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ZBTB16 zinc finger and BTB domain containing 16 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu04229 NM_001018011 Homo sapiens zinc finger and BTB domain containing 16 (ZBTB16), transcript variant 2, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu04229 NM_006006 Homo sapiens zinc finger and BTB domain containing 16 (ZBTB16), transcript variant 1, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu45861 XM_006718899 PREDICTED: Homo sapiens zinc finger and BTB domain containing 16 (ZBTB16), transcript variant X3, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu45862 XM_005271658 PREDICTED: Homo sapiens zinc finger and BTB domain containing 16 (ZBTB16), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu04229C NM_001018011 Homo sapiens zinc finger and BTB domain containing 16 (ZBTB16), transcript variant 2, mRNA. Customized vector In-stock 5-7 $149.00
OHu04229C NM_006006 Homo sapiens zinc finger and BTB domain containing 16 (ZBTB16), transcript variant 1, mRNA. Customized vector In-stock 5-7 $149.00
OHu45861C XM_006718899 PREDICTED: Homo sapiens zinc finger and BTB domain containing 16 (ZBTB16), transcript variant X3, mRNA. Customized vector On-demand 7-9 $269.00
OHu45862C XM_005271658 PREDICTED: Homo sapiens zinc finger and BTB domain containing 16 (ZBTB16), transcript variant X2, mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol ZBTB16
Entrez Gene ID 7704
Full Name zinc finger and BTB domain containing 16
Synonyms PLZF, ZNF145
General protein information
Preferred Names
zinc finger and BTB domain-containing protein 16
Names
zinc finger and BTB domain-containing protein 16
zinc finger protein PLZF
zinc finger protein 145 (Kruppel-like, expressed in promyelocytic leukemia)
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11q23.1

Summary This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008].
Disorder

MIM: 176797

Leukemia, acute promyelocytic, PL2F/RARA type (3); Skeletal defects,

mRNA Protein Product Sequence Price Select
NM_001018011, 66932931 NP_001018011, 66932932 zinc finger and BTB domain-containing protein 16 ORF Sequence $490.00
NM_006006, 66932930 NP_005997, 21359888 zinc finger and BTB domain-containing protein 16 ORF Sequence $490.00
XM_005271658, 578822361 XP_005271715, 530398348 zinc finger and BTB domain-containing protein 16 isoform X2 ORF Sequence $550.00
XM_006718899, 578822359 XP_006718962, 578822360 zinc finger and BTB domain-containing protein 16 isoform X3 ORF Sequence $550.00
KEGG
hsa05221Acute myeloid leukemia
hsa05200Pathways in cancer
hsa05202Transcriptional misregulation in cancer
Reactome
REACT_6900Immune System
REACT_75774Adaptive Immune System
REACT_75820Class I MHC mediated antigen processing & presentation
REACT_75842Antigen processing: Ubiquitination & Proteasome degradation
Homo sapiens (human)ZBTB16NP_001018011.1
Pan troglodytes (chimpanzee)ZBTB16XP_003313422.1
Macaca mulatta (Rhesus monkey)ZBTB16XP_001086244.1
Canis lupus familiaris (dog)ZBTB16XP_005619812.1
Bos taurus (cattle)ZBTB16NP_001032553.1
Mus musculus (house mouse)Zbtb16NP_001028496.1
Rattus norvegicus (Norway rat)Zbtb16NP_001013199.1
Gallus gallus (chicken)ZBTB16XP_417898.3
Danio rerio (zebrafish)zbtb16aNP_955929.1
Xenopus (Silurana) tropicalis (western clawed frog)zbtb16XP_004916153.1
Process
IDNameEvidence
GO:0001823mesonephros developmentISS
GO:0006351transcription, DNA-templatedIEA
GO:0006915apoptotic processNAS
GO:0007417central nervous system developmentISS
GO:0008285negative regulation of cell proliferationIEA
GO:0009880embryonic pattern specificationIEA
GO:0009952anterior/posterior pattern specificationIEA
GO:0016567protein ubiquitinationIEA
GO:0030097hemopoiesisIDA
GO:0030097hemopoiesisTAS
GO:0030099myeloid cell differentiationTAS
GO:0032332positive regulation of chondrocyte differentiationIMP
GO:0034504protein localization to nucleusIEA
GO:0035116embryonic hindlimb morphogenesisIEA
GO:0035136forelimb morphogenesisIEA
GO:0042733embryonic digit morphogenesisIEA
GO:0043065positive regulation of apoptotic processIEA
GO:0045600positive regulation of fat cell differentiationIMP
GO:0045638negative regulation of myeloid cell differentiationISS
GO:0045778positive regulation of ossificationIDA
GO:0045892negative regulation of transcription, DNA-templatedIDA
GO:0045892negative regulation of transcription, DNA-templatedNAS
GO:0045893positive regulation of transcription, DNA-templatedIDA
GO:0048133male germ-line stem cell divisionIEA
GO:0051216cartilage developmentIDA
GO:0061036positive regulation of cartilage developmentIDA
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005829cytosolIEA
GO:0005886plasma membraneIEA
GO:0016604nuclear bodyIDA
GO:0016605PML bodyIDA
GO:0016607nuclear speckIDA
GO:0017053transcriptional repressor complexIDA
Function
IDNameEvidence
GO:0003677DNA bindingIDA
GO:0003677DNA bindingNAS
GO:0003690double-stranded DNA bindingIEA
GO:0003700sequence-specific DNA binding transcription factor activityIEA
GO:0005515protein bindingIPI
GO:0008022protein C-terminus bindingIEA
GO:0019904protein domain specific bindingIEA
GO:0042802identical protein bindingIPI
GO:0042803protein homodimerization activityIDA
GO:0046872metal ion bindingIEA
GeneCards ZBTB16
UniProt Q05516
Vega OTTHUMG00000168243
MIM 176797
Ensembl ENSG00000109906
HGNC 12930
HPRD 11762

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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