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Sequence in raw or FASTA format:


Blast Method:


RAB7A RAB7A, member RAS oncogene family [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_004637 Homo sapiens RAB7A, member RAS oncogene family (RAB7A), mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 10

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Related Services

Gene Symbol RAB7A
Entrez Gene ID 7879
Full Name RAB7A, member RAS oncogene family
Synonyms PRO2706, RAB7
General protein information
Preferred Names
ras-related protein Rab-7a
ras-related protein Rab-7a
Ras-associated protein RAB7
RAB7, member RAS oncogene family
Gene Type protein-coding
Organism Homo sapiens (human)



Summary RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies. [provided by RefSeq, Jul 2008].

MIM: 602298

Charcot-Marie-Tooth disease, type 2B, 600882 (3)

mRNA Protein Product Sequence Price Select
NM_004637, 40807361 NP_004628, 34147513 ras-related protein Rab-7a ORF Sequence $159.00
hsa05132Salmonella infection
Pathway Interaction Database
il12_2pathwayIL12-mediated signaling events
REACT_6900Immune System
REACT_75774Adaptive Immune System
REACT_121399MHC class II antigen presentation
Homo sapiens (human)RAB7ANP_004628.4
Pan troglodytes (chimpanzee)RAB7AXP_003950230.1
Macaca mulatta (Rhesus monkey)RAB7AXP_001095709.2
Canis lupus familiaris (dog)RAB7ANP_001003316.1
Bos taurus (cattle)RAB7ANP_001030253.1
Mus musculus (house mouse)Rab7NP_033031.2
Rattus norvegicus (Norway rat)Rab7aNP_076440.1
Gallus gallus (chicken)RAB7AXP_003642026.1
Danio rerio (zebrafish)rab7NP_957222.1
Arabidopsis thaliana (thale cress)RAB7BNP_188512.1
Arabidopsis thaliana (thale cress)RABG3ENP_001031161.1
Xenopus (Silurana) tropicalis (western clawed frog)rab7aNP_001008026.1
GO:0006184GTP catabolic processIDA
GO:0006184GTP catabolic processTAS
GO:0006622protein targeting to lysosomeIMP
GO:0007174epidermal growth factor catabolic processIMP
GO:0007264small GTPase mediated signal transductionIEA
GO:0008219cell deathIEA
GO:0008333endosome to lysosome transportIMP
GO:0015031protein transportTAS
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class IITAS
GO:0045022early endosome to late endosome transportIMP
GO:0045453bone resorptionIEA
GO:0090382phagosome maturationTAS
GO:0090383phagosome acidificationIMP
GO:0090385phagosome-lysosome fusionIMP
GO:0005765lysosomal membraneTAS
GO:0005770late endosomeIDA
GO:0005770late endosomeIDA
GO:0005794Golgi apparatusIEA
GO:0030670phagocytic vesicle membraneIEA
GO:0043231intracellular membrane-bounded organelleIDA
GO:0045335phagocytic vesicleIDA
GO:0070062extracellular vesicular exosomeIDA
GO:0097208alveolar lamellar bodyIEA
GO:0003924GTPase activityIDA
GO:0005515protein bindingIPI
GO:0005525GTP bindingIDA
GO:0019003GDP bindingIDA
GO:0048365Rac GTPase bindingIEA
GeneCards RAB7A
PDB 1YHN, 1T91, 3LAW
UniProt P51149
Vega OTTHUMG00000159812
MIM 602298
Ensembl ENSG00000075785
HGNC 9788
HPRD 03805

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the RAB7A gene?

The RAB7A gene provides instructions for making a protein that is involved in endocytosis, a process that brings substances into the cell. During endocytosis, the cell membrane folds around a substance outside the cell (such as a protein) to form a sac-like structure called a vesicle. The vesicle is drawn into the cell and is pinched off from the cell membrane. The RAB7A protein plays a role in vesicle trafficking, which is the movement of these vesicles within the cell.


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