PIGO phosphatidylinositol glycan anchor biosynthesis, class O [Homo sapiens (human)]
| Gene Symbol | PIGO |
| Entrez Gene ID | 84720 |
| Full Name | phosphatidylinositol glycan anchor biosynthesis, class O |
| Synonyms | DKFZp434M222, FLJ00135, MGC20536, MGC3079, RP11-182N22.4 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
9 9p13.3 |
| Summary | This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. This protein is involved in the transfer of ethanolaminephosphate (EtNP) to the third mannose in GPI. At least three alternatively spliced transcripts encoding two distinct isoforms have been found for this gene. [provided by RefSeq]. |
| Disorder | MIM: |
| mRNA | NM_152850, 319918880 |
| Protein | NP_690577, 38045917 |
| Product | GPI ethanolamine phosphate transferase 3 isoform 2 |
| RefSeq Status | REVIEWED |
| mRNA | NM_001201484, 319918881 |
| Protein | NP_001188413, 319918882 |
| Product | GPI ethanolamine phosphate transferase 3 isoform 2 |
| RefSeq Status | REVIEWED |
| mRNA | NM_032634, 319918879 |
| Protein | NP_116023, 23397648 |
| Product | GPI ethanolamine phosphate transferase 3 isoform 1 |
| RefSeq Status | REVIEWED |
| hsa01100 | Metabolic pathways |
| hsa00563 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis |
Reactome
| REACT_1853 | Post-translational modification: synthesis of GPI-anchored proteins |
| REACT_952 | Synthesis of glycosylphosphatidylinositol (GPI) |
| REACT_17015 | Metabolism of proteins |
| REACT_22161 | Post-translational protein modification |
| Homo sapiens (human) | PIGO | NP_116023.2 |
| Pan troglodytes (chimpanzee) | PIGO | XP_520552.2 |
| Canis lupus familiaris (dog) | PIGO | XP_531985.2 |
| Bos taurus (cattle) | PIGO | XP_001251646.1 |
| Mus musculus (house mouse) | Pigo | NP_064419.1 |
| Rattus norvegicus (Norway rat) | Pigo | XP_233141.4 |
| Gallus gallus (chicken) | PIGO | XP_001232870.1 |
| Danio rerio (zebrafish) | LOC563993 | XP_692445.3 |
| Drosophila melanogaster (fruit fly) | CG12263 | NP_611332.1 |
| Caenorhabditis elegans | C27A12.9 | NP_491750.3 |
| Arabidopsis thaliana (thale cress) | AT5G17250 | NP_197227.4 |
| ID | Name | Evidence |
| GO:0006501 | C-terminal protein lipidation | TAS |
| GO:0006506 | GPI anchor biosynthetic process | ISS |
| GO:0016254 | preassembly of GPI anchor in ER membrane | EXP |
| GO:0043687 | post-translational protein modification | TAS |
| GO:0044267 | cellular protein metabolic process | TAS |
Component
| ID | Name | Evidence |
| GO:0005783 | endoplasmic reticulum | IEA |
| GO:0005789 | endoplasmic reticulum membrane | ISS |
| GO:0016020 | membrane | IEA |
| GO:0016021 | integral to membrane | IEA |
Function
| ID | Name | Evidence |
| GO:0003674 | molecular_function | ND |
| GO:0016740 | transferase activity | IEA |
| GeneCards | PIGO |
| UniProt | Q8TEQ8 |
| Ensembl | ENSG00000165282 |
| HGNC | 23215 |
| HPRD | 15134 |
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