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WT1 Wilms tumor 1 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000378 Homo sapiens Wilms tumor 1 (WT1), transcript variant A, mRNA. GenEZ ORF Cloning On-demand TBD TBD
NM_001198551 Homo sapiens Wilms tumor 1 (WT1), transcript variant E, mRNA. GenEZ ORF Cloning On-demand $449.00 14
NM_001198552 Homo sapiens Wilms tumor 1 (WT1), transcript variant F, mRNA. GenEZ ORF Cloning On-demand $449.00 14
NM_024424 Homo sapiens Wilms tumor 1 (WT1), transcript variant B, mRNA. GenEZ ORF Cloning On-demand TBD TBD
NM_024426 Homo sapiens Wilms tumor 1 (WT1), transcript variant D, mRNA. GenEZ ORF Cloning On-demand TBD TBD

*Business Day

Related Services

Gene Symbol WT1
Entrez Gene ID 7490
Full Name Wilms tumor 1
Synonyms AWT1, EWS-WT1, GUD, NPHS4, WAGR, WIT-2, WT33
General protein information
Preferred Names
Wilms tumor protein
Names
Wilms tumor protein
amino-terminal domain of EWS|last three zinc fingers of the DNA-binding domain of WT1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11p13

Summary This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilm's tumors. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation site upstream of and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Oct 2010].
Disorder

MIM: 607102

Wilms tumor, type 1, 194070 (3); Denys-Drash syndrome, 194080 (3);

mRNA Protein Product Sequence Price Select
NM_000378, 309951094 NP_000369, 65507714 Wilms tumor protein isoform A ORF Sequence $550.00
NM_001198551, 309951096 NP_001185480, 309951097 Wilms tumor protein isoform E ORF Sequence $300.00
NM_001198552, 309951098 NP_001185481, 309951099 Wilms tumor protein isoform F ORF Sequence $300.00
NM_024424, 309951093 NP_077742, 65507817 Wilms tumor protein isoform B ORF Sequence $550.00
NM_024426, 309951095 NP_077744, 65508004 Wilms tumor protein isoform D ORF Sequence $550.00
KEGG
hsa05202Transcriptional misregulation in cancer
WikiPathways
WP2377Integrated Pancreatic Cancer Pathway
Pathway Interaction Database
telomerasepathwayRegulation of Telomerase
Homo sapiens (human)WT1NP_077742.2
Pan troglodytes (chimpanzee)WT1XP_001138640.3
Macaca mulatta (Rhesus monkey)WT1XP_001084704.2
Canis lupus familiaris (dog)WT1XP_005631206.1
Bos taurus (cattle)WT1XP_003587050.2
Mus musculus (house mouse)Wt1NP_659032.3
Rattus norvegicus (Norway rat)Wt1NP_113722.2
Gallus gallus (chicken)WT1NP_990547.1
Danio rerio (zebrafish)wt1aNP_571121.1
Xenopus (Silurana) tropicalis (western clawed frog)wt1NP_001135625.1
Process
IDNameEvidence
GO:0000122negative regulation of transcription from RNA polymerase II promoterIDA
GO:0001570vasculogenesisISS
GO:0001657ureteric bud developmentISS
GO:0001658branching involved in ureteric bud morphogenesisIGI
GO:0001822kidney developmentIGI
GO:0003156regulation of organ formationISS
GO:0006309apoptotic DNA fragmentationIDA
GO:0006351transcription, DNA-templatedIEA
GO:0006355regulation of transcription, DNA-templatedISS
GO:0006355regulation of transcription, DNA-templatedNAS
GO:0006357regulation of transcription from RNA polymerase II promoterISS
GO:0007281germ cell developmentISS
GO:0007356thorax and anterior abdomen determinationISS
GO:0007507heart developmentIGI
GO:0007530sex determinationIDA
GO:0008285negative regulation of cell proliferationIDA
GO:0008380RNA splicingISS
GO:0008406gonad developmentISS
GO:0008584male gonad developmentIEP
GO:0009888tissue developmentISS
GO:0017148negative regulation of translationIDA
GO:0030308negative regulation of cell growthIDA
GO:0030325adrenal gland developmentIGI
GO:0030539male genitalia developmentISS
GO:0030855epithelial cell differentiationISS
GO:0032835glomerulus developmentIGI
GO:0032836glomerular basement membrane developmentIMP
GO:0035802adrenal cortex formationISS
GO:0043010camera-type eye developmentISS
GO:0043066negative regulation of apoptotic processIGI
GO:0045892negative regulation of transcription, DNA-templatedIDA
GO:0045893positive regulation of transcription, DNA-templatedIDA
GO:0045893positive regulation of transcription, DNA-templatedIDA
GO:0045893positive regulation of transcription, DNA-templatedIGI
GO:0045944positive regulation of transcription from RNA polymerase II promoterISS
GO:0060231mesenchymal to epithelial transitionISS
GO:0060421positive regulation of heart growthISS
GO:0060539diaphragm developmentISS
GO:0060923cardiac muscle cell fate commitmentISS
GO:0061032visceral serous pericardium developmentIGI
GO:0071320cellular response to cAMPIEP
GO:0071371cellular response to gonadotropin stimulusIDA
GO:0072075metanephric mesenchyme developmentISS
GO:0072112glomerular visceral epithelial cell differentiationIBA
GO:0072112glomerular visceral epithelial cell differentiationISS
GO:0072166posterior mesonephric tubule developmentISS
GO:0072207metanephric epithelium developmentIEP
GO:0072284metanephric S-shaped body morphogenesisIGI
GO:0072302negative regulation of metanephric glomerular mesangial cell proliferationISS
GO:2000020positive regulation of male gonad developmentISS
GO:2000195negative regulation of female gonad developmentISS
GO:2001076positive regulation of metanephric ureteric bud developmentISS
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005654nucleoplasmIDA
GO:0005730nucleolusIDA
GO:0005737cytoplasmIBA
GO:0005737cytoplasmIDA
GO:0005737cytoplasmISS
GO:0016607nuclear speckIDA
Function
IDNameEvidence
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionISS
GO:0003700sequence-specific DNA binding transcription factor activityISS
GO:0003700sequence-specific DNA binding transcription factor activityNAS
GO:0003723RNA bindingIEA
GO:0005515protein bindingIPI
GO:0008270zinc ion bindingIDA
GO:0043565sequence-specific DNA bindingIDA
GO:0044212transcription regulatory region DNA bindingIDA
GO:0070742C2H2 zinc finger domain bindingIPI
GeneCards WT1
UniProt Q6PI38, P19544
Vega OTTHUMG00000039556
MIM 607102
Ensembl ENSG00000184937
HGNC 12796
HPRD 06163

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the WT1 gene?

The WT1 gene provides instructions for making a protein that is necessary for the development of the kidneys and gonads (ovaries in females and testes in males). Within these tissues, the WT1 protein plays a role in cell growth, the process by which cells mature to perform specific functions (cell differentiation), and the self-destruction of cells (apoptosis). To carry out these functions, the WT1 protein regulates the activity of other genes by attaching (binding) to specific regions of DNA. On the basis of this action, the WT1 protein is called a transcription factor.

Interactant

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