Sequence in raw or FASTA format:
FIP1L1 factor interacting with PAPOLA and CPSF1 [Homo sapiens (human)]
|Entrez Gene ID||81608|
|Full Name||factor interacting with PAPOLA and CPSF1|
|Synonyms||FIP1, Rhe, hFip1|
|General protein information|
|Organism||Homo sapiens (human)|
|Summary||This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008].|
|hsa03015||mRNA surveillance pathway|
|Homo sapiens (human)||FIP1L1||NP_112179.2|
|Pan troglodytes (chimpanzee)||FIP1L1||XP_001147149.1|
|Macaca mulatta (Rhesus monkey)||FIP1L1||XP_001090808.1|
|Rattus norvegicus (Norway rat)||Fip1l1||NP_001008296.1|
|Xenopus (Silurana) tropicalis (western clawed frog)||fip1l1||NP_001037890.1|
|GO:0005847||mRNA cleavage and polyadenylation specificity factor complex||IEA|
|GO:0044822||poly(A) RNA binding||IDA|
What is the normal function of the FIP1L1 gene?
The FIP1L1 gene provides instructions for making part of a protein complex named cleavage and polyadenylation specificity factor (CPSF). This complex of proteins plays an important role in processing molecules called messenger RNAs (mRNAs), which serve as the genetic blueprints for making proteins. The CPSF protein complex helps add a string of the RNA building block adenine to the mRNA, creating a polyadenine tail or poly(A) tail. The poly(A) tail is important for stability of the mRNA and for protein production from the blueprint.
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