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VWF von Willebrand factor [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000552 Homo sapiens von Willebrand factor (VWF), mRNA. GenEZ ORF Cloning In-stock $2448.00 $2399.00 24

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Gene Symbol VWF
Entrez Gene ID 7450
Full Name von Willebrand factor
Synonyms F8VWF, VWD
Gene Type protein-coding
Organism Homo sapiens (human)



Summary The glycoprotein encoded by this gene functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system. It is crucial to the hemostasis process. Mutations in this gene or deficiencies in this protein result in von Willebrand's disease. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008].

MIM: 613160

von Willebrand disease, type 2A, 2B, 2M, and 2N, 613554 (3); von

mRNA Protein Product Sequence Price Select
NM_000552, 89191867 NP_000543, 89191868 von Willebrand factor preproprotein ORF Sequence $2199.00
hsa04512ECM-receptor interaction
hsa04510Focal adhesion
hsa04610Complement and coagulation cascades
hsa04151PI3K-Akt signaling pathway
WP272Blood Clotting Cascade
WP558Complement and Coagulation Cascades
WP306Focal Adhesion
REACT_111102Signal Transduction
REACT_278Platelet Aggregation (Plug Formation)
REACT_15381p130Cas linkage to MAPK signaling for integrins
REACT_1230Platelet Adhesion to exposed collagen
REACT_15443GRB2:SOS provides linkage to MAPK signaling for Intergrins
REACT_13552Integrin cell surface interactions
REACT_15523Integrin alphaIIb beta3 signaling
REACT_23847GP1b-IX-V activation signalling
REACT_798Platelet activation, signaling and aggregation
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_2051Formation of Fibrin Clot (Clotting Cascade)
REACT_318Platelet degranulation
REACT_326Intrinsic Pathway
Homo sapiens (human)VWFNP_000543.2
Pan troglodytes (chimpanzee)VWFXP_001160508.1
Macaca mulatta (Rhesus monkey)VWFXP_002808020.1
Canis lupus familiaris (dog)VWFNP_001002932.1
Bos taurus (cattle)VWFNP_001192237.1
Mus musculus (house mouse)VwfNP_035838.3
Rattus norvegicus (Norway rat)VwfXP_342760.4
Gallus gallus (chicken)VWFXP_417223.3
Danio rerio (zebrafish)vwfXP_002665356.2
GeneCards VWF
PDB 1UEX, 1AUQ, 1OAK, 3HXQ, 2ADF, 3PPW, 1IJB, 1U0N, 3PPV, 1FNS, 3PPX, 1IJK, 3GXB, 3ZQK, 3PPY, 1SQ0, 1FE8, 1ATZ, 1AO3, 4DMU, 3HXO, 1M10
UniProt P04275
MIM 613160
Ensembl ENSG00000110799
HGNC 12726
HPRD 01906

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
von Willebrand factor
von Willebrand factor
coagulation factor VIII VWF


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