MMEL1 membrane metallo-endopeptidase-like 1 [Homo sapiens (human)]
| Gene Symbol | MMEL1 |
| Entrez Gene ID | 79258 |
| Full Name | membrane metallo-endopeptidase-like 1 |
| Synonyms | MGC119454, MGC119455, MGC119456, MMEL2, NEP2, NEPII, NL1, NL2, SEP |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
1 1p36 |
| Summary | The protein encoded by this gene is a member of the neutral endopeptidase (NEP) or membrane metallo-endopeptidase (MME) family. Family members play important roles in pain perception, arterial pressure regulation, phosphate metabolism and homeostasis. This protein is a type II transmembrane protein and is thought to be expressed as a secreted protein. This gene is expressed mainly in testis with weak expression in the brain, kidney, and heart. [provided by RefSeq]. |
| Disorder | MIM: |
| mRNA | NM_033467, 239049390 |
| Protein | NP_258428, 239049391 |
| Product | membrane metallo-endopeptidase-like 1 |
| RefSeq Status | REVIEWED |
| Homo sapiens (human) | MMEL1 | NP_258428.2 |
| Pan troglodytes (chimpanzee) | MMEL1 | XP_001150860.1 |
| Canis lupus familiaris (dog) | MMEL1 | XP_546737.2 |
| Bos taurus (cattle) | MMEL1 | XP_874253.3 |
| Mus musculus (house mouse) | Mmel1 | NP_038811.1 |
| Rattus norvegicus (Norway rat) | Mmel1 | XP_233712.4 |
| Gallus gallus (chicken) | MMEL1 | XP_001233077.1 |
| Danio rerio (zebrafish) | LOC560703 | XP_689191.2 |
| Drosophila melanogaster (fruit fly) | Nep4 | NP_650904.3 |
| ID | Name | Evidence |
| GO:0006508 | proteolysis | IEA |
Component
| ID | Name | Evidence |
| GO:0005576 | extracellular region | IEA |
| GO:0016020 | membrane | IEA |
| GO:0016021 | integral to membrane | IEA |
| GO:0043231 | intracellular membrane-bounded organelle | IDA |
Function
| ID | Name | Evidence |
| GO:0004222 | metalloendopeptidase activity | IEA |
| GO:0008233 | peptidase activity | IEA |
| GO:0046872 | metal ion binding | IEA |
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