Sequence in raw or FASTA format:

WRN Werner syndrome, RecQ helicase-like [Homo sapiens (human)]

Gene Symbol	WRN
Entrez Gene ID	7486
Full Name	Werner syndrome, RecQ helicase-like
Synonyms	DKFZp686C2056, RECQ3, RECQL2, RECQL3
Gene Type	protein-coding
Organism	Homo sapiens (human)
Genome	Chromosome:8 Map Location:8p12
Summary	This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging. [provided by RefSeq].
Disorder	MIM: 604611 Werner syndrome, 277700 (3)

mRNA	NM_000553, 182507163
Protein	NP_000544, 110735439
Product	Werner syndrome ATP-dependent helicase
RefSeq Status	REVIEWED

Pathway Interaction Database

telomerasepathway

Regulation of Telomerase

Process

ID	Name	Evidence
GO:0000723	telomere maintenance	IMP
GO:0000731	DNA synthesis involved in DNA repair	IDA
GO:0001302	replicative cell aging	IEA
GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	IEA
GO:0006200	ATP catabolic process	IDA
GO:0006259	DNA metabolic process	IDA
GO:0006260	DNA replication	IMP
GO:0006284	base-excision repair	IDA
GO:0006310	DNA recombination	IEA
GO:0006974	response to DNA damage stimulus	IDA
GO:0006979	response to oxidative stress	IDA
GO:0007568	aging	NAS
GO:0007569	cell aging	IMP
GO:0009267	cellular response to starvation	IDA
GO:0010225	response to UV-C	IDA
GO:0010259	multicellular organismal aging	IMP
GO:0031297	replication fork processing	IDA
GO:0031297	replication fork processing	IMP
GO:0032066	nucleolus to nucleoplasm transport	IDA
GO:0040009	regulation of growth rate	IEA
GO:0042981	regulation of apoptosis	IGI
GO:0044237	cellular metabolic process	IEA
GO:0051345	positive regulation of hydrolase activity	IDA

Component

Function

ID	Name	Evidence
GO:0000166	nucleotide binding	IEA
GO:0000287	magnesium ion binding	IDA
GO:0000403	Y-form DNA binding	IDA
GO:0000405	bubble DNA binding	IDA
GO:0003677	DNA binding	IDA
GO:0003678	DNA helicase activity	IDA
GO:0003678	DNA helicase activity	IMP
GO:0004003	ATP-dependent DNA helicase activity	IDA
GO:0004386	helicase activity	IDA
GO:0004527	exonuclease activity	IDA
GO:0005515	protein binding	IPI
GO:0005524	ATP binding	IEA
GO:0008408	3'-5' exonuclease activity	IDA
GO:0009378	four-way junction helicase activity	IDA
GO:0016887	ATPase activity	IDA
GO:0030145	manganese ion binding	IDA
GO:0032403	protein complex binding	IDA
GO:0042803	protein homodimerization activity	IDA
GO:0043138	3'-5' DNA helicase activity	IDA
GO:0043140	ATP-dependent 3'-5' DNA helicase activity	IEA
GO:0051880	G-quadruplex DNA binding	IDA

GeneCards	WRN
PDB	2FBY, 2FBX, 2AXL, 2E1E, 3AAF, 2FBT, 2FC0, 2FBV, 2E1F, 2DGZ
UniProt	Q14191, Q59F09
MIM	604611
Ensembl	ENSG00000165392
HGNC	12791
HPRD	05212

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RefSeq Accession	Definition	Sequence	Price	Select
NM_000553	Homo sapiens Werner syndrome, RecQ helicase-like (WRN), mRNA.	Full Length	$2594.25
NM_000553		ORF Sequence	$1504.65