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IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu16932 NM_001099856 Homo sapiens inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (IKBKG), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu27490 NM_001145255 Homo sapiens inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (IKBKG), transcript variant 4, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu27518 NM_003639 Homo sapiens inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (IKBKG), transcript variant 3, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu27518 NM_001099857 Homo sapiens inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (IKBKG), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu54455 XM_005274760 PREDICTED: Homo sapiens inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (IKBKG), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu54456 XM_006724853 PREDICTED: Homo sapiens inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (IKBKG), transcript variant X6, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu54457 XM_005274761 PREDICTED: Homo sapiens inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (IKBKG), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu27518 XM_005274763 PREDICTED: Homo sapiens inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (IKBKG), transcript variant X4, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu54458 XM_005274764 PREDICTED: Homo sapiens inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (IKBKG), transcript variant X5, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu16932C NM_001099856 Homo sapiens inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (IKBKG), transcript variant 2, mRNA. Customized vector On-demand 7-9 $269.00
OHu27490C NM_001145255 Homo sapiens inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (IKBKG), transcript variant 4, mRNA. Customized vector On-demand 7-9 $209.00
OHu27518C NM_003639 Homo sapiens inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (IKBKG), transcript variant 3, mRNA. Customized vector On-demand 7-9 $269.00
OHu27518C NM_001099857 Homo sapiens inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (IKBKG), transcript variant 1, mRNA. Customized vector On-demand 7-9 $269.00
OHu54455C XM_005274760 PREDICTED: Homo sapiens inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (IKBKG), transcript variant X1, mRNA. Customized vector On-demand 7-9 $269.00
OHu54456C XM_006724853 PREDICTED: Homo sapiens inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (IKBKG), transcript variant X6, mRNA. Customized vector On-demand 7-9 $269.00
OHu54457C XM_005274761 PREDICTED: Homo sapiens inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (IKBKG), transcript variant X2, mRNA. Customized vector On-demand 7-9 $269.00
OHu27518C XM_005274763 PREDICTED: Homo sapiens inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (IKBKG), transcript variant X4, mRNA. Customized vector On-demand 7-9 $269.00
OHu54458C XM_005274764 PREDICTED: Homo sapiens inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (IKBKG), transcript variant X5, mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol IKBKG
Entrez Gene ID 8517
Full Name inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
Synonyms AMCBX1, FIP-3, FIP3, Fip3p, IKK-gamma, IP, IP1, IP2, IPD2, NEMO, ZC2HC9
General protein information
Preferred Names
NF-kappa-B essential modulator
Names
NF-kappa-B essential modulator
IKKG
IKKAP1
incontinentia pigmenti
IkB kinase gamma subunit
ikB kinase subunit gamma
NFkappaB essential modulator
NF-kappa-B essential modifier
I-kappa-B kinase subunit gamma
ikB kinase-associated protein 1
inhibitor of nuclear factor kappa-B kinase subunit gamma
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

X

Xq28

Summary This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [provided by RefSeq, Aug 2011].
Disorder

MIM: 300248

Incontinentia pigmenti, type II, 308300 (3); Ectodermal dysplasia,

mRNA Protein Product Sequence Price Select
NM_001099856, 544063456 NP_001093326, 223671870 NF-kappa-B essential modulator isoform b ORF Sequence $550.00
NM_001099857, 544063455 NP_001093327, 153792133 NF-kappa-B essential modulator isoform a ORF Sequence $550.00
NM_001145255, 544063458 NP_001138727, 223671872 NF-kappa-B essential modulator isoform c ORF Sequence $400.00
NM_003639, 544063457 NP_003630, 4504631 NF-kappa-B essential modulator isoform a ORF Sequence $550.00
XM_005274760, 578838942 XP_005274817, 530422963 NF-kappa-B essential modulator isoform X1 ORF Sequence $550.00
XM_005274761, 578838945 XP_005274818, 530422965 NF-kappa-B essential modulator isoform X2 ORF Sequence $550.00
XM_005274763, 578838946 XP_005274820, 530422969 NF-kappa-B essential modulator isoform X4 ORF Sequence $550.00
XM_005274764, 578838947 XP_005274821, 530422971 NF-kappa-B essential modulator isoform X5 ORF Sequence $550.00
XM_006724853, 578838943 XP_006724916, 578838944 NF-kappa-B essential modulator isoform X6 ORF Sequence $550.00
KEGG
hsa04010MAPK signaling pathway
hsa04210Apoptosis
hsa04662B cell receptor signaling pathway
hsa04660T cell receptor signaling pathway
hsa05215Prostate cancer
hsa04620Toll-like receptor signaling pathway
hsa04920Adipocytokine signaling pathway
hsa05212Pancreatic cancer
hsa05340Primary immunodeficiency
hsa05221Acute myeloid leukemia
hsa05222Small cell lung cancer
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa05200Pathways in cancer
hsa05131Shigellosis
hsa05220Chronic myeloid leukemia
hsa04062Chemokine signaling pathway
hsa04623Cytosolic DNA-sensing pathway
hsa04622RIG-I-like receptor signaling pathway
hsa04621NOD-like receptor signaling pathway
hsa05142Chagas disease (American trypanosomiasis)
hsa05145Toxoplasmosis
hsa05160Hepatitis C
hsa05166HTLV-I infection
hsa04380Osteoclast differentiation
hsa05168Herpes simplex infection
hsa04151PI3K-Akt signaling pathway
hsa05161Hepatitis B
hsa04064NF-kappa B signaling pathway
hsa05169Epstein-Barr virus infection
hsa05203Viral carcinogenesis
hsa04668TNF signaling pathway
hsa04014Ras signaling pathway
WikiPathways
WP382MAPK signaling pathway
WP254Apoptosis
WP1544MicroRNAs in cardiomyocyte hypertrophy
WP288NLR proteins
WP262EBV LMP1 signaling
WP1433NOD pathway
WP75Toll-like receptor signaling pathway
WP69TCR Signaling Pathway
WP23B Cell Receptor Signaling Pathway
WP231TNF-alpha/NF-kB Signaling Pathway
WP2034Leptin signaling pathway
WP2018RANKL/RANK Signaling Pathway
WP1449Regulation of toll-like receptor signaling pathway
WP2112IL17 signaling pathway
Pathway Interaction Database
il1pathwayIL1-mediated signaling events
tcr_pathwayTCR signaling in naive CD4+ T cells
trail_pathwayTRAIL signaling pathway
faspathwayFAS (CD95) signaling pathway
nfkappabcanonicalpathwayCanonical NF-kappaB pathway
cd8tcrpathwayTCR signaling in naive CD8+ T cells
bcr_5pathwayBCR signaling pathway
fcer1pathwayFc-epsilon receptor I signaling in mast cells
tnfpathwayTNF receptor signaling pathway
p75ntrpathwayp75(NTR)-mediated signaling
Reactome
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_6802Innate Immune System
REACT_6900Immune System
REACT_6809MyD88-independent cascade
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_6890Activated TLR4 signalling
REACT_6966Toll-Like Receptors Cascades
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_12555Downstream TCR signaling
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_12526TCR signaling
REACT_21308MAP kinase activation in TLR cascade
REACT_22232Signaling by Interleukins
REACT_21368JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
REACT_22442Interleukin-1 signaling
REACT_21399activated TAK1 mediates p38 MAPK activation
REACT_21281TAK1 activates NFkB by phosphorylation and activation of IKKs complex
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_75774Adaptive Immune System
REACT_75776NOD1/2 Signaling Pathway
REACT_75913Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
REACT_75790Cytokine Signaling in Immune system
REACT_24918IRAK1 recruits IKK complex
REACT_24969TRAF6 mediated NF-kB activation
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_25354IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
REACT_25374IKK complex recruitment mediated by RIP1
REACT_25359RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
REACT_25039NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_25281TRIF-mediated TLR3/TLR4 signaling
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_118656Activation of NF-kappaB in B cells
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_118823Cytosolic sensors of pathogen-associated DNA
REACT_118764ZBP1(DAI) mediated induction of type I IFNs
REACT_118563RIP-mediated NFkB activation via ZBP1
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163994FCERI mediated NF-kB activation
Homo sapiens (human)IKBKGNP_001093326.2
Pan troglodytes (chimpanzee)LOC100610002XP_003317847.1
Macaca mulatta (Rhesus monkey)IKBKGXP_002806492.1
Canis lupus familiaris (dog)IKBKGXP_005642095.1
Bos taurus (cattle)IKBKGXP_005227781.1
Mus musculus (house mouse)IkbkgNP_001154894.1
Rattus norvegicus (Norway rat)IkbkgNP_954534.1
Danio rerio (zebrafish)ikbkgNP_001014366.1
Xenopus (Silurana) tropicalis (western clawed frog)ikbkgNP_001120221.1
Process
IDNameEvidence
GO:0000187activation of MAPK activityTAS
GO:0001782B cell homeostasisIEA
GO:0002224toll-like receptor signaling pathwayTAS
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTAS
GO:0002756MyD88-independent toll-like receptor signaling pathwayTAS
GO:0006351transcription, DNA-templatedIEA
GO:0006915apoptotic processTAS
GO:0006954inflammatory responseTAS
GO:0006955immune responseTAS
GO:0006974cellular response to DNA damage stimulusIDA
GO:0007249I-kappaB kinase/NF-kappaB signalingTAS
GO:0007250activation of NF-kappaB-inducing kinase activityIEA
GO:0007254JNK cascadeTAS
GO:0009615response to virusTAS
GO:0016032viral processIEA
GO:0032481positive regulation of type I interferon productionTAS
GO:0034134toll-like receptor 2 signaling pathwayTAS
GO:0034138toll-like receptor 3 signaling pathwayTAS
GO:0034142toll-like receptor 4 signaling pathwayTAS
GO:0034146toll-like receptor 5 signaling pathwayTAS
GO:0034162toll-like receptor 9 signaling pathwayTAS
GO:0034166toll-like receptor 10 signaling pathwayTAS
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTAS
GO:0035872nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayTAS
GO:0038095Fc-epsilon receptor signaling pathwayTAS
GO:0038123toll-like receptor TLR1:TLR2 signaling pathwayTAS
GO:0038124toll-like receptor TLR6:TLR2 signaling pathwayTAS
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signalingTAS
GO:0045087innate immune responseTAS
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
GO:0050852T cell receptor signaling pathwayNAS
GO:0050852T cell receptor signaling pathwayTAS
GO:0051092positive regulation of NF-kappaB transcription factor activityIDA
GO:0051092positive regulation of NF-kappaB transcription factor activityTAS
GO:0051403stress-activated MAPK cascadeTAS
GO:0070423nucleotide-binding oligomerization domain containing signaling pathwayTAS
Component
IDNameEvidence
GO:0005622intracellularIDA
GO:0005634nucleusIDA
GO:0005737cytoplasmIDA
GO:0005829cytosolTAS
GO:0008385IkappaB kinase complexIDA
GO:0008385IkappaB kinase complexTAS
GO:0008385IkappaB kinase complexTAS
Function
IDNameEvidence
GO:0004871signal transducer activityTAS
GO:0005515protein bindingIPI
GO:0019904protein domain specific bindingIPI
GO:0042803protein homodimerization activityIDA
GO:0046872metal ion bindingIEA
GO:0046982protein heterodimerization activityIDA
GeneCards IKBKG
UniProt C9J1R1, Q9Y6K9
Vega OTTHUMG00000024234
MIM 300248
Ensembl ENSG00000073009
HGNC 5961
HPRD 02217

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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