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CAT catalase [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001752 Homo sapiens catalase (CAT), mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12

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Related Services

Gene Symbol CAT
Entrez Gene ID 847
Full Name catalase
Synonyms
General protein information
Preferred Names
catalase
Names
catalase
NP_001743.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11p13

Summary This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009].
Disorder

MIM: 115500

Acatalasemia (3)

mRNA Protein Product Sequence Price Select
NM_001752, 260436906 NP_001743, 4557014 catalase ORF Sequence $360.00
KEGG
hsa00380Tryptophan metabolism
hsa00630Glyoxylate and dicarboxylate metabolism
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa04146Peroxisome
hsa04068FoxO signaling pathway
WikiPathways
WP15Selenium Pathway
WP710DNA damage response (only ATM dependent)
WP465Tryptophan metabolism
WP176Folate Metabolism
WP408Oxidative Stress
WP2447Amyotrophic lateral sclerosis (ALS)
Pathway Interaction Database
foxopathwayFoxO family signaling
BIOCYC
META_PWY66-162ethanol degradation IV
HUMAN_PWY66-162ethanol degradation IV
HUMAN_DETOX1-PWYsuperoxide radicals degradation
Reactome
REACT_2086Purine catabolism
REACT_522Purine metabolism
REACT_1698Metabolism of nucleotides
REACT_111217Metabolism
REACT_120956Cellular responses to stress
REACT_172715Detoxification of Reactive Oxygen Species
Homo sapiens (human)CATNP_001743.1
Pan troglodytes (chimpanzee)CATXP_001147928.1
Macaca mulatta (Rhesus monkey)CATXP_001115625.1
Canis lupus familiaris (dog)CATNP_001002984.1
Bos taurus (cattle)CATNP_001030463.1
Mus musculus (house mouse)CatNP_033934.2
Rattus norvegicus (Norway rat)CatNP_036652.1
Gallus gallus (chicken)CATNP_001026386.1
Danio rerio (zebrafish)catNP_570987.1
Drosophila melanogaster (fruit fly)CatNP_536731.1
Drosophila melanogaster (fruit fly)CG9314NP_001260268.1
Caenorhabditis elegansctl-3NP_741058.1
Caenorhabditis elegansctl-2NP_001022473.1
Caenorhabditis elegansctl-1NP_496979.2
Arabidopsis thaliana (thale cress)CAT2NP_195235.1
Arabidopsis thaliana (thale cress)CAT1NP_564121.1
Xenopus (Silurana) tropicalis (western clawed frog)cat.1NP_001016716.1
Xenopus (Silurana) tropicalis (western clawed frog)cat.2NP_001072167.1
Process
IDNameEvidence
GO:0000302response to reactive oxygen speciesIMP
GO:0001649osteoblast differentiationIDA
GO:0001657ureteric bud developmentIEA
GO:0001666response to hypoxiaIEA
GO:0001822kidney developmentIEA
GO:0006144purine nucleobase metabolic processTAS
GO:0006195purine nucleotide catabolic processTAS
GO:0006641triglyceride metabolic processIEA
GO:0008203cholesterol metabolic processIEA
GO:0009060aerobic respirationIEA
GO:0009650UV protectionIMP
GO:0014068positive regulation of phosphatidylinositol 3-kinase signalingIEA
GO:0020027hemoglobin metabolic processIEA
GO:0032088negative regulation of NF-kappaB transcription factor activityIEA
GO:0033197response to vitamin EIEA
GO:0042697menopauseIEA
GO:0042744hydrogen peroxide catabolic processIDA
GO:0043066negative regulation of apoptotic processIMP
GO:0044281small molecule metabolic processTAS
GO:0051092positive regulation of NF-kappaB transcription factor activityIEA
GO:0051262protein tetramerizationIDA
GO:0051289protein homotetramerizationIDA
GO:0051781positive regulation of cell divisionIEA
GO:0055086nucleobase-containing small molecule metabolic processTAS
GO:0055093response to hyperoxiaIEA
GO:0071363cellular response to growth factor stimulusIEA
Component
IDNameEvidence
GO:0005758mitochondrial intermembrane spaceIEA
GO:0005764lysosomeIEA
GO:0005777peroxisomeIDA
GO:0005778peroxisomal membraneISS
GO:0005782peroxisomal matrixTAS
GO:0005783endoplasmic reticulumIEA
GO:0005794Golgi apparatusIEA
GO:0005829cytosolIEA
GO:0005886plasma membraneIEA
GO:0016020membraneIDA
GO:0043231intracellular membrane-bounded organelleIDA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0004046aminoacylase activityIEA
GO:0004096catalase activityIDA
GO:0004096catalase activityTAS
GO:0005102receptor bindingIPI
GO:0016209antioxidant activityIDA
GO:0016684oxidoreductase activity, acting on peroxide as acceptorISS
GO:0019899enzyme bindingIPI
GO:0020037heme bindingIDA
GO:0042803protein homodimerization activityIDA
GO:0046872metal ion bindingIEA
GO:0050661NADP bindingIDA
GeneCards CAT
PDB 1DGG, 1F4J, 1DGF, 1QQW, 1DGB, 1DGH
UniProt P04040
Vega OTTHUMG00000044353
MIM 115500
Ensembl ENSG00000121691
HGNC 1516
HPRD 00282

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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