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Sequence in raw or FASTA format:

Database:

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FA2H fatty acid 2-hydroxylase [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu26599 NM_024306 Homo sapiens fatty acid 2-hydroxylase (FA2H), mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu26599C NM_024306 Homo sapiens fatty acid 2-hydroxylase (FA2H), mRNA. Customized vector In-stock 5-7 $149.00

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Gene Symbol FA2H
Entrez Gene ID 79152
Full Name fatty acid 2-hydroxylase
Synonyms FAAH, FAH1, FAXDC1, SCS7, SPG35
General protein information
Preferred Names
fatty acid 2-hydroxylase
Names
fatty acid 2-hydroxylase
fatty acid alpha-hydroxylase
fatty acid hydroxylase domain containing 1
spastic paraplegia 35 (autosomal recessive)
NP_077282.3
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

16

16q23

Summary This gene encodes a protein that catalyzes the synthesis of 2-hydroxysphingolipids, a subset of sphingolipids that contain 2-hydroxy fatty acids. Sphingolipids play roles in many cellular processes and their structural diversity arises from modification of the hydrophobic ceramide moiety, such as by 2-hydroxylation of the N-acyl chain, and the existence of many different head groups. Mutations in this gene have been associated with leukodystrophy dysmyelinating with spastic paraparesis with or without dystonia.[provided by RefSeq, Mar 2010].
Disorder

MIM: 611026

Leukodystrophy, dysmyelinating, and spastic paraparesis with or

mRNA Protein Product Sequence Price Select
NM_024306, 291621627 NP_077282, 205360949 fatty acid 2-hydroxylase ORF Sequence $269.00
Homo sapiens (human)FA2HNP_077282.3
Pan troglodytes (chimpanzee)FA2HXP_511106.3
Macaca mulatta (Rhesus monkey)FA2HXP_001108607.1
Canis lupus familiaris (dog)FA2HXP_853014.1
Bos taurus (cattle)FA2HNP_001179384.1
Mus musculus (house mouse)Fa2hNP_835187.2
Rattus norvegicus (Norway rat)Fa2hNP_001129055.1
Gallus gallus (chicken)FA2HXP_414053.4
Drosophila melanogaster (fruit fly)fa2hNP_610279.3
Caenorhabditis elegansCELE_C25A1.5NP_492678.1
Arabidopsis thaliana (thale cress)FAH1NP_181023.1
Xenopus (Silurana) tropicalis (western clawed frog)fa2hNP_001025677.1
Process
IDNameEvidence
GO:0001949sebaceous gland cell differentiationIEA
GO:0006633fatty acid biosynthetic processIEA
GO:0006665sphingolipid metabolic processIEA
GO:0008219cell deathIEA
GO:0030258lipid modificationIEA
GO:0032286central nervous system myelin maintenanceIEA
GO:0032287peripheral nervous system myelin maintenanceIEA
GO:0042127regulation of cell proliferationIEA
GO:0042634regulation of hair cycleIEA
GO:0055114oxidation-reduction processIEA
Component
IDNameEvidence
GO:0005789endoplasmic reticulum membraneIEA
GO:0016021integral component of membraneIEA
Function
IDNameEvidence
GO:0005506iron ion bindingIEA
GO:0020037heme bindingIEA
GO:0080132fatty acid alpha-hydroxylase activityIEA
GeneCards FA2H
UniProt Q7L5A8
Vega OTTHUMG00000137603
MIM 611026
Ensembl ENSG00000103089
HGNC 21197
HPRD 16873

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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