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IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001099856 Homo sapiens inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (IKBKG), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_001099857 Homo sapiens inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (IKBKG), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_001145255 Homo sapiens inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (IKBKG), transcript variant 4, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_003639 Homo sapiens inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (IKBKG), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $699.00 18

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Gene Symbol IKBKG
Entrez Gene ID 8517
Full Name inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
Synonyms AMCBX1, FIP-3, FIP3, Fip3p, IKK-gamma, IP, IP1, IP2, IPD2, NEMO
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

X

Xq28

Summary This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [provided by RefSeq, Aug 2011].
Disorder

MIM: 300248

Incontinentia pigmenti, type II, 308300 (3); Ectodermal dysplasia,

mRNA Protein Product Sequence Price Select
NM_001099856, 223671869 NP_001093326, 223671870 NF-kappa-B essential modulator isoform b ORF Sequence $550.00
NM_001099857, 153792132 NP_001093327, 153792133 NF-kappa-B essential modulator isoform a ORF Sequence $550.00
NM_001145255, 223671871 NP_001138727, 223671872 NF-kappa-B essential modulator isoform c ORF Sequence $400.00
NM_003639, 142381344 NP_003630, 4504631 NF-kappa-B essential modulator isoform a ORF Sequence $550.00
KEGG
hsa05203Viral carcinogenesis
hsa04210Apoptosis
hsa04062Chemokine signaling pathway
hsa04623Cytosolic DNA-sensing pathway
hsa05161Hepatitis B
hsa05168Herpes simplex infection
hsa04622RIG-I-like receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa05142Chagas disease (American trypanosomiasis)
hsa04064NF-kappa B signaling pathway
hsa05160Hepatitis C
hsa05200Pathways in cancer
hsa04010MAPK signaling pathway
hsa05221Acute myeloid leukemia
hsa04620Toll-like receptor signaling pathway
hsa05212Pancreatic cancer
hsa05220Chronic myeloid leukemia
hsa05166HTLV-I infection
hsa05145Toxoplasmosis
hsa04151PI3K-Akt signaling pathway
hsa05340Primary immunodeficiency
hsa04660T cell receptor signaling pathway
hsa04621NOD-like receptor signaling pathway
hsa05169Epstein-Barr virus infection
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa04920Adipocytokine signaling pathway
hsa05215Prostate cancer
hsa05222Small cell lung cancer
hsa05131Shigellosis
hsa04380Osteoclast differentiation
Pathway Interaction Database
bcr_5pathwayBCR signaling pathway
nfkappabcanonicalpathwayCanonical NF-kappaB pathway
il1pathwayIL1-mediated signaling events
tcr_pathwayTCR signaling in naive CD4+ T cells
fcer1pathwayFc-epsilon receptor I signaling in mast cells
faspathwayFAS (CD95) signaling pathway
tnfpathwayTNF receptor signaling pathway
cd8tcrpathwayTCR signaling in naive CD8+ T cells
p75ntrpathwayp75(NTR)-mediated signaling
trail_pathwayTRAIL signaling pathway
WikiPathways
WP2034Leptin signaling pathway
WP69TCR Signaling Pathway
WP23B Cell Receptor Signaling Pathway
WP262EBV LMP1 signaling
WP1433NOD pathway
WP2018RANKL/RANK Signaling Pathway
WP288NLR proteins
WP75Toll-like receptor signaling pathway
WP254Apoptosis
WP231TNF-alpha/NF-kB Signaling Pathway
WP1544MicroRNAs in cardiomyocyte hypertrophy
WP382MAPK signaling pathway
Reactome
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_25281NFkB and MAP kinases activation mediated by TLR4 signaling repertoire
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_6802Innate Immune System
REACT_22442Interleukin-1 signaling
REACT_21281TAK1 activates NFkB by phosphorylation and activation of IKKs complex
REACT_25039NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_118638Downstream Signaling Events Of B Cell Receptor (BCR)
REACT_21368JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_75913Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
REACT_6966Toll Receptor Cascades
REACT_12526TCR signaling
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_24969TRAF6 mediated NF-kB activation
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_118563RIP-mediated NFkB activation via DAI
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_118656Activation of NF-kappaB in B Cells
REACT_25374IKK complex recruitment mediated by RIP1
REACT_75776NOD1/2 Signaling Pathway
REACT_25354IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
REACT_6900Immune System
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_21308MAP kinase activation in TLR cascade
REACT_24918IRAK1 recruits IKK complex
REACT_118823Cytosolic sensors of pathogen-associated DNA
REACT_6809MyD88-independent cascade
REACT_22232Signaling by Interleukins
REACT_75790Cytokine Signaling in Immune system
REACT_25359RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
REACT_12555Downstream TCR signaling
REACT_118764DAI mediated induction of type I IFNs
REACT_21399activated TAK1 mediates p38 MAPK activation
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_75774Adaptive Immune System
REACT_6890Activated TLR4 signalling
REACT_25222MyD88 dependent cascade initiated on endosome
Homo sapiens (human)IKBKGNP_001093326.2
Macaca mulatta (Rhesus monkey)IKBKGXP_002806492.1
Bos taurus (cattle)IKBKGNP_776779.1
Mus musculus (house mouse)IkbkgNP_001154893.1
Rattus norvegicus (Norway rat)IkbkgNP_954534.1
Danio rerio (zebrafish)ikbkgNP_001014366.1
GeneCards IKBKG
PDB 3FX0, 3BRT, 2JVY, 2JVX, 3CL3, 3BRV
UniProt Q9Y6K9
MIM 300248
Ensembl ENSG00000073009
HGNC 5961
HPRD 02217

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
NF-kappa-B essential modulator
Names
NF-kappa-B essential modulator
IKKG
IKKAP1
incontinentia pigmenti
IkB kinase gamma subunit
ikB kinase subunit gamma
NFkappaB essential modulator
NF-kappa-B essential modifier
I-kappa-B kinase subunit gamma
ikB kinase-associated protein 1
inhibitor of nuclear factor kappa-B kinase subunit gamma

Interactant



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