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WRN Werner syndrome, RecQ helicase-like [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000553 Homo sapiens Werner syndrome, RecQ helicase-like (WRN), mRNA. GenEZ ORF Cloning On-demand TBD TBD

*Business Day

Related Services

Gene Symbol WRN
Entrez Gene ID 7486
Full Name Werner syndrome, RecQ helicase-like
Synonyms RECQ3, RECQL2, RECQL3
General protein information
Preferred Names
Werner syndrome ATP-dependent helicase
Names
Werner syndrome ATP-dependent helicase
exonuclease WRN
recQ protein-like 2
DNA helicase, RecQ-like type 3
NP_000544.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

8

8p12

Summary This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging. [provided by RefSeq, Jul 2008].
Disorder

MIM: 604611

Werner syndrome, 277700 (3)

mRNA Protein Product Sequence Price Select
NM_000553, 182507163 NP_000544, 110735439 Werner syndrome ATP-dependent helicase ORF Sequence $1500.00
WikiPathways
WP2377Integrated Pancreatic Cancer Pathway
Pathway Interaction Database
telomerasepathwayRegulation of Telomerase
Homo sapiens (human)WRNNP_000544.2
Pan troglodytes (chimpanzee)WRNXP_528104.2
Macaca mulatta (Rhesus monkey)WRNXP_001085031.1
Canis lupus familiaris (dog)WRNXP_539984.4
Bos taurus (cattle)WRNNP_001137329.2
Mus musculus (house mouse)WrnNP_035851.3
Rattus norvegicus (Norway rat)RGD1564788XP_006253317.1
Gallus gallus (chicken)WRNXP_001235033.2
Danio rerio (zebrafish)wrnXP_697980.5
Caenorhabditis eleganswrn-1NP_495324.2
Xenopus (Silurana) tropicalis (western clawed frog)wrnXP_002939304.1
Process
IDNameEvidence
GO:0000723telomere maintenanceIMP
GO:0000731DNA synthesis involved in DNA repairIDA
GO:0001302replicative cell agingIEA
GO:0006200ATP catabolic processIDA
GO:0006200ATP catabolic processIEA
GO:0006259DNA metabolic processIDA
GO:0006260DNA replicationIMP
GO:0006284base-excision repairIDA
GO:0006302double-strand break repairIMP
GO:0006310DNA recombinationIEA
GO:0006974cellular response to DNA damage stimulusIDA
GO:0006979response to oxidative stressIDA
GO:0007568agingNAS
GO:0007569cell agingIMP
GO:0009267cellular response to starvationIDA
GO:0010225response to UV-CIDA
GO:0010259multicellular organismal agingIMP
GO:0031297replication fork processingIDA
GO:0031297replication fork processingIMP
GO:0032066nucleolus to nucleoplasm transportIDA
GO:0032508DNA duplex unwindingIDA
GO:0032508DNA duplex unwindingIEA
GO:0032508DNA duplex unwindingIMP
GO:0040009regulation of growth rateIEA
GO:0042981regulation of apoptotic processIGI
GO:0051345positive regulation of hydrolase activityIDA
GO:0071480cellular response to gamma radiationIDA
GO:0090305nucleic acid phosphodiester bond hydrolysisIDA
GO:0090305nucleic acid phosphodiester bond hydrolysisIEA
Component
IDNameEvidence
GO:0005654nucleoplasmIDA
GO:0005730nucleolusIDA
GO:0005813centrosomeIDA
GO:0032389MutLalpha complexIDA
Function
IDNameEvidence
GO:0000287magnesium ion bindingIDA
GO:0000403Y-form DNA bindingIDA
GO:0000405bubble DNA bindingIDA
GO:0003677DNA bindingIDA
GO:0003678DNA helicase activityIDA
GO:0003678DNA helicase activityIMP
GO:0004003ATP-dependent DNA helicase activityIDA
GO:0004386helicase activityIDA
GO:0004527exonuclease activityIDA
GO:0005515protein bindingIPI
GO:0005524ATP bindingIEA
GO:00084083'-5' exonuclease activityIDA
GO:0009378four-way junction helicase activityIDA
GO:0016887ATPase activityIDA
GO:0030145manganese ion bindingIDA
GO:0032403protein complex bindingIDA
GO:0042803protein homodimerization activityIDA
GO:00431383'-5' DNA helicase activityIDA
GO:0043140ATP-dependent 3'-5' DNA helicase activityIEA
GO:0051880G-quadruplex DNA bindingIDA
GeneCards WRN
PDB 2FBY, 2FBX, 2AXL, 2E1E, 3AAF, 2FBT, 2FC0, 2FBV, 2E1F, 2DGZ
UniProt Q14191, Q59F09
Vega OTTHUMG00000163894
MIM 604611
Ensembl ENSG00000165392
HGNC 12791
HPRD 05212

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the WRN gene?

The WRN gene provides instructions for producing the Werner protein, which plays a critical role in repairing damaged DNA. The Werner protein functions as a type of enzyme called a helicase. Helicase enzymes generally unwind and separate double-stranded DNA. The Werner protein also functions as an enzyme called an exonuclease. Exonucleases trim the broken ends of damaged DNA by removing DNA building blocks (nucleotides). Research suggests that the Werner protein first unwinds the DNA and then removes abnormal DNA structures that have been accidentally generated.

Overall, the Werner protein helps maintain the structure and integrity of a person's DNA. This protein plays an important role in copying (replicating) DNA before cell division and transferring the information in genes to the cell machinery that makes proteins (transcription). Additionally, recent studies suggest that the Werner protein may be particularly important for maintaining DNA at the ends of chromosomes (telomeres).

Interactant

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