Sequence in raw or FASTA format:
CARD14 caspase recruitment domain family, member 14 [Homo sapiens (human)]
|Entrez Gene ID||79092|
|Full Name||caspase recruitment domain family, member 14|
|Synonyms||BIMP2, CARMA2, PRP, PSORS2, PSS1|
|General protein information||
|Organism||Homo sapiens (human)|
|Summary||This gene encodes a caspase recruitment domain-containing protein that is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. Members of this protein family are scaffold proteins that are involved in a diverse array of cellular processes including cellular adhesion, signal transduction and cell polarity control. This protein has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012].|
|Homo sapiens (human)||CARD14||NP_077015.2|
|Pan troglodytes (chimpanzee)||CARD14||XP_511725.3|
|Macaca mulatta (Rhesus monkey)||CARD14||XP_001110299.1|
|Canis lupus familiaris (dog)||CARD14||XP_540472.3|
|Bos taurus (cattle)||CARD14||NP_001192830.1|
|Mus musculus (house mouse)||Card14||NP_570956.1|
|Rattus norvegicus (Norway rat)||Card14||XP_006248022.1|
|Danio rerio (zebrafish)||card14||XP_697127.4|
|Xenopus (Silurana) tropicalis (western clawed frog)||card14||XP_002937355.2|
|GO:0001934||positive regulation of protein phosphorylation||IDA|
|GO:0007250||activation of NF-kappaB-inducing kinase activity||NAS|
|GO:0033209||tumor necrosis factor-mediated signaling pathway||IMP|
|GO:0043066||negative regulation of apoptotic process||IMP|
|GO:0051092||positive regulation of NF-kappaB transcription factor activity||IMP|
|GO:0050700||CARD domain binding||IPI|
What is the normal function of the CARD14 gene?
The CARD14 gene provides instructions for making a protein that turns on (activates) a group of interacting proteins known as nuclear factor-kappa-B (NF-κB). The NF-κB protein complex regulates the activity of multiple genes, including genes that control the body's immune responses and inflammatory reactions. It also protects cells from certain signals that would otherwise cause them to self-destruct (undergo apoptosis).
The CARD14 protein is found in many of the body's tissues, but it is particularly abundant in the skin. NF-κB signaling appears to play important roles in regulating inflammatory reactions in the skin and in promoting the survival of skin cells.
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