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CAMK2A calcium/calmodulin-dependent protein kinase II alpha [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_015981 Homo sapiens calcium/calmodulin-dependent protein kinase II alpha (CAMK2A), transcript variant 1, mRNA. ORF Sequence $426.30
Peptide Services
Antibody Services
Protein Services
NM_171825 Homo sapiens calcium/calmodulin-dependent protein kinase II alpha (CAMK2A), transcript variant 2, mRNA. ORF Sequence $416.73
Peptide Services
Antibody Services
Protein Services


Gene Symbol CAMK2A
Entrez Gene ID 815
Full Name calcium/calmodulin-dependent protein kinase II alpha
Synonyms CAMKA, KIAA0968
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q32

Summary The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008].
Disorder

MIM: 114078

mRNA Protein Product Sequence Price Select
NM_015981, 212549564 NP_057065, 25952114 calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 1 Full Length $1721.30
ORF Sequence $426.30
NM_171825, 212549565 NP_741960, 25952118 calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 2 Full Length $1709.75
ORF Sequence $416.73
KEGG
hsa04012ErbB signaling pathway
hsa04114Oocyte meiosis
hsa04912GnRH signaling pathway
hsa04740Olfactory transduction
hsa04725Cholinergic synapse
hsa04728Dopaminergic synapse
hsa05031Amphetamine addiction
hsa05152Tuberculosis
hsa04971Gastric acid secretion
hsa04066HIF-1 signaling pathway
hsa04020Calcium signaling pathway
hsa05214Glioma
hsa04916Melanogenesis
hsa04713Circadian entrainment
hsa04720Long-term potentiation
hsa04310Wnt signaling pathway
hsa04722Neurotrophin signaling pathway
Pathway Interaction Database
ifngpathwayIFN-gamma pathway
fgf_pathwayFGF signaling pathway
tgfbrpathwayTGF-beta receptor signaling
pi3kplctrkpathwayTrk receptor signaling mediated by PI3K and PLC-gamma
wnt_noncanonical_pathwayNoncanonical Wnt signaling pathway
WikiPathways
WP2256Integrated Pancreatic Cancer Pathway
WP366TGF-beta Receptor Signaling Pathway
WP437EGFR1 Signaling Pathway
WP2377Integrated Pancreatic Cancer Pathway
WP289Myometrial Relaxation and Contraction Pathways
WP536Calcium Regulation in the Cardiac Cell
WP363Wnt Signaling Pathway NetPath
WP673ErbB signaling pathway
Reactome
REACT_6900Immune System
REACT_20546Ras activation uopn Ca2+ infux through NMDA receptor
REACT_18307Trafficking of AMPA receptors
REACT_20593Post NMDA receptor activation events
REACT_20568CREB phosphorylation through the activation of Ras
REACT_13685Neuronal System
REACT_18347Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
REACT_20642CREB phosphorylation through the activation of CaMKII
REACT_25229Interferon Signaling
REACT_20563Activation of NMDA receptor upon glutamate binding and postsynaptic events
REACT_20594Unblocking of NMDA receptor, glutamate binding and activation
REACT_75790Cytokine Signaling in Immune system
REACT_13477Transmission across Chemical Synapses
REACT_25078Interferon gamma signaling
REACT_15370Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Homo sapiens (human)CAMK2ANP_057065.2
Pan troglodytes (chimpanzee)CAMK2AXP_001165329.2
Canis lupus familiaris (dog)CAMK2AXP_853581.1
Bos taurus (cattle)CAMK2ANP_001069406.1
Mus musculus (house mouse)Camk2aNP_803126.1
Rattus norvegicus (Norway rat)Camk2aNP_037052.1
Gallus gallus (chicken)CAMK2ANP_989626.1
Danio rerio (zebrafish)camk2aNP_001017741.2
Arabidopsis thaliana (thale cress)CPK29NP_974150.2
GeneCards CAMK2A
PDB 3SOA, 2VZ6
UniProt Q7LDD5, Q9UQM7, Q8IWE0, A8K161
MIM 114078
Ensembl ENSG00000070808
HGNC 1460
HPRD 06532

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
calcium/calmodulin-dependent protein kinase type II subunit alpha
Names
calcium/calmodulin-dependent protein kinase type II subunit alpha
CaMKIINalpha
CaMK-II alpha subunit
caMK-II subunit alpha
CaM-kinase II alpha chain
CaM kinase II alpha subunit
caM kinase II subunit alpha
calcium/calmodulin-dependent protein kinase II alpha-B subunit
calcium/calmodulin-dependent protein kinase type II alpha chain
calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha
NP_057065.2
NP_741960.1

Interactant

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