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ZP3 zona pellucida glycoprotein 3 (sperm receptor) [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_001110354 Homo sapiens zona pellucida glycoprotein 3 (sperm receptor) (ZP3), transcript variant 1, mRNA. ORF Sequence $369.75
Peptide Services
Antibody Services
Protein Services
NM_007155 Homo sapiens zona pellucida glycoprotein 3 (sperm receptor) (ZP3), transcript variant 2, mRNA. ORF Sequence $325.38
Peptide Services
Antibody Services
Protein Services


Gene Symbol ZP3
Entrez Gene ID 7784
Full Name zona pellucida glycoprotein 3 (sperm receptor)
Synonyms ZP3A, ZP3B, ZPC, Zp-3
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

7

7q11.23

Summary The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus; however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene. [provided by RefSeq, Jul 2008].
Disorder

MIM: 182889

mRNA Protein Product Sequence Price Select
NM_001110354, 160358849 NP_001103824, 160358850 zona pellucida sperm-binding protein 3 isoform 1 precursor Full Length $381.93
ORF Sequence $369.75
NM_007155, 160358848 NP_009086, 38327649 zona pellucida sperm-binding protein 3 isoform 2 Full Length $433.26
ORF Sequence $325.38
WikiPathways
WP34Ovarian Infertility Genes
Homo sapiens (human)ZP3NP_001103824.1
Pan troglodytes (chimpanzee)ZP3XP_528035.3
Macaca mulatta (Rhesus monkey)ZP3XP_002803282.1
Canis lupus familiaris (dog)ZP3NP_001003224.1
Bos taurus (cattle)ZP3NP_776399.1
Mus musculus (house mouse)Zp3NP_035906.1
Rattus norvegicus (Norway rat)Zp3NP_446214.1
Gallus gallus (chicken)ZP3NP_989720.2
Gallus gallus (chicken)LOC415314XP_413701.3
Gallus gallus (chicken)ZP3XP_413693.2
Danio rerio (zebrafish)zgc:171779NP_001103303.1
Danio rerio (zebrafish)zp3a.1NP_001013289.1
Danio rerio (zebrafish)zp3a.2NP_001025291.1
Danio rerio (zebrafish)zp3.2NP_001020357.1
Danio rerio (zebrafish)zgc:173556NP_001103212.1
Danio rerio (zebrafish)zp3NP_571406.1
Danio rerio (zebrafish)LOC100536860XP_003200340.1
Danio rerio (zebrafish)zp3.1NP_001103211.1
GeneCards ZP3
UniProt P21754
MIM 182889
Ensembl ENSG00000188372
HGNC 13189
HPRD 01690

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
zona pellucida sperm-binding protein 3
Names
zona pellucida sperm-binding protein 3
ZP3A/ZP3B
sperm receptor
zona pellucida protein C
zona pellucida glycoprotein 3B
zona pellucida glycoprotein ZP3
zona pellucida glycoprotein 3A (sperm receptor)

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