Sequence in raw or FASTA format:
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 [
Homo sapiens (human)]
Gene Symbol XRCC1
Entrez Gene ID
Full Name X-ray repair complementing defective repair in Chinese hamster cells 1
General protein information
DNA repair protein XRCC1
DNA repair protein XRCC1
X-ray repair cross-complementing protein 1
X-ray-repair, complementing defective, repair in Chinese hamster
Gene Type protein-coding
Homo sapiens (human)
Chromosome:19 Map Location:19q13.2
Summary The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008].
Pathway Interaction Database
Related articles in PubMed XRCC1 Arg399Gln polymorphism and bladder cancer risk: updated meta-analyses based on 5767 cases and 6919 controls. Zhuo W, et al. Exp Biol Med (Maywood), 2013 Jan 1. PMID 23479765. Polymorphisms in the base excision repair pathway modulate prognosis of platinum-based chemotherapy in advanced non-small cell lung cancer. Zhao W, et al. Cancer Chemother Pharmacol, 2013 May. PMID 23479135. Genetic polymorphisms of CYP2E1 and DNA repair genes HOGG1 and XRCC1: association with hepatitis B related advanced liver disease and cancer. Bose S, et al. Gene, 2013 May 1. PMID 23454624. Association of XRCC1 gene polymorphisms with the survival and clinicopathological characteristics of gastric cancer. Zhang Y, et al. DNA Cell Biol, 2013 Mar. PMID 23425027. Distinct spatiotemporal patterns and PARP dependence of XRCC1 recruitment to single-strand break and base excision repair. Campalans A, et al. Nucleic Acids Res, 2013 Mar 1. PMID 23355608. See all (793) citations in PubMed See citations in PubMed for homologs of this gene provided by HomoloGene
GeneRIFs: Gene References Into Functions
What's a GeneRIF?
XRCC1 and XRCC3 polymorphisms predict poor prognosis in hepatocellular carcinoma.
Title: Study on the DNA repair gene XRCC1 and XRCC3 polymorphism in prediction and prognosis of hepatocellular carcinoma risk.
In HNSCC, mutated homozygous XRCC1 AA was less frequently observed genotype in analyzed groups (YA = 4.7 %, YH = 17.1 %, and OP = 10.8 %). In the YA group, genotype AA occurred significantly less frequently in comparison to YH (OR 0.24, p = 0.0116).
Title: Polymorphisms of DNA repair genes and risk of squamous cell carcinoma of the head and neck in young adults.
XRCC1 Arg399Gln, PARP1 Va1762Ala and APE1 Asp148Glu SNPs in the base excision repair pathway may influence the prognosis of advanced non-small cell lung cancer patients following platinum-based chemotherapy
Title: Polymorphisms in the base excision repair pathway modulate prognosis of platinum-based chemotherapy in advanced non-small cell lung cancer.
XRCC1 Arg399Gln polymorphism may be associated with an increased glioma risk among Asians.
Title: A functional polymorphism in XRCC1 is associated with glioma risk: evidence from a meta-analysis.
XRCC1 expression is associated with adverse clinicopathological and survival outcomes in patients.
Title: Clinicopathological and functional significance of XRCC1 expression in ovarian cancer.
This meta-analysis suggested that the XRCC1 Arg399Gln polymorphism is moderately associated with increased risk of gliomas in Asians, while Arg194Trp and Arg280His polymorphisms demonstrated no significant influence.
Title: Association between XRCC1 gene polymorphisms and risk of glioma development: a meta-analysis.
XRCC1 194Trp/Trp genotype was strongly significantly associated with an increased risk of hepatocellular carcinoma when compared with the wild-type genotype.
Title: Association of XPD and XRCC1 genetic polymorphisms with hepatocellular carcinoma risk.
XRCC1 Arg194Trp and XRCC1Arg399Gln single nucleotide polymorphisma were related to the metabolism of platinum-based chemotherapy, and could be used as predictors of clinical outcome of non-small cell lung cancer.
Title: Prognostic significance of GSTP1, XRCC1 and XRCC3 polymorphisms in non-small cell lung cancer patients.
The genetic polymorphisms of CYP1A1-exon7, GSTM1, XRCC1-194 and XRCC1-280 might contribute to the risk of developing lung cancer in Henan population.
Title: [Association between genetic polymorphism of metabolizing enzymes and DNA repairing enzymes and the susceptibility of lung cancer in Henan population].
XRCC1 was associated with liver cancer in the Pakistani population.
Title: Association of XRCC1, XRCC3, and XPD genetic polymorphism with an increased risk of hepatocellular carcinoma because of the hepatitis B and C virus.
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