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XPA xeroderma pigmentosum, complementation group A [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu18921 NM_000380 Homo sapiens xeroderma pigmentosum, complementation group A (XPA), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu43502 XM_006717278 PREDICTED: Homo sapiens xeroderma pigmentosum, complementation group A (XPA), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu18921C NM_000380 Homo sapiens xeroderma pigmentosum, complementation group A (XPA), transcript variant 1, mRNA. Customized vector On-demand 7-9 $209.00
OHu43502C XM_006717278 PREDICTED: Homo sapiens xeroderma pigmentosum, complementation group A (XPA), transcript variant X1, mRNA. Customized vector On-demand 7-9 $209.00

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Gene Symbol XPA
Entrez Gene ID 7507
Full Name xeroderma pigmentosum, complementation group A
Synonyms XP1, XPAC
General protein information
Preferred Names
DNA repair protein complementing XP-A cells
Names
DNA repair protein complementing XP-A cells
excision repair-controlling
xeroderma pigmentosum group A-complementing protein
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

9

9q22.3

Summary This gene encodes a zinc finger protein involved in DNA excision repair. The encoded protein is part of the NER (nucleotide excision repair) complext which is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens. Mutations in this gene are associated with xeroderma pigmentosum complementation group A. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009].
Disorder

MIM: 611153

Xeroderma pigmentosum, group A, 278700 (3)

mRNA Protein Product Sequence Price Select
NM_000380, 156564394 NP_000371, 4507937 DNA repair protein complementing XP-A cells ORF Sequence $300.00
XM_006717278, 578817867 XP_006717341, 578817868 DNA repair protein complementing XP-A cells isoform X1 ORF Sequence $300.00
KEGG
hsa03420Nucleotide excision repair
Reactome
REACT_311Dual incision reaction in GG-NER
REACT_216DNA Repair
REACT_1826Nucleotide Excision Repair
REACT_2253Global Genomic NER (GG-NER)
REACT_257Formation of incision complex in GG-NER
Homo sapiens (human)XPANP_000371.1
Pan troglodytes (chimpanzee)XPAXP_001156167.2
Macaca mulatta (Rhesus monkey)XPAXP_001114093.1
Canis lupus familiaris (dog)XPAXP_538745.2
Bos taurus (cattle)XPANP_001033770.1
Mus musculus (house mouse)XpaNP_035858.2
Rattus norvegicus (Norway rat)XpaNP_001100126.1
Gallus gallus (chicken)XPANP_990184.1
Danio rerio (zebrafish)xpaNP_956765.1
Drosophila melanogaster (fruit fly)XpacNP_476866.1
Caenorhabditis elegansxpa-1NP_492025.1
Xenopus (Silurana) tropicalis (western clawed frog)xpaNP_001016736.1
Process
IDNameEvidence
GO:0000718nucleotide-excision repair, DNA damage removalTAS
GO:0006281DNA repairTAS
GO:0006289nucleotide-excision repairTAS
GO:0006979response to oxidative stressIEA
GO:0008630intrinsic apoptotic signaling pathway in response to DNA damageIEA
GO:0009411response to UVIEA
GO:0009636response to toxic substanceIEA
GO:0035264multicellular organism growthIEA
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005654nucleoplasmTAS
GO:0005662DNA replication factor A complexIDA
GO:0005730nucleolusIDA
GO:0005737cytoplasmIDA
GO:0005794Golgi apparatusIDA
GO:0045171intercellular bridgeIDA
Function
IDNameEvidence
GO:0003684damaged DNA bindingIDA
GO:0005515protein bindingIPI
GO:0019904protein domain specific bindingIPI
GO:0042803protein homodimerization activityIPI
GO:0046872metal ion bindingIEA
GeneCards XPA
PDB 2JNW, 1D4U, 1XPA
UniProt P23025
Vega OTTHUMG00000020330
MIM 611153
Ensembl ENSG00000136936
HGNC 12814
HPRD 02045

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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