Sequence in raw or FASTA format:
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 [Homo sapiens (human)]
|Entrez Gene ID||80331|
|Full Name||DnaJ (Hsp40) homolog, subfamily C, member 5|
|Synonyms||CLN4, CLN4B, CSP, DNAJC5A, NCL|
|General protein information||
|Organism||Homo sapiens (human)|
|Summary||This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins. The encoded protein plays a role in membrane trafficking and protein folding, and has been shown to have anti-neurodegenerative properties. The encoded protein is known to play a role in cystic fibrosis and Huntington's disease. A pseudogene of this gene is located on the short arm of chromosome 8. [provided by RefSeq, Nov 2010].|
|hsa04141||Protein processing in endoplasmic reticulum|
|REACT_13723||Neurotransmitter Release Cycle|
|REACT_13477||Transmission across Chemical Synapses|
|REACT_23947||GABA synthesis, release, reuptake and degradation|
|Homo sapiens (human)||DNAJC5||NP_079495.1|
|Pan troglodytes (chimpanzee)||DNAJC5||XP_530321.2|
|Macaca mulatta (Rhesus monkey)||DNAJC5||XP_001084014.1|
|Canis lupus familiaris (dog)||DNAJC5||XP_005635371.1|
|Bos taurus (cattle)||DNAJC5||NP_776958.2|
|Mus musculus (house mouse)||Dnajc5||NP_058055.1|
|Rattus norvegicus (Norway rat)||Dnajc5||NP_077075.1|
|Gallus gallus (chicken)||DNAJC5||NP_001264937.1|
|Danio rerio (zebrafish)||dnajc5aa||NP_001002464.1|
|Danio rerio (zebrafish)||dnajc5ab||XP_001338363.1|
|Drosophila melanogaster (fruit fly)||Csp||NP_524213.1|
|GO:0043524||negative regulation of neuron apoptotic process||IEA|
|GO:0061202||clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane||TAS|
|GO:0070062||extracellular vesicular exosome||IDA|
|GO:0043008||ATP-dependent protein binding||IEA|
What is the normal function of the DNAJC5 gene?
The DNAJC5 provides instructions for making a protein called cysteine string protein alpha (CSPα). This protein is found in the brain, where it plays a role in the transmission of nerve impulses. CSPα helps sac-like structures called synaptic vesicles attach to nerve cells. Synaptic vesicles contain chemical messengers that transmit signals from one nerve cell to another.
Researchers suspect that CSPα may also help repair proteins that are involved in the transmission of nerve impulses by re-folding any that have the incorrect 3-dimensional shape.
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