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Sequence in raw or FASTA format:

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XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001100118 Homo sapiens X-ray repair complementing defective repair in Chinese hamster cells 3 (XRCC3), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_001100119 Homo sapiens X-ray repair complementing defective repair in Chinese hamster cells 3 (XRCC3), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_005432 Homo sapiens X-ray repair complementing defective repair in Chinese hamster cells 3 (XRCC3), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $549.00 14
XM_005268046 PREDICTED: Homo sapiens X-ray repair complementing defective repair in Chinese hamster cells 3 (XRCC3), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $549.00 14

*Business Day

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Gene Symbol XRCC3
Entrez Gene ID 7517
Full Name X-ray repair complementing defective repair in Chinese hamster cells 3
Synonyms CMM6
General protein information
Preferred Names
DNA repair protein XRCC3
Names
DNA repair protein XRCC3
X-ray repair cross-complementing protein 3
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

14

14q32.3

Summary This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008].
Disorder

MIM: 600675

{Melanoma, cutaneous malignant, susceptibility to, 6} (3); {Breast

mRNA Protein Product Sequence Price Select
NM_001100118, 153946426 NP_001093588, 153946427 DNA repair protein XRCC3 ORF Sequence $400.00
NM_001100119, 153946429 NP_001093589, 153946430 DNA repair protein XRCC3 ORF Sequence $400.00
NM_005432, 153946428 NP_005423, 4885659 DNA repair protein XRCC3 ORF Sequence $400.00
XM_005268046, 530404581 XP_005268103, 530404582 DNA repair protein XRCC3 isoform X2 ORF Sequence $400.00
KEGG
hsa03440Homologous recombination
WikiPathways
WP1984Integrated Breast Cancer Pathway
WP1601Fluoropyrimidine Activity
Homo sapiens (human)XRCC3NP_001093588.1
Pan troglodytes (chimpanzee)XRCC3XP_003314577.1
Macaca mulatta (Rhesus monkey)XRCC3XP_001083970.1
Canis lupus familiaris (dog)XRCC3XP_003435154.1
Bos taurus (cattle)XRCC3NP_001071585.1
Mus musculus (house mouse)Xrcc3NP_083151.1
Rattus norvegicus (Norway rat)LOC102551085XP_006240711.1
Gallus gallus (chicken)XRCC3NP_001006489.1
Danio rerio (zebrafish)xrcc3NP_001013559.1
Drosophila melanogaster (fruit fly)spn-BNP_476740.1
Arabidopsis thaliana (thale cress)XRCC3NP_851202.1
Xenopus (Silurana) tropicalis (western clawed frog)xrcc3NP_001016141.1
Process
IDNameEvidence
GO:0000724double-strand break repair via homologous recombinationIMP
GO:0000737DNA catabolic process, endonucleolyticIMP
GO:0006200ATP catabolic processIEA
GO:0006281DNA repairIGI
GO:0006310DNA recombinationTAS
GO:0006974cellular response to DNA damage stimulusTAS
GO:0010033response to organic substanceIEA
GO:0010824regulation of centrosome duplicationIMP
GO:0071140resolution of mitotic recombination intermediatesIMP
GO:0090267positive regulation of mitotic cell cycle spindle assembly checkpointIMP
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005657replication forkIDA
GO:0005737cytoplasmIDA
GO:0005739mitochondrionIDA
GO:0033065Rad51C-XRCC3 complexIDA
GO:0048471perinuclear region of cytoplasmIDA
Function
IDNameEvidence
GO:0000400four-way junction DNA bindingIDA
GO:0005515protein bindingIPI
GO:0005524ATP bindingIEA
GO:0008094DNA-dependent ATPase activityIEA
GO:0008821crossover junction endodeoxyribonuclease activityIMP
GeneCards XRCC3
UniProt O43542, Q53XC8
Vega OTTHUMG00000169228
MIM 600675
Ensembl ENSG00000126215
HGNC 12830
HPRD 07201

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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