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WRN Werner syndrome, RecQ helicase-like [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000553 Homo sapiens Werner syndrome, RecQ helicase-like (WRN), mRNA. GenEZ ORF Cloning On-demand TBD TBD

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Gene Symbol WRN
Entrez Gene ID 7486
Full Name Werner syndrome, RecQ helicase-like
Synonyms DKFZp686C2056, RECQ3, RECQL2, RECQL3
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

8

8p12

Summary This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging. [provided by RefSeq, Jul 2008].
Disorder

MIM: 604611

Werner syndrome, 277700 (3)

mRNA Protein Product Sequence Price Select
NM_000553, 182507163 NP_000544, 110735439 Werner syndrome ATP-dependent helicase ORF Sequence $1500.00
WikiPathways
WP2377Integrated Pancreatic Cancer Pathway
WP2256Integrated Pancreatic Cancer Pathway
Pathway Interaction Database
telomerasepathwayRegulation of Telomerase
Homo sapiens (human)WRNNP_000544.2
Pan troglodytes (chimpanzee)WRNXP_528104.2
Macaca mulatta (Rhesus monkey)WRNXP_001085031.1
Canis lupus familiaris (dog)WRNXP_539984.3
Bos taurus (cattle)WRNNP_001137329.2
Mus musculus (house mouse)WrnNP_001116294.1
Rattus norvegicus (Norway rat)RGD1564788XP_002728460.1
Gallus gallus (chicken)WRNXP_001235033.2
Danio rerio (zebrafish)LOC569495XP_697980.4
Caenorhabditis eleganswrn-1NP_495324.2
GeneCards WRN
PDB 2FBY, 2FBX, 2AXL, 2E1E, 3AAF, 2FBT, 2FC0, 2FBV, 2E1F, 2DGZ
UniProt Q14191, Q59F09
MIM 604611
Ensembl ENSG00000165392
HGNC 12791
HPRD 05212

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
Werner syndrome ATP-dependent helicase
Names
Werner syndrome ATP-dependent helicase
exonuclease WRN
recQ protein-like 2
DNA helicase, RecQ-like type 3
NP_000544.2

Interactant



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