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YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta [Homo sapiens (human)]

Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu29420D NM_003405 Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta (YWHAH), mRNA. pcDNA3.1-C-(k)DYK In-stock 5-7 Starting from $99
OHu29420C NM_003405 Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta (YWHAH), mRNA. Customized vector In-stock 5-7 Starting from $99

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Gene Symbol YWHAH
Entrez Gene ID 7533
Full Name tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
Synonyms YWHA1
General protein information
Preferred Names
14-3-3 protein eta
14-3-3 protein eta
14-3-3 eta
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder. [provided by RefSeq, Jun 2009].

MIM: 113508

mRNA Protein Product Sequence Price Select
NM_003405, 61744461 NP_003396, 4507951 14-3-3 protein eta ORF Sequence $159.00
hsa04110Cell cycle
hsa04114Oocyte meiosis
hsa04151PI3K-Akt signaling pathway
hsa04390Hippo signaling pathway
hsa05169Epstein-Barr virus infection
hsa05203Viral carcinogenesis
WP244Alpha6-Beta4 Integrin Signaling Pathway
WP289Myometrial Relaxation and Contraction Pathways
WP179Cell cycle
WP231TNF-alpha/NF-kB Signaling Pathway
WP706SIDS Susceptibility Pathways
WP536Calcium Regulation in the Cardiac Cell
Pathway Interaction Database
lkb1_pathwayLKB1 signaling events
insulin_glucose_pathwayInsulin-mediated glucose transport
pi3kciaktpathwayClass I PI3K signaling events mediated by Akt
nfat_3pathwayRole of Calcineurin-dependent NFAT signaling in lymphocytes
pi3kplctrkpathwayTrk receptor signaling mediated by PI3K and PLC-gamma
reg_gr_pathwayGlucocorticoid receptor regulatory network
erbb1_downstream_pathwayErbB1 downstream signaling
a6b1_a6b4_integrin_pathwaya6b1 and a6b4 Integrin signaling
p38_mk2pathwayp38 signaling mediated by MAPKAP kinases
foxopathwayFoxO family signaling
mtor_4pathwaymTOR signaling pathway
wnt_beta_catenin_pathwayRegulation of Wnt-mediated beta catenin signaling and target gene transcription
REACT_549Activation of BAD and translocation to mitochondria
REACT_964Intrinsic Pathway for Apoptosis
REACT_697Activation of BH3-only proteins
REACT_11123Membrane Trafficking
REACT_147867Translocation of GLUT4 to the plasma membrane
Homo sapiens (human)YWHAHNP_003396.1
Pan troglodytes (chimpanzee)YWHAHXP_001151423.1
Macaca mulatta (Rhesus monkey)YWHAHXP_001111998.1
Canis lupus familiaris (dog)YWHAHXP_003433473.2
Bos taurus (cattle)YWHAHNP_776917.2
Mus musculus (house mouse)YwhahNP_035868.1
Rattus norvegicus (Norway rat)YwhahNP_037184.1
Gallus gallus (chicken)YWHAHNP_001007840.1
Danio rerio (zebrafish)ywhahNP_998329.1
Xenopus (Silurana) tropicalis (western clawed frog)ywhahNP_001016868.1
GO:0002028regulation of sodium ion transportIDA
GO:0006713glucocorticoid catabolic processIDA
GO:0006886intracellular protein transportISS
GO:0006915apoptotic processTAS
GO:0021762substantia nigra developmentIEP
GO:0042921glucocorticoid receptor signaling pathwayIDA
GO:0045664regulation of neuron differentiationISS
GO:0045893positive regulation of transcription, DNA-templatedIDA
GO:0048167regulation of synaptic plasticityISS
GO:0050774negative regulation of dendrite morphogenesisISS
GO:0061024membrane organizationTAS
GO:0086010membrane depolarization during action potentialIDA
GO:0097193intrinsic apoptotic signaling pathwayTAS
GO:1900740positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathwayTAS
GO:2000649regulation of sodium ion transmembrane transporter activityIDA
GO:0005886plasma membraneIDA
GO:0014704intercalated discIC
GO:0030659cytoplasmic vesicle membraneTAS
GO:0070062extracellular vesicular exosomeIDA
GO:0003779actin bindingIEA
GO:0005159insulin-like growth factor receptor bindingISS
GO:0005515protein bindingIPI
GO:0017080sodium channel regulator activityIDA
GO:0019899enzyme bindingIPI
GO:0019904protein domain specific bindingISS
GO:0035259glucocorticoid receptor bindingIPI
GO:0044325ion channel bindingIPI
GO:0046982protein heterodimerization activityIPI
GeneCards YWHAH
PDB 2C63, 2C74
UniProt Q9H4N8, Q04917
Vega OTTHUMG00000030833
MIM 113508
Ensembl ENSG00000128245
HGNC 12853
HPRD 00215

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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