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Sequence in raw or FASTA format:

Database:

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FIP1L1 factor interacting with PAPOLA and CPSF1 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001134937 Homo sapiens factor interacting with PAPOLA and CPSF1 (FIP1L1), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_001134938 Homo sapiens factor interacting with PAPOLA and CPSF1 (FIP1L1), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_030917 Homo sapiens factor interacting with PAPOLA and CPSF1 (FIP1L1), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_005265768 PREDICTED: Homo sapiens factor interacting with PAPOLA and CPSF1 (FIP1L1), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_005265769 PREDICTED: Homo sapiens factor interacting with PAPOLA and CPSF1 (FIP1L1), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_005265770 PREDICTED: Homo sapiens factor interacting with PAPOLA and CPSF1 (FIP1L1), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_005265771 PREDICTED: Homo sapiens factor interacting with PAPOLA and CPSF1 (FIP1L1), transcript variant X4, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_005265772 PREDICTED: Homo sapiens factor interacting with PAPOLA and CPSF1 (FIP1L1), transcript variant X5, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_005265773 PREDICTED: Homo sapiens factor interacting with PAPOLA and CPSF1 (FIP1L1), transcript variant X6, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_005265774 PREDICTED: Homo sapiens factor interacting with PAPOLA and CPSF1 (FIP1L1), transcript variant X7, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_005265775 PREDICTED: Homo sapiens factor interacting with PAPOLA and CPSF1 (FIP1L1), transcript variant X8, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_005265776 PREDICTED: Homo sapiens factor interacting with PAPOLA and CPSF1 (FIP1L1), transcript variant X9, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_005265777 PREDICTED: Homo sapiens factor interacting with PAPOLA and CPSF1 (FIP1L1), transcript variant X10, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_005265778 PREDICTED: Homo sapiens factor interacting with PAPOLA and CPSF1 (FIP1L1), transcript variant X11, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_005265779 PREDICTED: Homo sapiens factor interacting with PAPOLA and CPSF1 (FIP1L1), transcript variant X12, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_005265780 PREDICTED: Homo sapiens factor interacting with PAPOLA and CPSF1 (FIP1L1), transcript variant X13, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_005265781 PREDICTED: Homo sapiens factor interacting with PAPOLA and CPSF1 (FIP1L1), transcript variant X14, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_005265782 PREDICTED: Homo sapiens factor interacting with PAPOLA and CPSF1 (FIP1L1), transcript variant X15, mRNA. GenEZ ORF Cloning On-demand $699.00 18

*Business Day

Related Services

Gene Symbol FIP1L1
Entrez Gene ID 81608
Full Name factor interacting with PAPOLA and CPSF1
Synonyms FIP1, Rhe, hFip1
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4q12

Summary This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008].
Disorder

MIM: 607686

mRNA Protein Product Sequence Price Select
NM_001134937, 201023338 NP_001128409, 201023339 pre-mRNA 3'-end-processing factor FIP1 isoform 2 ORF Sequence $700.00
NM_001134938, 201023340 NP_001128410, 201023341 pre-mRNA 3'-end-processing factor FIP1 isoform 3 ORF Sequence $550.00
NM_030917, 201023337 NP_112179, 40254978 pre-mRNA 3'-end-processing factor FIP1 isoform 1 ORF Sequence $700.00
XM_005265768, 578808662 XP_005265825, 530376839 pre-mRNA 3'-end-processing factor FIP1 isoform X1 ORF Sequence $700.00
XM_005265769, 578808663 XP_005265826, 530376841 pre-mRNA 3'-end-processing factor FIP1 isoform X2 ORF Sequence $700.00
XM_005265770, 578808664 XP_005265827, 530376843 pre-mRNA 3'-end-processing factor FIP1 isoform X3 ORF Sequence $700.00
XM_005265771, 578808665 XP_005265828, 530376845 pre-mRNA 3'-end-processing factor FIP1 isoform X4 ORF Sequence $700.00
XM_005265772, 578808666 XP_005265829, 530376847 pre-mRNA 3'-end-processing factor FIP1 isoform X5 ORF Sequence $700.00
XM_005265773, 578808667 XP_005265830, 530376849 pre-mRNA 3'-end-processing factor FIP1 isoform X6 ORF Sequence $700.00
XM_005265774, 578808668 XP_005265831, 530376851 pre-mRNA 3'-end-processing factor FIP1 isoform X7 ORF Sequence $700.00
XM_005265775, 578808669 XP_005265832, 530376853 pre-mRNA 3'-end-processing factor FIP1 isoform X8 ORF Sequence $700.00
XM_005265776, 578808670 XP_005265833, 530376855 pre-mRNA 3'-end-processing factor FIP1 isoform X9 ORF Sequence $700.00
XM_005265777, 578808671 XP_005265834, 530376857 pre-mRNA 3'-end-processing factor FIP1 isoform X10 ORF Sequence $550.00
XM_005265778, 578808672 XP_005265835, 530376859 pre-mRNA 3'-end-processing factor FIP1 isoform X11 ORF Sequence $550.00
XM_005265779, 578808673 XP_005265836, 530376861 pre-mRNA 3'-end-processing factor FIP1 isoform X12 ORF Sequence $550.00
XM_005265780, 578808674 XP_005265837, 530376863 pre-mRNA 3'-end-processing factor FIP1 isoform X13 ORF Sequence $550.00
XM_005265781, 578808675 XP_005265838, 530376865 pre-mRNA 3'-end-processing factor FIP1 isoform X14 ORF Sequence $550.00
XM_005265782, 578808676 XP_005265839, 530376867 pre-mRNA 3'-end-processing factor FIP1 isoform X15 ORF Sequence $550.00
KEGG
hsa03015mRNA surveillance pathway
Homo sapiens (human)FIP1L1NP_112179.2
Pan troglodytes (chimpanzee)FIP1L1XP_001147149.1
Macaca mulatta (Rhesus monkey)FIP1L1XP_001090808.1
Rattus norvegicus (Norway rat)Fip1l1NP_001008296.1
Xenopus (Silurana) tropicalis (western clawed frog)fip1l1NP_001037890.1
Process
IDNameEvidence
GO:0006397mRNA processingIEA
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005730nucleolusIDA
GO:0005847mRNA cleavage and polyadenylation specificity factor complexIEA
Function
IDNameEvidence
GO:0044822poly(A) RNA bindingIDA
GeneCards FIP1L1
UniProt Q6UN15
Vega OTTHUMG00000128701
MIM 607686
Ensembl ENSG00000145216
HGNC 19124
HPRD 09646

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the FIP1L1 gene?

The FIP1L1 gene provides instructions for making part of a protein complex named cleavage and polyadenylation specificity factor (CPSF). This complex of proteins plays an important role in processing molecules called messenger RNAs (mRNAs), which serve as the genetic blueprints for making proteins. The CPSF protein complex helps add a string of the RNA building block adenine to the mRNA, creating a polyadenine tail or poly(A) tail. The poly(A) tail is important for stability of the mRNA and for protein production from the blueprint.

Interactant

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