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Sequence in raw or FASTA format:


Blast Method:


PALB2 partner and localizer of BRCA2 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_024675 Homo sapiens partner and localizer of BRCA2 (PALB2), mRNA. GenEZ ORF Cloning On-demand $1699.00 25

*Business Day

Related Services

Gene Symbol PALB2
Entrez Gene ID 79728
Full Name partner and localizer of BRCA2
Synonyms FANCN, PNCA3
General protein information
Preferred Names
partner and localizer of BRCA2
partner and localizer of BRCA2
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2. [provided by RefSeq, Jul 2008].

MIM: 610355

Fanconi anemia, complementation group N, 610832 (3); {Breast cancer,

mRNA Protein Product Sequence Price Select
NM_024675, 113722109 NP_078951, 27436910 partner and localizer of BRCA2 ORF Sequence $1500.00
hsa03460Fanconi anemia pathway
REACT_18410Fanconi Anemia pathway
REACT_216DNA Repair
Homo sapiens (human)PALB2NP_078951.2
Pan troglodytes (chimpanzee)PALB2XP_510877.2
Macaca mulatta (Rhesus monkey)PALB2XP_001095569.2
Canis lupus familiaris (dog)PALB2XP_850671.2
Bos taurus (cattle)PALB2NP_001192544.1
Mus musculus (house mouse)Palb2NP_001074707.1
Rattus norvegicus (Norway rat)Palb2NP_001178532.1
Gallus gallus (chicken)PALB2XP_004945321.1
GO:0000724double-strand break repair via homologous recombinationIDA
GO:0001833inner cell mass cell proliferationIEA
GO:0006281DNA repairTAS
GO:0007498mesoderm developmentIEA
GO:0009887organ morphogenesisIEA
GO:0036342post-anal tail morphogenesisIEA
GO:0043066negative regulation of apoptotic processIEA
GO:0003677DNA bindingIDA
GO:0005515protein bindingIPI
GeneCards PALB2
PDB 2W18, 3EU7
UniProt Q86YC2
Vega OTTHUMG00000177097
MIM 610355
Ensembl ENSG00000083093
HGNC 26144
HPRD 07966

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the PALB2 gene?

The PALB2 gene provides instructions for making a protein called partner and localizer of BRCA2. As its name suggests, this protein interacts with the protein produced from the BRCA2 gene. These two proteins work together to mend broken strands of DNA, which prevents cells from accumulating genetic damage that can trigger them to divide uncontrollably. Because the PALB2 and BRCA2 proteins help control the rate of cell growth and division, they are described as tumor suppressors.

The PALB2 protein stabilizes the BRCA2 protein and anchors it to structures within the nucleus, allowing the BRCA2 protein to fix damaged DNA. Breaks in DNA can be caused by natural and medical radiation or other environmental exposures, and also occur when chromosomes exchange genetic material in preparation for cell division. By helping repair mistakes in DNA, the PALB2 and BRCA2 proteins play a critical role in maintaining the stability of a cell's genetic information.


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