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CASR calcium-sensing receptor [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000388 Homo sapiens calcium-sensing receptor (CASR), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
NM_001178065 Homo sapiens calcium-sensing receptor (CASR), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_005247836 PREDICTED: Homo sapiens calcium-sensing receptor (CASR), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_005247837 PREDICTED: Homo sapiens calcium-sensing receptor (CASR), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_006713789 PREDICTED: Homo sapiens calcium-sensing receptor (CASR), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_006713790 PREDICTED: Homo sapiens calcium-sensing receptor (CASR), transcript variant X4, mRNA. GenEZ ORF Cloning On-demand $1699.00 25

*Business Day

Related Services

Gene Symbol CASR
Entrez Gene ID 846
Full Name calcium-sensing receptor
General protein information
Preferred Names
extracellular calcium-sensing receptor
extracellular calcium-sensing receptor
parathyroid Ca(2+)-sensing receptor 1
parathyroid cell calcium-sensing receptor
Gene Type protein-coding
Organism Homo sapiens (human)



Summary The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism. [provided by RefSeq, Jul 2008].

MIM: 601199

Hypocalciuric hypercalcemia, type I, 145980 (3); Hyperparathyroidism,

mRNA Protein Product Sequence Price Select
NM_000388, 189409146 NP_000379, 37577159 extracellular calcium-sensing receptor isoform 2 precursor ORF Sequence $1500.00
NM_001178065, 296010810 NP_001171536, 296010811 extracellular calcium-sensing receptor isoform 1 precursor ORF Sequence $1500.00
XM_005247836, 530375404 XP_005247893, 530375405 extracellular calcium-sensing receptor isoform X1 ORF Sequence $1500.00
XM_005247837, 530375406 XP_005247894, 530375407 extracellular calcium-sensing receptor isoform X2 ORF Sequence $750.00
XM_006713789, 578807817 XP_006713852, 578807818 extracellular calcium-sensing receptor isoform X3 ORF Sequence $1500.00
XM_006713790, 578807819 XP_006713853, 578807820 extracellular calcium-sensing receptor isoform X4 ORF Sequence $1500.00
WP501GPCRs, Class C Metabotropic glutamate, pheromone
Pathway Interaction Database
ecadherin_keratinocyte_pathwayE-cadherin signaling in keratinocytes
REACT_19184GPCR downstream signaling
REACT_19231G alpha (i) signalling events
REACT_18283G alpha (q) signalling events
REACT_14797Signaling by GPCR
REACT_18319Class C/3 (Metabotropic glutamate/pheromone receptors)
REACT_21340GPCR ligand binding
REACT_111102Signal Transduction
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
Homo sapiens (human)CASRNP_001171536.1
Pan troglodytes (chimpanzee)CASRXP_516689.2
Macaca mulatta (Rhesus monkey)CASRXP_001112009.2
Canis lupus familiaris (dog)CASRNP_001074978.1
Bos taurus (cattle)CASRNP_776427.1
Mus musculus (house mouse)CasrNP_038831.2
Rattus norvegicus (Norway rat)CasrNP_058692.1
Gallus gallus (chicken)CASRXP_416491.3
Danio rerio (zebrafish)LOC560607XP_689097.1
Xenopus (Silurana) tropicalis (western clawed frog)LOC100496505XP_004919842.1
GO:0005513detection of calcium ionTAS
GO:0006874cellular calcium ion homeostasisTAS
GO:0007186G-protein coupled receptor signaling pathwayIEA
GO:0007635chemosensory behaviorTAS
GO:0008152metabolic processTAS
GO:0009653anatomical structure morphogenesisTAS
GO:0070509calcium ion importIDA
GO:0005886plasma membraneTAS
GO:0005887integral component of plasma membraneTAS
GO:0004435phosphatidylinositol phospholipase C activityTAS
GO:0004930G-protein coupled receptor activityIEA
GO:0005515protein bindingIPI
GeneCards CASR
UniProt P41180
Vega OTTHUMG00000159491
MIM 601199
Ensembl ENSG00000036828
HGNC 1514
HPRD 03122

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the CASR gene?

The CASR gene provides instructions for making a protein called the calcium-sensing receptor (CaSR). Calcium molecules attach (bind) to the CaSR, which allows this protein to monitor and regulate the amount of calcium in the blood. The receptor is turned on (activated) when a certain concentration of calcium is reached, and the activated receptor sends signals to block processes that increase the amount of calcium in the blood.

The CaSR is found in abundance in cells of the parathyroid glands. The parathyroid glands produce and release a hormone called parathyroid hormone that works to increase the levels of calcium in the blood. When calcium binds to the CaSR in the parathyroid glands, the production of parathyroid hormone is blocked, which prevents the release of more calcium into the blood. CaSR signaling also blocks the growth and division (proliferation) of cells that make up the parathyroid glands.

The CaSR is also found in kidney cells. Kidneys filter fluid and waste products in the body and can reabsorb needed nutrients and release them back into the blood. Calcium binding to the CaSR in kidney cells blocks the reabsorption of calcium from the filtered fluids.


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