CAT catalase [Homo sapiens (human)]
| Gene Symbol | CAT |
| Entrez Gene ID | 847 |
| Full Name | catalase |
| Synonyms | MGC138422, MGC138424 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
11 11p13 |
| Summary | This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq]. |
| Disorder | MIM: 115500 Acatalasemia (3) |
| hsa01100 | Metabolic pathways |
| hsa05014 | Amyotrophic lateral sclerosis (ALS) |
| hsa00380 | Tryptophan metabolism |
| hsa04146 | Peroxisome |
Pathway Interaction Database
| foxopathway | FoxO family signaling |
WikiPathways
| WP465 | Tryptophan metabolism |
| WP408 | Oxidative Stress |
| WP176 | Folate Metabolism |
| WP15 | Selenium Pathway |
BIOCYC
| META_PWY66-162 | oxidative ethanol degradation III |
| META_PWY-5147 | oleate biosynthesis I (plants) |
Reactome
| REACT_2086 | Purine catabolism |
| REACT_1698 | Metabolism of nucleotides |
| REACT_522 | Purine metabolism |
| Homo sapiens (human) | CAT | NP_001743.1 |
| Pan troglodytes (chimpanzee) | CAT | XP_001147928.1 |
| Canis lupus familiaris (dog) | CAT | NP_001002984.1 |
| Bos taurus (cattle) | CAT | NP_001030463.1 |
| Mus musculus (house mouse) | Cat | NP_033934.1 |
| Rattus norvegicus (Norway rat) | Cat | NP_036652.1 |
| Gallus gallus (chicken) | CAT | XP_001233111.1 |
| Danio rerio (zebrafish) | cat | NP_570987.1 |
| Drosophila melanogaster (fruit fly) | Cat | NP_536731.1 |
| Drosophila melanogaster (fruit fly) | CG9314 | NP_609248.1 |
| Caenorhabditis elegans | ctl-1 | NP_496979.2 |
| Caenorhabditis elegans | ctl-2 | NP_001022473.1 |
| Caenorhabditis elegans | ctl-3 | NP_741058.1 |
| Arabidopsis thaliana (thale cress) | CAT2 | NP_195235.1 |
| Arabidopsis thaliana (thale cress) | CAT1 | NP_564121.1 |
| ID | Name | Evidence |
| GO:0000302 | response to reactive oxygen species | IMP |
| GO:0006144 | purine base metabolic process | TAS |
| GO:0006195 | purine nucleotide catabolic process | TAS |
| GO:0009650 | UV protection | IMP |
| GO:0042744 | hydrogen peroxide catabolic process | IDA |
| GO:0043066 | negative regulation of apoptosis | IMP |
| GO:0051262 | protein tetramerization | IDA |
| GO:0051781 | positive regulation of cell division | IEA |
| GO:0055086 | nucleobase, nucleoside and nucleotide metabolic process | TAS |
Component
| ID | Name | Evidence |
| GO:0005758 | mitochondrial intermembrane space | IEA |
| GO:0005764 | lysosome | IEA |
| GO:0005777 | peroxisome | IDA |
| GO:0005778 | peroxisomal membrane | ISS |
| GO:0005782 | peroxisomal matrix | TAS |
| GO:0005783 | endoplasmic reticulum | IEA |
| GO:0005794 | Golgi apparatus | IEA |
| GO:0005829 | cytosol | IEA |
| GO:0005886 | plasma membrane | IEA |
Function
| ID | Name | Evidence |
| GO:0004096 | catalase activity | IDA |
| GO:0004096 | catalase activity | TAS |
| GO:0005515 | protein binding | IPI |
| GO:0016684 | oxidoreductase activity, acting on peroxide as acceptor | ISS |
| GO:0020037 | heme binding | IDA |
| GO:0042803 | protein homodimerization activity | IDA |
| GO:0046872 | metal ion binding | IEA |
| GO:0050661 | NADP binding | IDA |
Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.
 |
Secured Online Quotation |
 |
Email: gene@genscript.com |
 |
Phone: 1-877-436-7274 (Toll-Free) 1-732-885-9188 |
 |
Fax: 1-732-210-0262 1-732-885-5878 |