XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3 [Homo sapiens (human)]
| Gene Symbol | XRCC3 |
| Entrez Gene ID | 7517 |
| Full Name | X-ray repair complementing defective repair in Chinese hamster cells 3 |
| Synonyms | CMM6 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
14 14q32.3 |
| Summary | This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq]. |
| Disorder | MIM: 600675 {Melanoma, cutaneous malignant, susceptibility to, 6} (3); {Breast |
| mRNA | NM_001100118, 153946426 |
| Protein | NP_001093588, 153946427 |
| Product | DNA repair protein XRCC3 |
| RefSeq Status | REVIEWED |
| mRNA | NM_005432, 153946428 |
| Protein | NP_005423, 4885659 |
| Product | DNA repair protein XRCC3 |
| RefSeq Status | REVIEWED |
| mRNA | NM_001100119, 153946429 |
| Protein | NP_001093589, 153946430 |
| Product | DNA repair protein XRCC3 |
| RefSeq Status | REVIEWED |
| Homo sapiens (human) | XRCC3 | NP_001093588.1 |
| Bos taurus (cattle) | XRCC3 | NP_001071585.1 |
| Mus musculus (house mouse) | Xrcc3 | NP_083151.1 |
| Gallus gallus (chicken) | XRCC3 | NP_001006489.1 |
| Danio rerio (zebrafish) | xrcc3 | NP_001013559.1 |
| Drosophila melanogaster (fruit fly) | spn-B | NP_476740.1 |
| Arabidopsis thaliana (thale cress) | XRCC3 | NP_200554.1 |
| ID | Name | Evidence |
| GO:0006281 | DNA repair | IGI |
| GO:0006310 | DNA recombination | IEA |
| GO:0006974 | response to DNA damage stimulus | TAS |
Component
| ID | Name | Evidence |
| GO:0005634 | nucleus | IDA |
| GO:0005737 | cytoplasm | IDA |
| GO:0005739 | mitochondrion | IDA |
| GO:0048471 | perinuclear region of cytoplasm | IDA |
Function
| ID | Name | Evidence |
| GO:0000166 | nucleotide binding | IEA |
| GO:0003677 | DNA binding | IEA |
| GO:0005524 | ATP binding | IEA |
| GO:0008094 | DNA-dependent ATPase activity | IEA |
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