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Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu20078 NM_006297 Homo sapiens X-ray repair complementing defective repair in Chinese hamster cells 1 (XRCC1), mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu20078C NM_006297 Homo sapiens X-ray repair complementing defective repair in Chinese hamster cells 1 (XRCC1), mRNA. Customized vector In-stock 5-7 $149.00

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Gene Symbol XRCC1
Entrez Gene ID 7515
Full Name X-ray repair complementing defective repair in Chinese hamster cells 1
Synonyms RCC
General protein information
Preferred Names
DNA repair protein XRCC1
Names
DNA repair protein XRCC1
X-ray repair cross-complementing protein 1
X-ray-repair, complementing defective, repair in Chinese hamster
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

19

19q13.2

Summary The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008].
Disorder

MIM: 194360

mRNA Protein Product Sequence Price Select
NM_006297, 190684674 NP_006288, 190684675 DNA repair protein XRCC1 ORF Sequence $490.00
KEGG
hsa03410Base excision repair
hsa_M00296BER complex
Pathway Interaction Database
foxm1pathwayFOXM1 transcription factor network
e2f_pathwayE2F transcription factor network
Reactome
REACT_1893Resolution of Abasic Sites (AP sites)
REACT_1104Base Excision Repair
REACT_216DNA Repair
REACT_933Resolution of AP sites via the single-nucleotide replacement pathway
Homo sapiens (human)XRCC1NP_006288.2
Pan troglodytes (chimpanzee)XRCC1XP_001156934.3
Macaca mulatta (Rhesus monkey)XRCC1XP_001100256.2
Canis lupus familiaris (dog)XRCC1XP_533653.3
Bos taurus (cattle)XRCC1XP_005219459.1
Mus musculus (house mouse)Xrcc1NP_033558.3
Rattus norvegicus (Norway rat)Xrcc1NP_445887.1
Danio rerio (zebrafish)xrcc1NP_001003988.1
Xenopus (Silurana) tropicalis (western clawed frog)xrcc1XP_002939185.2
Process
IDNameEvidence
GO:0000012single strand break repairIEA
GO:0001666response to hypoxiaIEA
GO:0006281DNA repairTAS
GO:0006284base-excision repairIBA
GO:0006284base-excision repairTAS
GO:0010033response to organic substanceIEA
GO:0021766hippocampus developmentIEA
GO:0042493response to drugIEA
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005654nucleoplasmTAS
Function
IDNameEvidence
GO:0003684damaged DNA bindingIEA
GO:0005515protein bindingIPI
GeneCards XRCC1
PDB 1CDZ, 1XNT, 3LQC, 1XNA, 2D8M, 2W3O, 3K77, 3K75
UniProt Q59HH7, B2RCY5, P18887
Vega OTTHUMG00000182699
MIM 194360
Ensembl ENSG00000073050
HGNC 12828
HPRD 01909

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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