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Sequence in raw or FASTA format:

Database:

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DOCK8 dedicator of cytokinesis 8 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu17463 NM_001190458 Homo sapiens dedicator of cytokinesis 8 (DOCK8), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 30 $2699.00
OHu17616 NM_001193536 Homo sapiens dedicator of cytokinesis 8 (DOCK8), transcript variant 3, mRNA. pcDNA3.1+-DYK On-demand 35 $3749.00
OHu17906 NM_203447 Homo sapiens dedicator of cytokinesis 8 (DOCK8), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 35 $3749.00
OHu17463C NM_001190458 Homo sapiens dedicator of cytokinesis 8 (DOCK8), transcript variant 2, mRNA. Customized vector On-demand 30 $2699.00
OHu17616C NM_001193536 Homo sapiens dedicator of cytokinesis 8 (DOCK8), transcript variant 3, mRNA. Customized vector On-demand 35 $3749.00
OHu17906C NM_203447 Homo sapiens dedicator of cytokinesis 8 (DOCK8), transcript variant 1, mRNA. Customized vector On-demand 35 $3749.00

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Gene Symbol DOCK8
Entrez Gene ID 81704
Full Name dedicator of cytokinesis 8
Synonyms HEL-205, MRD2, ZIR8
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

9

9p24.3

Summary This gene encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with Rho GTPases and are components of intracellular signaling networks. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Jun 2010].
Disorder

MIM: 611432

Mental retardation, autosomal dominant 2 (3); Hyper-IgE recurrent

mRNA Protein Product Sequence Price Select
NM_001190458, 299473743 NP_001177387, 299473744 dedicator of cytokinesis protein 8 isoform 2 ORF Sequence $2500.00
NM_001193536, 302129690 NP_001180465, 302129691 dedicator of cytokinesis protein 8 isoform 3 ORF Sequence $3500.00
NM_203447, 254750683 NP_982272, 238231392 dedicator of cytokinesis protein 8 isoform 1 ORF Sequence $3500.00
Reactome
REACT_604Hemostasis
REACT_24970Factors involved in megakaryocyte development and platelet production
Homo sapiens (human)DOCK8NP_982272.2
Pan troglodytes (chimpanzee)DOCK8XP_003312029.1
Macaca mulatta (Rhesus monkey)LOC698081XP_002808151.1
Canis lupus familiaris (dog)DOCK8XP_005615946.1
Bos taurus (cattle)DOCK8NP_001178461.1
Mus musculus (house mouse)Dock8NP_083061.2
Rattus norvegicus (Norway rat)Dock8NP_001032882.2
Gallus gallus (chicken)DOCK8XP_424926.4
Danio rerio (zebrafish)dock8XP_001920107.4
Xenopus (Silurana) tropicalis (western clawed frog)dock8XP_002935647.2
Process
IDNameEvidence
GO:0007264small GTPase mediated signal transductionIEA
GO:0007596blood coagulationTAS
GO:0043547positive regulation of GTPase activityIEA
GO:0061485memory T cell proliferationIMP
Component
IDNameEvidence
GO:0005829cytosolTAS
GO:0016020membraneIDA
Function
IDNameEvidence
GO:0005085guanyl-nucleotide exchange factor activityIEA
GO:0005515protein bindingIPI
GeneCards DOCK8
UniProt E2J6M6, E2J6M5, Q8NF50
Vega OTTHUMG00000078789
MIM 611432
Ensembl ENSG00000107099
HGNC 19191
HPRD 10920

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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