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FIP1L1 FIP1 like 1 (S. cerevisiae) [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001134937 Homo sapiens FIP1 like 1 (S. cerevisiae) (FIP1L1), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_001134938 Homo sapiens FIP1 like 1 (S. cerevisiae) (FIP1L1), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_030917 Homo sapiens FIP1 like 1 (S. cerevisiae) (FIP1L1), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $849.00 20

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Gene Symbol FIP1L1
Entrez Gene ID 81608
Full Name FIP1 like 1 (S. cerevisiae)
Synonyms DKFZp586K0717, FLJ33619, Rhe, hFip1
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008].

MIM: 607686

mRNA Protein Product Sequence Price Select
NM_001134937, 201023338 NP_001128409, 201023339 pre-mRNA 3'-end-processing factor FIP1 isoform 2 ORF Sequence $700.00
NM_001134938, 201023340 NP_001128410, 201023341 pre-mRNA 3'-end-processing factor FIP1 isoform 3 ORF Sequence $550.00
NM_030917, 201023337 NP_112179, 40254978 pre-mRNA 3'-end-processing factor FIP1 isoform 1 ORF Sequence $700.00
hsa03015mRNA surveillance pathway
Homo sapiens (human)FIP1L1NP_001128410.1
Pan troglodytes (chimpanzee)FIP1L1XP_001146744.2
Macaca mulatta (Rhesus monkey)FIP1L1XP_001089880.2
Canis lupus familiaris (dog)FIP1L1XP_853955.2
Bos taurus (cattle)FIP1L1NP_001193619.1
Mus musculus (house mouse)Fip1l1NP_077145.2
Rattus norvegicus (Norway rat)Fip1l1NP_001008296.1
Gallus gallus (chicken)FIP1L1XP_001233386.2
Danio rerio (zebrafish)fip1l1bNP_001006042.1
Drosophila melanogaster (fruit fly)Fip1NP_649476.1
Caenorhabditis elegansfipp-1NP_504203.1
GeneCards FIP1L1
UniProt Q6UN15
MIM 607686
Ensembl ENSG00000145216
HGNC 19124
HPRD 09646

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information


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