagulation, intrinsic pathwayTAS
GO:0009611response to woundingTAS
GO:0030168platelet activationIDA
GO:0030168platelet activationNAS
GO:0030168platelet activationTAS
GO:0030198extracellular matrix organizationTAS
GO:0031589cell-substrate adhesionIDA
GO:0051260protein homooligomerizationIDA
GO:0005576extracellular regionIDA
GO:0005576extracellular regionNAS
GO:0005576extracellular regionTAS
GO:0005578proteinaceous extracellular matrixIEA
GO:0005783endoplasmic reticulumIDA
GO:0009897external side of plasma membraneIEA
GO:0031012extracellular matrixIDA
GO:0031091platelet alpha granuleNAS
GO:0031093platelet alpha granule lumenTAS
GO:0033093Weibel-Palade bodyIDA
GO:0070062extracellular vesicular exosomeIDA
GO:0001948glycoprotein bindingIDA
GO:0002020protease bindingIDA
GO:0002020protease bindingIPI
GO:0005178integrin bindingIPI
GO:0005515protein bindingIPI
GO:0005518collagen bindingIDA
GO:0019865immunoglobulin bindingIDA
GO:0042802identical protein bindingIPI
GO:0042803protein homodimerization activityIDA
GO:0047485protein N-terminus bindingIPI
GO:0051087chaperone bindingIDA
GeneCards VWF
PDB 1UEX, 1AUQ, 1OAK, 3HXQ, 2ADF, 3PPW, 4NT5, 1IJB, 1U0N, 4C2B, 4C29, 3PPV, 1FNS, 3PPX, 4C2A, 1IJK, 3GXB, 3ZQK, 3PPY, 2MHQ, 1SQ0, 1FE8, 1ATZ, 1AO3, 2MHP, 4DMU, 3HXO, 1M10
UniProt P04275
Vega OTTHUMG00000168265
MIM 613160
Ensembl ENSG00000110799
HGNC 12726
HPRD 01906

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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