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PDZD3 PDZ domain containing 3 [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_001168468 Homo sapiens PDZ domain containing 3 (PDZD3), transcript variant 1, mRNA. ORF Sequence $440.22
Peptide Services
Antibody Services
Protein Services
NM_024791 Homo sapiens PDZ domain containing 3 (PDZD3), transcript variant 2, mRNA. ORF Sequence $428.04
Peptide Services
Antibody Services
Protein Services


Gene Symbol PDZD3
Entrez Gene ID 79849
Full Name PDZ domain containing 3
Synonyms FLJ22756, IKEPP, NHERF4, PDZK2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11q23.3

Summary Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR; MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 [PubMed 11950846]).[supplied by OMIM, Mar 2008].
Disorder

MIM: 607146

mRNA Protein Product Sequence Price Select
NM_001168468, 270483763 NP_001161940, 270483764 Na(+)/H(+) exchange regulatory cofactor NHE-RF4 isoform 1 Full Length $663.23
ORF Sequence $440.22
NM_024791, 270483750 NP_079067, 270483751 Na(+)/H(+) exchange regulatory cofactor NHE-RF4 isoform 2 Full Length $651.05
ORF Sequence $428.04
Homo sapiens (human)PDZD3NP_001161940.1
Pan troglodytes (chimpanzee)PDZD3XP_522203.1
Macaca mulatta (Rhesus monkey)PDZD3XP_001104508.1
Canis lupus familiaris (dog)PDZD3XP_853212.2
Bos taurus (cattle)PDZD3NP_001029836.1
Mus musculus (house mouse)Pdzd3NP_573489.2
Rattus norvegicus (Norway rat)Pdzd3XP_576397.2
Gallus gallus (chicken)PDZD3XP_001233191.2
GeneCards PDZD3
PDB 2V90
UniProt B0YJ61, Q86UT5
MIM 607146
Ensembl ENSG00000172367
HGNC 19891
HPRD 06191

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
Na(+)/H(+) exchange regulatory cofactor NHE-RF4
Names
Na(+)/H(+) exchange regulatory cofactor NHE-RF4
NHERF-4
naPi-Cap2
PDZ domain containing 2
PDZ domain-containing protein 2
PDZ domain-containing protein 3
intestinal and kidney enriched PDZ protein
intestinal and kidney-enriched PDZ protein
sodium-hydrogen exchanger regulatory factor 4
na/Pi cotransporter C-terminal-associated protein 2
natrium-phosphate cotransporter IIa C-terminal-associated protein 2

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