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CAMK2A calcium/calmodulin-dependent protein kinase II alpha [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu15670 NM_015981 Homo sapiens calcium/calmodulin-dependent protein kinase II alpha (CAMK2A), transcript variant 1, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu15931 NM_171825 Homo sapiens calcium/calmodulin-dependent protein kinase II alpha (CAMK2A), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu15670C NM_015981 Homo sapiens calcium/calmodulin-dependent protein kinase II alpha (CAMK2A), transcript variant 1, mRNA. Customized vector In-stock 5-7 $149.00
OHu15931C NM_171825 Homo sapiens calcium/calmodulin-dependent protein kinase II alpha (CAMK2A), transcript variant 2, mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol CAMK2A
Entrez Gene ID 815
Full Name calcium/calmodulin-dependent protein kinase II alpha
Synonyms CAMKA
General protein information
Preferred Names
calcium/calmodulin-dependent protein kinase type II subunit alpha
Names
calcium/calmodulin-dependent protein kinase type II subunit alpha
CaMKIINalpha
CaMK-II alpha subunit
caMK-II subunit alpha
CaM-kinase II alpha chain
CaM kinase II alpha subunit
caM kinase II subunit alpha
calcium/calmodulin-dependent protein kinase II alpha-B subunit
calcium/calmodulin-dependent protein kinase type II alpha chain
calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha
NP_057065.2
NP_741960.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q32

Summary The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008].
Disorder

MIM: 114078

mRNA Protein Product Sequence Price Select
NM_015981, 212549564 NP_057065, 25952114 calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 1 ORF Sequence $360.00
NM_171825, 212549565 NP_741960, 25952118 calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 2 ORF Sequence $550.00
KEGG
hsa04012ErbB signaling pathway
hsa04020Calcium signaling pathway
hsa04310Wnt signaling pathway
hsa04720Long-term potentiation
hsa04916Melanogenesis
hsa04740Olfactory transduction
hsa04912GnRH signaling pathway
hsa05214Glioma
hsa04722Neurotrophin signaling pathway
hsa04114Oocyte meiosis
hsa04971Gastric acid secretion
hsa05152Tuberculosis
hsa04725Cholinergic synapse
hsa04728Dopaminergic synapse
hsa04066HIF-1 signaling pathway
hsa05205Proteoglycans in cancer
hsa04713Circadian entrainment
hsa05031Amphetamine addiction
hsa04261Adrenergic signaling in cardiomyocytes
hsa04911Insulin secretion
hsa04750Inflammatory mediator regulation of TRP channels
hsa04921Oxytocin signaling pathway
WikiPathways
WP437EGFR1 Signaling Pathway
WP289Myometrial Relaxation and Contraction Pathways
WP366TGF-beta Receptor Signaling Pathway
WP363Wnt Signaling Pathway NetPath
WP673ErbB signaling pathway
WP536Calcium Regulation in the Cardiac Cell
WP2377Integrated Pancreatic Cancer Pathway
WP2380BDNF signaling pathway
WP2355Corticotropin-releasing hormone
Pathway Interaction Database
fgf_pathwayFGF signaling pathway
pi3kplctrkpathwayTrk receptor signaling mediated by PI3K and PLC-gamma
tgfbrpathwayTGF-beta receptor signaling
ifngpathwayIFN-gamma pathway
wnt_noncanonical_pathwayNoncanonical Wnt signaling pathway
Reactome
REACT_6900Immune System
REACT_11045Signaling by Wnt
REACT_15370Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
REACT_18307Trafficking of AMPA receptors
REACT_13477Transmission across Chemical Synapses
REACT_18347Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
REACT_13685Neuronal System
REACT_20594Unblocking of NMDA receptor, glutamate binding and activation
REACT_20568CREB phosphorylation through the activation of Ras
REACT_20563Activation of NMDA receptor upon glutamate binding and postsynaptic events
REACT_20546Ras activation uopn Ca2+ infux through NMDA receptor
REACT_20593Post NMDA receptor activation events
REACT_20642CREB phosphorylation through the activation of CaMKII
REACT_75790Cytokine Signaling in Immune system
REACT_25229Interferon Signaling
REACT_25078Interferon gamma signaling
REACT_111102Signal Transduction
REACT_120956Cellular responses to stress
REACT_200819Cellular response to heat stress
REACT_200775HSF1-dependent transactivation
REACT_172761Ca2+ pathway
REACT_172694beta-catenin independent WNT signaling
Homo sapiens (human)CAMK2ANP_057065.2
Pan troglodytes (chimpanzee)CAMK2AXP_001165329.2
Canis lupus familiaris (dog)CAMK2AXP_005619357.1
Bos taurus (cattle)CAMK2ANP_001069406.1
Mus musculus (house mouse)Camk2aNP_803126.1
Rattus norvegicus (Norway rat)Camk2aNP_037052.1
Gallus gallus (chicken)CAMK2ANP_989626.1
Danio rerio (zebrafish)camk2aNP_001017741.2
Xenopus (Silurana) tropicalis (western clawed frog)camk2aNP_001093737.1
Process
IDNameEvidence
GO:0000082G1/S transition of mitotic cell cycleIEA
GO:0006468protein phosphorylationIDA
GO:0006816calcium ion transportIEA
GO:0007268synaptic transmissionTAS
GO:0019221cytokine-mediated signaling pathwayTAS
GO:0046777protein autophosphorylationIEA
GO:0046928regulation of neurotransmitter secretionIEA
GO:0048168regulation of neuronal synaptic plasticityIEA
GO:0051092positive regulation of NF-kappaB transcription factor activityIMP
GO:0060333interferon-gamma-mediated signaling pathwayTAS
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005654nucleoplasmTAS
GO:0005829cytosolTAS
GO:0005886plasma membraneTAS
GO:0030054cell junctionIEA
GO:0030666endocytic vesicle membraneTAS
GO:0042734presynaptic membraneIEA
Function
IDNameEvidence
GO:0004683calmodulin-dependent protein kinase activityIEA
GO:0005515protein bindingIPI
GO:0005516calmodulin bindingIEA
GO:0005524ATP bindingIEA
GO:0016301kinase activityIDA
GO:0035254glutamate receptor bindingIEA
GeneCards CAMK2A
UniProt Q7LDD5, Q9UQM7, Q8IWE0, A8K161
Vega OTTHUMG00000134281
MIM 114078
Ensembl ENSG00000070808
HGNC 1460
HPRD 06532

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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