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CARD14 caspase recruitment domain family, member 14 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001257970 Homo sapiens caspase recruitment domain family, member 14 (CARD14), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_024110 Homo sapiens caspase recruitment domain family, member 14 (CARD14), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
NM_052819 Homo sapiens caspase recruitment domain family, member 14 (CARD14), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $699.00 18

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Gene Symbol CARD14
Entrez Gene ID 79092
Full Name caspase recruitment domain family, member 14
Synonyms BIMP2, CARMA2, PRP, PSORS2, PSS1
General protein information
Preferred Names
caspase recruitment domain-containing protein 14
Names
caspase recruitment domain-containing protein 14
carma 2
card-maguk protein 2
CARD-containing MAGUK protein 2
bcl10-interacting maguk protein 2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17q25

Summary This gene encodes a caspase recruitment domain-containing protein that is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. Members of this protein family are scaffold proteins that are involved in a diverse array of cellular processes including cellular adhesion, signal transduction and cell polarity control. This protein has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012].
Disorder

MIM: 607211

mRNA Protein Product Sequence Price Select
NM_001257970, 384229039 NP_001244899, 384229040 caspase recruitment domain-containing protein 14 isoform 3 ORF Sequence $700.00
NM_024110, 384229056 NP_077015, 332801087 caspase recruitment domain-containing protein 14 isoform 1 ORF Sequence $1500.00
NM_052819, 332801088 NP_438170, 16507955 caspase recruitment domain-containing protein 14 isoform 2 ORF Sequence $550.00
Homo sapiens (human)CARD14NP_077015.2
Pan troglodytes (chimpanzee)CARD14XP_511725.3
Macaca mulatta (Rhesus monkey)CARD14XP_001110299.1
Canis lupus familiaris (dog)CARD14XP_540472.3
Bos taurus (cattle)CARD14NP_001192830.1
Mus musculus (house mouse)Card14NP_570956.1
Rattus norvegicus (Norway rat)Card14XP_006248022.1
Danio rerio (zebrafish)card14XP_697127.4
Xenopus (Silurana) tropicalis (western clawed frog)card14XP_002937355.2
Process
IDNameEvidence
GO:0001934positive regulation of protein phosphorylationIDA
GO:0006915apoptotic processIEA
GO:0007250activation of NF-kappaB-inducing kinase activityNAS
GO:0033209tumor necrosis factor-mediated signaling pathwayIMP
GO:0043066negative regulation of apoptotic processIMP
GO:0051092positive regulation of NF-kappaB transcription factor activityIMP
Component
IDNameEvidence
GO:0005737cytoplasmIDA
GO:0005886plasma membraneNAS
Function
IDNameEvidence
GO:0050700CARD domain bindingIPI
GeneCards CARD14
UniProt Q9BXL6
Vega OTTHUMG00000177549
MIM 607211
Ensembl ENSG00000141527
HGNC 16446
HPRD 06235

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the CARD14 gene?

The CARD14 gene provides instructions for making a protein that turns on (activates) a group of interacting proteins known as nuclear factor-kappa-B (NF-κB). The NF-κB protein complex regulates the activity of multiple genes, including genes that control the body's immune responses and inflammatory reactions. It also protects cells from certain signals that would otherwise cause them to self-destruct (undergo apoptosis).

The CARD14 protein is found in many of the body's tissues, but it is particularly abundant in the skin. NF-κB signaling appears to play important roles in regulating inflammatory reactions in the skin and in promoting the survival of skin cells.

Interactant

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