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Sequence in raw or FASTA format:

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WT1 Wilms tumor 1 [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_000378 Homo sapiens Wilms tumor 1 (WT1), transcript variant A, mRNA. ORF Sequence $433.26
Peptide Services
Antibody Services
Protein Services
NM_001198551 Homo sapiens Wilms tumor 1 (WT1), transcript variant E, mRNA. ORF Sequence $263.61
Peptide Services
Antibody Services
Protein Services
NM_001198552 Homo sapiens Wilms tumor 1 (WT1), transcript variant F, mRNA. ORF Sequence $251.43
Peptide Services
Antibody Services
Protein Services
NM_024424 Homo sapiens Wilms tumor 1 (WT1), transcript variant B, mRNA. ORF Sequence $448.05
Peptide Services
Antibody Services
Protein Services
NM_024426 Homo sapiens Wilms tumor 1 (WT1), transcript variant D, mRNA. ORF Sequence $450.66
Peptide Services
Antibody Services
Protein Services


Gene Symbol WT1
Entrez Gene ID 7490
Full Name Wilms tumor 1
Synonyms AWT1, GUD, NPHS4, WAGR, WIT-2, WT33
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11p13

Summary This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilm's tumors. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation site upstream of and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Oct 2010].
Disorder

MIM: 607102

Wilms tumor, type 1, 194070 (3); Denys-Drash syndrome, 194080 (3);

mRNA Protein Product Sequence Price Select
NM_000378, 309951094 NP_000369, 65507714 Wilms tumor protein isoform A Full Length $863.33
ORF Sequence $433.26
NM_001198551, 309951096 NP_001185480, 309951097 Wilms tumor protein isoform E Full Length $719.20
ORF Sequence $263.61
NM_001198552, 309951098 NP_001185481, 309951099 Wilms tumor protein isoform F Full Length $707.02
ORF Sequence $251.43
NM_024424, 309951093 NP_077742, 65507817 Wilms tumor protein isoform B Full Length $1059.80
ORF Sequence $448.05
NM_024426, 309951095 NP_077744, 65508004 Wilms tumor protein isoform D Full Length $1062.95
ORF Sequence $450.66
KEGG
hsa05202Transcriptional misregulation in cancer
Pathway Interaction Database
telomerasepathwayRegulation of Telomerase
WikiPathways
WP2377Integrated Pancreatic Cancer Pathway
WP2256Integrated Pancreatic Cancer Pathway
Homo sapiens (human)WT1NP_077744.3
Pan troglodytes (chimpanzee)WT1XP_001138640.3
Macaca mulatta (Rhesus monkey)WT1XP_001084704.2
Canis lupus familiaris (dog)WT1XP_851572.2
Bos taurus (cattle)WT1XP_003587050.1
Mus musculus (house mouse)Wt1NP_659032.3
Rattus norvegicus (Norway rat)Wt1NP_113722.2
Gallus gallus (chicken)WT1NP_990547.1
Danio rerio (zebrafish)wt1aNP_571121.1
GeneCards WT1
PDB 2JPA, 2G7V, 3MYJ, 3HPJ, 2G7T, 2G7X, 2PRT, 2G7W, 1LU6, 2JP9, 1XF7
UniProt Q6PI38, P19544
MIM 607102
Ensembl ENSG00000254922
HGNC 12796
HPRD 06163

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
Wilms tumor protein
Names
Wilms tumor protein
amino-terminal domain of EWS|last three zinc fingers of the DNA-binding domain of WT1

Interactant

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