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LMNB2 lamin B2 [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_032737 Homo sapiens lamin B2 (LMNB2), mRNA. ORF Sequence $540.27
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Gene Symbol LMNB2
Entrez Gene ID 84823
Full Name lamin B2
Synonyms LAMB2, LMN2, MGC2721
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

19

19p13.3

Summary This gene encodes a B type nuclear lamin. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Mutations in this gene are associated with acquired partial lipodystrophy. [provided by RefSeq, May 2012].
Disorder

MIM: 150341

Lipodystrophy, partial, acquired, 608709 (3)

mRNA Protein Product Sequence Price Select
NM_032737, 388240800 NP_116126, 388240801 lamin-B2 Full Length $1625.40
ORF Sequence $540.27
Pathway Interaction Database
caspase_pathwayCaspase cascade in apoptosis
WikiPathways
WP314FAS pathway and Stress induction of HSP regulation
Homo sapiens (human)LMNB2NP_116126.3
Pan troglodytes (chimpanzee)LMNB2XP_524044.4
Macaca mulatta (Rhesus monkey)LMNB2XP_002801064.1
Canis lupus familiaris (dog)LMNB2XP_542188.3
Bos taurus (cattle)LMNB2XP_002688997.1
Mus musculus (house mouse)Lmnb2NP_034852.2
Rattus norvegicus (Norway rat)Lmnb2XP_216850.5
Gallus gallus (chicken)LMNB2NP_990616.1
Danio rerio (zebrafish)lmnb2NP_571077.1
Drosophila melanogaster (fruit fly)LamCNP_523742.2
GeneCards LMNB2
PDB 2LLL
UniProt Q03252, J9JID7
MIM 150341
Ensembl ENSG00000176619
HGNC 6638
HPRD 01037

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Interactant

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