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TUBA1A tubulin, alpha 1a [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001270399 Homo sapiens tubulin, alpha 1a (TUBA1A), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_001270400 Homo sapiens tubulin, alpha 1a (TUBA1A), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_006009 Homo sapiens tubulin, alpha 1a (TUBA1A), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $699.00 18

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Gene Symbol TUBA1A
Entrez Gene ID 7846
Full Name tubulin, alpha 1a
Synonyms B-ALPHA-1, FLJ25113, LIS3, TUBA3
Gene Type protein-coding
Organism Homo sapiens (human)



Summary Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blotting studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q. Mutations in this gene cause lissencephaly type 3 (LIS3) - a neurological condition characterized by microcephaly, mental retardation, and early-onset epilepsy and caused by defective neuronal migration. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012].

MIM: 602529

Lissencephaly 3, 611603 (3)

mRNA Protein Product Sequence Price Select
NM_001270399, 393715090 NP_001257328, 393715091 tubulin alpha-1A chain isoform 1 ORF Sequence $550.00
NM_001270400, 393715094 NP_001257329, 393715095 tubulin alpha-1A chain isoform 2 ORF Sequence $550.00
NM_006009, 393715088 NP_006000, 17986283 tubulin alpha-1A chain isoform 1 ORF Sequence $550.00
hsa04540Gap junction
hsa05130Pathogenic Escherichia coli infection
WP2359Parkin-Ubiquitin Proteasomal System pathway
WP2272Pathogenic Escherichia coli infection
REACT_21391Mitotic G2-G2/M phases
REACT_15479Centrosome maturation
REACT_16936Prefoldin mediated transfer of substrate to CCT/TriC
REACT_17004Chaperonin-mediated protein folding
REACT_152Cell Cycle, Mitotic
REACT_16952Protein folding
REACT_2203G2/M Transition
REACT_17029Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
REACT_15296Recruitment of mitotic centrosome proteins and complexes
REACT_15364Loss of Nlp from mitotic centrosomes
REACT_16956Formation of tubulin folding intermediates by CCT/TriC
REACT_15451Loss of proteins required for interphase microtubule organization####from the centrosome
REACT_17015Metabolism of proteins
REACT_16967Post-chaperonin tubulin folding pathway
REACT_115566Cell Cycle
Homo sapiens (human)TUBA1ANP_006000.2
Pan troglodytes (chimpanzee)TUBA1ANP_001092014.1
Macaca mulatta (Rhesus monkey)TUBA1AXP_001108924.2
Canis lupus familiaris (dog)TUBA1AXP_862471.2
Bos taurus (cattle)TUBA1ANP_001159977.1
Mus musculus (house mouse)Tuba1aNP_035783.1
Rattus norvegicus (Norway rat)Tuba1aNP_071634.1
Danio rerio (zebrafish)tuba1l2NP_001177911.1
Drosophila melanogaster (fruit fly)alphaTub84BNP_476772.1
Caenorhabditis elegansmec-12NP_497663.1
GeneCards TUBA1A
UniProt G3V1U9, Q71U36
MIM 602529
Ensembl ENSG00000167552
HGNC 20766
HPRD 03959

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
tubulin alpha-1A chain
tubulin alpha-1A chain
tubulin B-alpha-1
tubulin alpha-3 chain
tubulin, alpha, brain-specific


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