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Blast Method:


CUBN cubilin (intrinsic factor-cobalamin receptor) [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001081 Homo sapiens cubilin (intrinsic factor-cobalamin receptor) (CUBN), mRNA. GenEZ ORF Cloning On-demand TBD TBD

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Gene Symbol CUBN
Entrez Gene ID 8029
Full Name cubilin (intrinsic factor-cobalamin receptor)
Synonyms IFCR, MGA1, gp280
General protein information
Preferred Names
460 kDa receptor
cubilin precursor variant 1
cubilin precursor variant 2
intestinal intrinsic factor receptor
intrinsic factor-vitamin B12 receptor
Gene Type protein-coding
Organism Homo sapiens (human)



Summary Cubilin (CUBN) acts as a receptor for intrinsic factor-vitamin B12 complexes. The role of receptor is supported by the presence of 27 CUB domains. Cubulin is located within the epithelium of intestine and kidney. Mutations in CUBN may play a role in autosomal recessive megaloblastic anemia. [provided by RefSeq, Jul 2008].

MIM: 602997

Megaloblastic anemia-1, Finnish type, 261100 (3)

mRNA Protein Product Sequence Price Select
NM_001081, 126091151 NP_001072, 126091152 cubilin precursor ORF Sequence $-1.00
hsa04977Vitamin digestion and absorption
REACT_13621HDL-mediated lipid transport
REACT_602Lipid digestion, mobilization, and transport
REACT_11057Metabolism of steroid hormones and vitamin D
REACT_6823Lipoprotein metabolism
REACT_11238Metabolism of water-soluble vitamins and cofactors
REACT_11193Metabolism of vitamins and cofactors
REACT_13523Vitamin D (calciferol) metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_163862Cobalamin (Cbl, vitamin B12) transport and metabolism
REACT_169132Defective CUBN causes hereditary megaloblastic anemia 1
REACT_169429Defects in cobalamin (B12) metabolism
REACT_169169Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC
REACT_169256Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD
REACT_169120Defective TCN2 causes hereditary megaloblastic anemia
REACT_169318Defective MMAB causes methylmalonic aciduria type cblB
REACT_169415Defective GIF causes intrinsic factor deficiency
REACT_169439Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE
REACT_169280Defective AMN causes hereditary megaloblastic anemia 1
REACT_169313Defective MUT causes methylmalonic aciduria mut type
REACT_169312Defective HLCS causes multiple carboxylase deficiency
REACT_169363Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF
REACT_169149Defective MTR causes methylmalonic aciduria and homocystinuria type cblG
REACT_169316Defective MMAA causes methylmalonic aciduria type cblA
REACT_169178Defective CD320 causes methylmalonic aciduria
REACT_169385Defects in vitamin and cofactor metabolism
REACT_169238Defects in biotin (Btn) metabolism
REACT_169403Defective BTD causes biotidinase deficiency
Homo sapiens (human)CUBNNP_001072.2
Canis lupus familiaris (dog)CUBNNP_001003148.1
Bos taurus (cattle)CUBNNP_001179504.1
Mus musculus (house mouse)CubnNP_001074553.1
Rattus norvegicus (Norway rat)CubnNP_445784.1
Gallus gallus (chicken)CUBNXP_001235156.3
Danio rerio (zebrafish)cubnXP_002666724.2
Drosophila melanogaster (fruit fly)CG32702NP_727348.2
Caenorhabditis elegansZC116.3NP_506157.3
Xenopus (Silurana) tropicalis (western clawed frog)cubnXP_002939051.2
GO:0001894tissue homeostasisNAS
GO:0006766vitamin metabolic processTAS
GO:0006767water-soluble vitamin metabolic processTAS
GO:0006898receptor-mediated endocytosisNAS
GO:0008202steroid metabolic processTAS
GO:0008203cholesterol metabolic processIEA
GO:0009235cobalamin metabolic processTAS
GO:0015889cobalamin transportTAS
GO:0042157lipoprotein metabolic processTAS
GO:0042359vitamin D metabolic processTAS
GO:0042953lipoprotein transportIEA
GO:0044281small molecule metabolic processTAS
GO:0005765lysosomal membraneIEA
GO:0005783endoplasmic reticulumIEA
GO:0005794Golgi apparatusIEA
GO:0005886plasma membraneTAS
GO:0005905coated pitIEA
GO:0010008endosome membraneTAS
GO:0016324apical plasma membraneIDA
GO:0030139endocytic vesicleIDA
GO:0031232extrinsic component of external side of plasma membraneNAS
GO:0031526brush border membraneNAS
GO:0043202lysosomal lumenTAS
GO:0070062extracellular vesicular exosomeIDA
GO:0004872receptor activityIEA
GO:0005215transporter activityTAS
GO:0005509calcium ion bindingIEA
GO:0005515protein bindingIPI
GO:0031419cobalamin bindingIEA
GO:0042803protein homodimerization activityIDA
GeneCards CUBN
UniProt O60494
Vega OTTHUMG00000017741
MIM 602997
Ensembl ENSG00000107611
HGNC 2548
HPRD 04296

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the CUBN gene?

The CUBN gene provides instructions for making a protein called cubilin. This protein is involved in the uptake of vitamin B12 (also called cobalamin) from food into the body. Vitamin B12, which cannot be made in the body and can only be obtained from food, is essential for the formation of DNA and proteins, the production of cellular energy, and the breakdown of fats. This vitamin is involved in the formation of red blood cells and maintenance of the brain and spinal cord (central nervous system).

The cubilin protein is primarily found associated with kidney cells and cells that line the small intestine. Cubilin is anchored to the outer membrane of these cells by its attachment to another protein called amnionless. Cubilin can interact with molecules and proteins passing through the small intestine and kidneys, including vitamin B12. During digestion, vitamin B12 is released from food. As the vitamin passes through the small intestine, cubilin attaches (binds) to it. Amnionless helps transfer the cubilin-vitamin B12 complex into the intestinal cell. From there, the vitamin is released into the blood and transported throughout the body. In the kidneys, cubilin and amnionless are involved in the reabsorption of certain proteins that would otherwise be released in urine.


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