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PDZD3 PDZ domain containing 3 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001168468 Homo sapiens PDZ domain containing 3 (PDZD3), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_024791 Homo sapiens PDZ domain containing 3 (PDZD3), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_005271678 PREDICTED: Homo sapiens PDZ domain containing 3 (PDZD3), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $549.00 14
XM_006718914 PREDICTED: Homo sapiens PDZ domain containing 3 (PDZD3), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand $449.00 14

*Business Day

Related Services

Gene Symbol PDZD3
Entrez Gene ID 79849
Full Name PDZ domain containing 3
Synonyms IKEPP, NHERF4, PDZK2
General protein information
Preferred Names
Na(+)/H(+) exchange regulatory cofactor NHE-RF4
Names
Na(+)/H(+) exchange regulatory cofactor NHE-RF4
NHERF-4
naPi-Cap2
PDZ domain containing 2
PDZ domain-containing protein 2
PDZ domain-containing protein 3
intestinal and kidney enriched PDZ protein
intestinal and kidney-enriched PDZ protein
sodium-hydrogen exchanger regulatory factor 4
na/Pi cotransporter C-terminal-associated protein 2
natrium-phosphate cotransporter IIa C-terminal-associated protein 2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11q23.3

Summary Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR; MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 [PubMed 11950846]).[supplied by OMIM, Mar 2008].
Disorder

MIM: 607146

mRNA Protein Product Sequence Price Select
NM_001168468, 270483763 NP_001161940, 270483764 Na(+)/H(+) exchange regulatory cofactor NHE-RF4 isoform 1 ORF Sequence $550.00
NM_024791, 270483750 NP_079067, 270483751 Na(+)/H(+) exchange regulatory cofactor NHE-RF4 isoform 2 ORF Sequence $550.00
XM_005271678, 578822394 XP_005271735, 530398388 Na(+)/H(+) exchange regulatory cofactor NHE-RF4 isoform X2 ORF Sequence $400.00
XM_006718914, 578822395 XP_006718977, 578822396 Na(+)/H(+) exchange regulatory cofactor NHE-RF4 isoform X3 ORF Sequence $300.00
Homo sapiens (human)PDZD3NP_001161940.1
Pan troglodytes (chimpanzee)PDZD3XP_522203.1
Macaca mulatta (Rhesus monkey)PDZD3XP_001104508.1
Canis lupus familiaris (dog)PDZD3XP_853212.2
Bos taurus (cattle)PDZD3NP_001029836.1
Mus musculus (house mouse)Pdzd3NP_573489.2
Rattus norvegicus (Norway rat)Pdzd3NP_001178925.1
Gallus gallus (chicken)PDZD3XP_001233191.3
Danio rerio (zebrafish)pdzd3bNP_001124259.1
Danio rerio (zebrafish)pdzd3aXP_685398.3
Xenopus (Silurana) tropicalis (western clawed frog)pdzd3XP_002935063.2
Process
IDNameEvidence
GO:0006811ion transportNAS
GO:0006833water transportNAS
GO:0007168receptor guanylyl cyclase signaling pathwayIC
GO:0009636response to toxic substanceTAS
GO:0019934cGMP-mediated signalingNAS
GO:0030827negative regulation of cGMP biosynthetic processTAS
GO:0031283negative regulation of guanylate cyclase activityIDA
Component
IDNameEvidence
GO:0005829cytosolTAS
GO:0005903brush borderIDA
GO:0035003subapical complexIDA
GO:0045177apical part of cellIDA
Function
IDNameEvidence
GO:0005515protein bindingIPI
GO:0008022protein C-terminus bindingIPI
GO:0008200ion channel inhibitor activityTAS
GO:0030251guanylate cyclase inhibitor activityIDA
GeneCards PDZD3
UniProt B0YJ61, Q86UT5
Vega OTTHUMG00000166224
MIM 607146
Ensembl ENSG00000172367
HGNC 19891
HPRD 06191

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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