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ARID1A AT rich interactive domain 1A (SWI-like) [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_006015 Homo sapiens AT rich interactive domain 1A (SWI-like) (ARID1A), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand TBD TBD
NM_139135 Homo sapiens AT rich interactive domain 1A (SWI-like) (ARID1A), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand TBD TBD

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Gene Symbol ARID1A
Entrez Gene ID 8289
Full Name AT rich interactive domain 1A (SWI-like)
Synonyms B120, BAF250, BAF250a, BM029, C1orf4, ELD, MRD14, OSA1, P270, SMARCF1, hELD, hOSA1
General protein information
Preferred Names
AT-rich interactive domain-containing protein 1A
AT-rich interactive domain-containing protein 1A
osa homolog 1
SWI-like protein
brain protein 120
OSA1 nuclear protein
BRG1-associated factor 250a
SWI/SNF complex protein p270
chromatin remodeling factor p250
ARID domain-containing protein 1A
SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

MIM: 603024

mRNA Protein Product Sequence Price Select
NM_006015, 117968607 NP_006006, 21264565 AT-rich interactive domain-containing protein 1A isoform a ORF Sequence $3500.00
NM_139135, 117968462 NP_624361, 21264575 AT-rich interactive domain-containing protein 1A isoform b ORF Sequence $3500.00
WP2263Prostate Cancer
Homo sapiens (human)ARID1ANP_006006.3
Pan troglodytes (chimpanzee)ARID1AXP_513235.4
Macaca mulatta (Rhesus monkey)LOC719949XP_002808326.1
Canis lupus familiaris (dog)ARID1AXP_005617799.1
Bos taurus (cattle)ARID1ANP_001192714.1
Mus musculus (house mouse)Arid1aNP_001074288.1
Rattus norvegicus (Norway rat)Arid1aNP_001100105.1
Gallus gallus (chicken)ARID1AXP_417693.4
Danio rerio (zebrafish)arid1abXP_696565.6
Xenopus (Silurana) tropicalis (western clawed frog)arid1aXP_002934685.2
GO:0000122negative regulation of transcription from RNA polymerase II promoterIEA
GO:0001843neural tube closureIEA
GO:0003205cardiac chamber developmentIEA
GO:0003408optic cup formation involved in camera-type eye developmentIEA
GO:0006337nucleosome disassemblyIDA
GO:0006338chromatin remodelingIDA
GO:0006351transcription, DNA-templatedIEA
GO:0006357regulation of transcription from RNA polymerase II promoterNAS
GO:0030520intracellular estrogen receptor signaling pathwayIDA
GO:0030521androgen receptor signaling pathwayIDA
GO:0030900forebrain developmentIEA
GO:0042766nucleosome mobilizationTAS
GO:0042921glucocorticoid receptor signaling pathwayIDA
GO:0043044ATP-dependent chromatin remodelingIEA
GO:0045893positive regulation of transcription, DNA-templatedIDA
GO:0048096chromatin-mediated maintenance of transcriptionTAS
GO:0060674placenta blood vessel developmentIEA
GO:0000790nuclear chromatinIDA
GO:0016514SWI/SNF complexIDA
GO:0071564npBAF complexISS
GO:0071565nBAF complexISS
GO:0003677DNA bindingIDA
GO:0003677DNA bindingNAS
GO:0003713transcription coactivator activityNAS
GO:0005515protein bindingIPI
GO:0016922ligand-dependent nuclear receptor bindingIPI
GO:0031491nucleosome bindingIEA
GeneCards ARID1A
UniProt O14497
Vega OTTHUMG00000004004
MIM 603024
Ensembl ENSG00000117713
HGNC 11110
HPRD 04319

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the ARID1A gene?

The ARID1A gene provides instructions for making a protein that forms one piece (subunit) of several different SWI/SNF protein complexes. SWI/SNF complexes regulate gene activity (expression) by a process known as chromatin remodeling. Chromatin is the network of DNA and protein that packages DNA into chromosomes. The structure of chromatin can be changed (remodeled) to alter how tightly DNA is packaged. Chromatin remodeling is one way gene expression is regulated during development; when DNA is tightly packed, gene expression is lower than when DNA is loosely packed.

Through their ability to regulate gene activity, SWI/SNF complexes are involved in many processes, including repairing damaged DNA; copying (replicating) DNA; and controlling the growth, division, and maturation (differentiation) of cells. The ARID1A protein and other SWI/SNF subunits are thought to act as tumor suppressors, which keep cells from growing and dividing too rapidly or in an uncontrolled way.

The ARID1A subunit is able to attach (bind) to DNA and is thought to help target SWI/SNF complexes to the chromatin location that needs to be remodeled.


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