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ZP3 zona pellucida glycoprotein 3 (sperm receptor) [Homo sapiens (human)]


RefSeq Accession Definition Sequence Price Select
NM_001110354 Homo sapiens zona pellucida glycoprotein 3 (sperm receptor) (ZP3), transcript variant 1, mRNA. Full Length $381.93
ORF Sequence $369.75
NM_007155 Homo sapiens zona pellucida glycoprotein 3 (sperm receptor) (ZP3), transcript variant 2, mRNA. Full Length $433.26
ORF Sequence $325.38


Gene Symbol ZP3
Entrez Gene ID 7784
Full Name zona pellucida glycoprotein 3 (sperm receptor)
Synonyms ZP3A, ZP3B, ZPC, Zp-3
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

7

7q11.23
Summary The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus; however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene. [provided by RefSeq].
Disorder

MIM: 182889
mRNA NM_001110354, 160358849
Protein NP_001103824, 160358850
Product zona pellucida sperm-binding protein 3 isoform 1 precursor
RefSeq Status REVIEWED
mRNA NM_007155, 160358848
Protein NP_009086, 38327649
Product zona pellucida sperm-binding protein 3 isoform 2
RefSeq Status REVIEWED
WikiPathways
WP34Ovarian Infertility Genes
Homo sapiens (human)ZP3NP_001103824.1
Pan troglodytes (chimpanzee)ZP3XP_528035.2
Canis lupus familiaris (dog)ZP3NP_001003224.1
Bos taurus (cattle)ZP3NP_776399.1
Mus musculus (house mouse)Zp3NP_035906.1
Rattus norvegicus (Norway rat)Zp3NP_446214.1
Gallus gallus (chicken)ZP3XP_413693.2
Gallus gallus (chicken)ZP3NP_989720.1
Gallus gallus (chicken)ZP3XP_413701.2
Danio rerio (zebrafish)zgc:171779NP_001103303.1
Danio rerio (zebrafish)zp3a.1NP_001013289.1
Danio rerio (zebrafish)zp3.1NP_001103211.1
Danio rerio (zebrafish)zp3.2NP_001020357.1
Danio rerio (zebrafish)zp3a.2NP_001025291.1
Danio rerio (zebrafish)zgc:173556NP_001103212.1
Danio rerio (zebrafish)zp3NP_571406.1
Process
IDNameEvidence
GO:0001809positive regulation of type IV hypersensitivityISS
GO:0001825blastocyst formationISS
GO:0002455humoral immune response mediated by circulating immunoglobulinISS
GO:0002687positive regulation of leukocyte migrationISS
GO:0002922positive regulation of humoral immune responseIDA
GO:0006828manganese ion transportISS
GO:0006886intracellular protein transportISS
GO:0007338single fertilizationIEA
GO:0007339binding of sperm to zona pellucidaIDA
GO:0007339binding of sperm to zona pellucidaIGI
GO:0007339binding of sperm to zona pellucidaIMP
GO:0010513positive regulation of phosphatidylinositol biosynthetic processISS
GO:0032234regulation of calcium ion transport via store-operated calcium channel activityIDA
GO:0032236positive regulation of calcium ion transport via store-operated calcium channel activityISS
GO:0032729positive regulation of interferon-gamma productionISS
GO:0032753positive regulation of interleukin-4 productionISS
GO:0035556intracellular signal transductionIMP
GO:0035803egg coat formationISS
GO:0042102positive regulation of T cell proliferationISS
GO:0045860positive regulation of protein kinase activityIDA
GO:0045892negative regulation of transcription, DNA-dependentISS
GO:0045893positive regulation of transcription, DNA-dependentISS
GO:0048015phosphatidylinositol-mediated signalingISS
GO:0048599oocyte developmentISS
GO:0050729positive regulation of inflammatory responseISS
GO:0051897positive regulation of protein kinase B signaling cascadeISS
GO:0070528protein kinase C signaling cascadeIMP
GO:0071421manganese ion transmembrane transportISS
GO:0090280positive regulation of calcium ion importIDA
GO:2000344positive regulation of acrosome reactionIDA
GO:2000360negative regulation of binding of sperm to zona pellucidaIDA
GO:2000368positive regulation of acrosomal vesicle exocytosisIDA
GO:2000368positive regulation of acrosomal vesicle exocytosisIMP
GO:2000386positive regulation of ovarian follicle developmentISS
GO:2000388positive regulation of antral ovarian follicle growthISS
Component
IDNameEvidence
GO:0001669acrosomal vesicleISS
GO:0002081outer acrosomal membraneISS
GO:0005576extracellular regionIEA
GO:0005578proteinaceous extracellular matrixIEA
GO:0005615extracellular spaceIMP
GO:0005737cytoplasmIDA
GO:0005771multivesicular bodyISS
GO:0005783endoplasmic reticulumISS
GO:0005794Golgi apparatusISS
GO:0005886plasma membraneISS
GO:0016021integral to membraneIEA
GO:0030141stored secretory granuleISS
GO:0031012extracellular matrixIDA
GO:0048471perinuclear region of cytoplasmISS
Function
IDNameEvidence
GO:0004871signal transducer activityIMP
GO:0004872receptor activityIEA
GO:0005384manganese ion transmembrane transporter activityISS
GO:0005515protein bindingIPI
GO:0005529sugar bindingIDA
GO:0032190acrosin bindingIPI
GeneCards ZP3
UniProt P21754
MIM 182889
Ensembl ENSG00000188372
HGNC 13189
HPRD 01690

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