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ARID1A AT rich interactive domain 1A (SWI-like) [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_006015 Homo sapiens AT rich interactive domain 1A (SWI-like) (ARID1A), transcript variant 1, mRNA. ORF Sequence $3086.10
Peptide Services
Antibody Services
Protein Services
NM_139135 Homo sapiens AT rich interactive domain 1A (SWI-like) (ARID1A), transcript variant 2, mRNA. ORF Sequence $2793.15
Peptide Services
Antibody Services
Protein Services


Gene Symbol ARID1A
Entrez Gene ID 8289
Full Name AT rich interactive domain 1A (SWI-like)
Synonyms B120, BAF250, BAF250a, BM029, C1orf4, P270, SMARCF1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1p35.3

Summary This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Disorder

MIM: 603024

mRNA Protein Product Sequence Price Select
NM_006015, 117968607 NP_006006, 21264565 AT-rich interactive domain-containing protein 1A isoform a Full Length $0.00
ORF Sequence $3086.10
NM_139135, 117968462 NP_624361, 21264575 AT-rich interactive domain-containing protein 1A isoform b Full Length $3570.30
ORF Sequence $2793.15
Homo sapiens (human)ARID1ANP_006006.3
Pan troglodytes (chimpanzee)ARID1AXP_513235.4
Macaca mulatta (Rhesus monkey)LOC719949XP_002808326.1
Canis lupus familiaris (dog)ARID1AXP_852546.3
Bos taurus (cattle)ARID1ANP_001192714.1
Mus musculus (house mouse)Arid1aNP_001074288.1
Rattus norvegicus (Norway rat)Arid1aNP_001100105.1
Gallus gallus (chicken)ARID1AXP_417693.3
Danio rerio (zebrafish)arid1abXP_696565.5
Drosophila melanogaster (fruit fly)osaNP_996228.1
GeneCards ARID1A
PDB 1RYU
UniProt O14497
MIM 603024
Ensembl ENSG00000117713
HGNC 11110
HPRD 04319

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
AT-rich interactive domain-containing protein 1A
Names
AT-rich interactive domain-containing protein 1A
osa homolog 1
SWI-like protein
brain protein 120
OSA1 nuclear protein
BRG1-associated factor 250a
SWI/SNF complex protein p270
chromatin remodeling factor p250
ARID domain-containing protein 1A
SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1

Interactant

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