SLX4 SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) [Homo sapiens (human)]
| Gene Symbol | SLX4 |
| Entrez Gene ID | 84464 |
| Full Name | SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) |
| Synonyms | BTBD12, FANCP, KIAA1784, KIAA1987, MUS312 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
16 16p13.3 |
| Summary | This gene encodes a structure-specific endonuclease subunit. The encoded protein contains a central BTB domain and it forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases, and also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), the protein kinase PLK1 and the uncharacterized protein C20orf94. The multiprotein complex is required for repair of specific types of DNA lesions and is critical for cellular responses to replication fork failure. The encoded protein acts as a docking platform for the assembly of multiple structure-specific endonucleases. COMPLETENESS: complete on the 3' end. |
| Disorder | MIM: 613278 |
| mRNA | NM_032444, 63252862 |
| Protein | NP_115820, 63252863 |
| Product | structure-specific endonuclease subunit SLX4 |
| RefSeq Status | REVIEWED |
| Homo sapiens (human) | SLX4 | NP_115820.2 |
| Pan troglodytes (chimpanzee) | SLX4 | XP_510772.2 |
| Canis lupus familiaris (dog) | SLX4 | XP_536992.2 |
| Bos taurus (cattle) | SLX4 | XP_589654.2 |
| Mus musculus (house mouse) | Btbd12 | NP_803423.2 |
| Rattus norvegicus (Norway rat) | Btbd12 | XP_220211.4 |
| Gallus gallus (chicken) | BTBD12 | XP_414962.2 |
| Danio rerio (zebrafish) | slx4 | XP_001341238.1 |
| ID | Name | Evidence |
| GO:0000724 | double-strand break repair via homologous recombination | IMP |
| GO:0006281 | DNA repair | IMP |
| GO:0006289 | nucleotide-excision repair | IMP |
| GO:0006310 | DNA recombination | IEA |
| GO:0010792 | DNA double-strand break processing involved in repair via single-strand annealing | IMP |
| GO:0043085 | positive regulation of catalytic activity | IDA |
Component
| ID | Name | Evidence |
| GO:0000784 | nuclear chromosome, telomeric region | IDA |
| GO:0000790 | nuclear chromatin | IDA |
| GO:0005634 | nucleus | IEA |
| GO:0033557 | Slx1-Slx4 complex | IDA |
| GO:0048476 | Holliday junction resolvase complex | IDA |
| GO:0070522 | ERCC4-ERCC1 complex | IDA |
Function
| ID | Name | Evidence |
| GO:0005515 | protein binding | IPI |
| GO:0008047 | enzyme activator activity | IDA |
| GO:0008821 | crossover junction endodeoxyribonuclease activity | IDA |
| GO:0017108 | 5'-flap endonuclease activity | IDA |
| GO:0048257 | 3'-flap endonuclease activity | IDA |
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