XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 [Homo sapiens (human)]
| Gene Symbol | XRCC1 |
| Entrez Gene ID | 7515 |
| Full Name | X-ray repair complementing defective repair in Chinese hamster cells 1 |
| Synonyms | RCC |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
19 19q13.2 |
| Summary | The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq]. |
| Disorder | MIM: 194360 |
| mRNA | NM_006297, 190684674 |
| Protein | NP_006288, 190684675 |
| Product | DNA repair protein XRCC1 |
| RefSeq Status | REVIEWED |
| hsa03410 | Base excision repair |
Pathway Interaction Database
| e2f_pathway | E2F transcription factor network |
| foxm1pathway | FOXM1 transcription factor network |
Reactome
| REACT_1104 | Base Excision Repair |
| REACT_933 | Resolution of AP sites via the single-nucleotide replacement pathway |
| REACT_216 | DNA Repair |
| REACT_1893 | Resolution of Abasic Sites (AP sites) |
| Homo sapiens (human) | XRCC1 | NP_006288.2 |
| Pan troglodytes (chimpanzee) | XRCC1 | XP_512717.2 |
| Canis lupus familiaris (dog) | XRCC1 | XP_533653.2 |
| Mus musculus (house mouse) | Xrcc1 | NP_033558.2 |
| Rattus norvegicus (Norway rat) | Xrcc1 | NP_445887.1 |
| Danio rerio (zebrafish) | zgc:91996 | NP_001003988.1 |
| Danio rerio (zebrafish) | LOC100333367 | XP_002667489.1 |
| ID | Name | Evidence |
| GO:0000012 | single strand break repair | IEA |
| GO:0001666 | response to hypoxia | IEA |
| GO:0006281 | DNA repair | TAS |
| GO:0006284 | base-excision repair | TAS |
| GO:0010033 | response to organic substance | IEA |
| GO:0042493 | response to drug | IEA |
Component
| ID | Name | Evidence |
| GO:0005622 | intracellular | IEA |
| GO:0005634 | nucleus | IDA |
| GO:0005654 | nucleoplasm | EXP |
| GO:0005654 | nucleoplasm | TAS |
Function
| ID | Name | Evidence |
| GO:0003684 | damaged DNA binding | IEA |
| GO:0005515 | protein binding | IPI |
Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.
 |
Secured Online Quotation |
 |
Email: gene@genscript.com |
 |
Phone: 1-877-436-7274 (Toll-Free) 1-732-885-9188 |
 |
Fax: 1-732-210-0262 1-732-885-5878 |