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SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_030777 Homo sapiens solute carrier family 2 (facilitated glucose transporter), member 10 (SLC2A10), mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_006723879 PREDICTED: Homo sapiens solute carrier family 2 (facilitated glucose transporter), member 10 (SLC2A10), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_006723880 PREDICTED: Homo sapiens solute carrier family 2 (facilitated glucose transporter), member 10 (SLC2A10), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $699.00 18

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Related Services

Gene Symbol SLC2A10
Entrez Gene ID 81031
Full Name solute carrier family 2 (facilitated glucose transporter), member 10
Synonyms ATS, GLUT10
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

20

20q13.1

Summary This gene encodes a member of the class III facilitative glucose transporter family. The encoded protein plays a role in regulation of glucose homeostasis. Mutations in this gene have been associated with arterial tortuosity syndrome.[provided by RefSeq, Dec 2009].
Disorder

MIM: 606145

Arterial tortuosity syndrome, 208050 (3)

mRNA Protein Product Sequence Price Select
NM_030777, 39777591 NP_110404, 13540547 solute carrier family 2, facilitated glucose transporter member 10 ORF Sequence $550.00
XM_006723879, 578836202 XP_006723942, 578836203 solute carrier family 2, facilitated glucose transporter member 10 isoform X1 ORF Sequence $550.00
XM_006723880, 578836205 XP_006723943, 578836206 solute carrier family 2, facilitated glucose transporter member 10 isoform X2 ORF Sequence $550.00
Reactome
REACT_19118SLC-mediated transmembrane transport
REACT_19305Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
REACT_19343Facilitative Na+-independent glucose transporters
REACT_15518Transmembrane transport of small molecules
Homo sapiens (human)SLC2A10NP_110404.1
Pan troglodytes (chimpanzee)SLC2A10XP_003317028.1
Macaca mulatta (Rhesus monkey)SLC2A10XP_001107356.2
Canis lupus familiaris (dog)SLC2A10XP_005635193.1
Bos taurus (cattle)SLC2A10NP_001179368.1
Mus musculus (house mouse)Slc2a10NP_569718.1
Rattus norvegicus (Norway rat)Slc2a10NP_001102433.1
Gallus gallus (chicken)SLC2A10XP_417383.3
Danio rerio (zebrafish)slc2a10NP_001104633.1
Xenopus (Silurana) tropicalis (western clawed frog)slc2a10NP_001072926.1
Process
IDNameEvidence
GO:0015758glucose transportNAS
GO:0015992proton transportNAS
GO:0055085transmembrane transportTAS
Component
IDNameEvidence
GO:0005737cytoplasmIDA
GO:0005886plasma membraneTAS
GO:0012505endomembrane systemIEA
GO:0016021integral component of membraneNAS
GO:0048471perinuclear region of cytoplasmIEA
Function
IDNameEvidence
GO:0005351sugar:proton symporter activityNAS
GeneCards SLC2A10
UniProt O95528
Vega OTTHUMG00000032657
MIM 606145
Ensembl ENSG00000197496
HGNC 13444
HPRD 05851

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the SLC2A10 gene?

The SLC2A10 gene provides instructions for making a protein called GLUT10. GLUT10 is classified as a glucose transporter; this type of protein moves the simple sugar glucose across cell membranes and helps maintain proper levels of glucose within cells. However, GLUT10 has some structural differences from other glucose transporters, and its role in the movement of glucose or other substances is unclear.

The level of GLUT10 appears to be involved in the regulation of a process called the transforming growth factor-beta (TGF-β) signaling pathway. This pathway is involved in cell growth and division (proliferation) and the process by which cells mature to carry out special functions (differentiation). The TGF-β signaling pathway is also involved in bone and blood vessel development and the formation of the extracellular matrix, an intricate lattice of proteins and other molecules that forms in the spaces between cells and defines the structure and properties of connective tissues. Connective tissue provides strength and flexibility to structures throughout the body, including blood vessels, skin, joints, and the gastrointestinal tract.

Studies indicate that GLUT10 may also be involved in the functioning of mitochondria, the energy-producing centers within cells.

Interactant

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