YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide [Homo sapiens (human)]
| Gene Symbol | YWHAH |
| Entrez Gene ID | 7533 |
| Full Name | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide |
| Synonyms | YWHA1 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
22 22q12.3 |
| Summary | This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder. [provided by RefSeq]. |
| Disorder | MIM: 113508 |
| mRNA | NM_003405, 61744461 |
| Protein | NP_003396, 4507951 |
| Product | 14-3-3 protein eta |
| RefSeq Status | REVIEWED |
| hsa04722 | Neurotrophin signaling pathway |
| hsa04110 | Cell cycle |
| hsa04114 | Oocyte meiosis |
Pathway Interaction Database
| pi3kciaktpathway | Class I PI3K signaling events mediated by Akt |
| mtor_4pathway | mTOR signaling pathway |
| nfat_3pathway | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| foxopathway | FoxO family signaling |
| erbb1_downstream_pathway | ErbB1 downstream signaling |
| insulin_glucose_pathway | Insulin-mediated glucose transport |
| a6b1_a6b4_integrin_pathway | a6b1 and a6b4 Integrin signaling |
| pi3kplctrkpathway | Trk receptor signaling mediated by PI3K and PLC-gamma |
| lkb1_pathway | LKB1 signaling events |
| reg_gr_pathway | Glucocorticoid receptor regulatory network |
| wnt_beta_catenin_pathway | Regulation of Wnt-mediated beta catenin signaling and target gene transcription |
| p38_mk2pathway | p38 signaling mediated by MAPKAP kinases |
WikiPathways
| WP244 | Alpha6-Beta4 Integrin Signaling Pathway |
| WP289 | Myometrial Relaxation and Contraction Pathways |
| WP536 | Calcium Regulation in the Cardiac Cell |
| WP138 | Androgen Receptor Signaling Pathway |
| WP231 | TNF-alpha/NF-kB Signaling Pathway |
| Homo sapiens (human) | YWHAH | NP_003396.1 |
| Pan troglodytes (chimpanzee) | YWHAH | XP_001151357.1 |
| Bos taurus (cattle) | YWHAH | NP_776917.2 |
| Mus musculus (house mouse) | Ywhah | NP_035868.1 |
| Rattus norvegicus (Norway rat) | Ywhah | NP_037184.1 |
| Gallus gallus (chicken) | YWHAH | NP_001007840.1 |
| Danio rerio (zebrafish) | ywhah | NP_998329.1 |
| ID | Name | Evidence |
| GO:0006713 | glucocorticoid catabolic process | IDA |
| GO:0006886 | intracellular protein transport | ISS |
| GO:0042921 | glucocorticoid receptor signaling pathway | IDA |
| GO:0045664 | regulation of neuron differentiation | ISS |
| GO:0045893 | positive regulation of transcription, DNA-dependent | IDA |
| GO:0048167 | regulation of synaptic plasticity | ISS |
| GO:0050774 | negative regulation of dendrite morphogenesis | ISS |
Component
| ID | Name | Evidence |
| GO:0005737 | cytoplasm | ISS |
Function
| ID | Name | Evidence |
| GO:0003779 | actin binding | IEA |
| GO:0005159 | insulin-like growth factor receptor binding | ISS |
| GO:0005515 | protein binding | IPI |
| GO:0019899 | enzyme binding | IPI |
| GO:0019904 | protein domain specific binding | ISS |
| GO:0035259 | glucocorticoid receptor binding | IPI |
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