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CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu26584 NM_001126055 Homo sapiens calcium/calmodulin-dependent serine protein kinase (MAGUK family) (CASK), transcript variant 3, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu27080 NM_001126054 Homo sapiens calcium/calmodulin-dependent serine protein kinase (MAGUK family) (CASK), transcript variant 2, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu27417 NM_003688 Homo sapiens calcium/calmodulin-dependent serine protein kinase (MAGUK family) (CASK), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu54048 XM_005272686 PREDICTED: Homo sapiens calcium/calmodulin-dependent serine protein kinase (MAGUK family) (CASK), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu54049 XM_006724565 PREDICTED: Homo sapiens calcium/calmodulin-dependent serine protein kinase (MAGUK family) (CASK), transcript variant X3, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu54050 XM_006724566 PREDICTED: Homo sapiens calcium/calmodulin-dependent serine protein kinase (MAGUK family) (CASK), transcript variant X4, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu26584C NM_001126055 Homo sapiens calcium/calmodulin-dependent serine protein kinase (MAGUK family) (CASK), transcript variant 3, mRNA. Customized vector On-demand 12-14 $329.00
OHu27080C NM_001126054 Homo sapiens calcium/calmodulin-dependent serine protein kinase (MAGUK family) (CASK), transcript variant 2, mRNA. Customized vector In-stock 5-7 $149.00
OHu27417C NM_003688 Homo sapiens calcium/calmodulin-dependent serine protein kinase (MAGUK family) (CASK), transcript variant 1, mRNA. Customized vector On-demand 12-14 $329.00
OHu54048C XM_005272686 PREDICTED: Homo sapiens calcium/calmodulin-dependent serine protein kinase (MAGUK family) (CASK), transcript variant X2, mRNA. Customized vector On-demand 12-14 $329.00
OHu54049C XM_006724565 PREDICTED: Homo sapiens calcium/calmodulin-dependent serine protein kinase (MAGUK family) (CASK), transcript variant X3, mRNA. Customized vector On-demand 12-14 $329.00
OHu54050C XM_006724566 PREDICTED: Homo sapiens calcium/calmodulin-dependent serine protein kinase (MAGUK family) (CASK), transcript variant X4, mRNA. Customized vector On-demand 12-14 $329.00

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Gene Symbol CASK
Entrez Gene ID 8573
Full Name calcium/calmodulin-dependent serine protein kinase (MAGUK family)
Synonyms CAGH39, CAMGUK, CMG, FGS4, LIN2, MICPCH, MRXSNA, TNRC8
General protein information
Preferred Names
peripheral plasma membrane protein CASK
Names
peripheral plasma membrane protein CASK
hCASK
protein lin-2 homolog
trinucleotide repeat containing 8
calcium/calmodulin-dependent serine protein kinase membrane-associated guanylate kinase
NP_001119526.1
NP_001119527.1
NP_003679.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

X

Xp11.4

Summary This gene encodes a calcium/calmodulin-dependent serine protein kinase. The encoded protein is a MAGUK (membrane-associated guanylate kinase) protein family member. These proteins are scaffold proteins and the encoded protein is located at synapses in the brain. Mutations in this gene are associated with FG syndrome 4, mental retardation and microcephaly with pontine and cerebellar hypoplasia, and a form of X-linked mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010].
Disorder

MIM: 300172

Mental retardation and microcephaly with pontine and cerebellar

mRNA Protein Product Sequence Price Select
NM_001126054, 193788695 NP_001119526, 186700627 peripheral plasma membrane protein CASK isoform 2 ORF Sequence $660.00
NM_001126055, 193794869 NP_001119527, 186700629 peripheral plasma membrane protein CASK isoform 3 ORF Sequence $750.00
NM_003688, 193788694 NP_003679, 186972120 peripheral plasma membrane protein CASK isoform 1 ORF Sequence $750.00
XM_005272686, 578838130 XP_005272743, 530421616 peripheral plasma membrane protein CASK isoform X2 ORF Sequence $750.00
XM_006724565, 578838131 XP_006724628, 578838132 peripheral plasma membrane protein CASK isoform X3 ORF Sequence $750.00
XM_006724566, 578838133 XP_006724629, 578838134 peripheral plasma membrane protein CASK isoform X4 ORF Sequence $750.00
KEGG
hsa04530Tight junction
WikiPathways
WP2359Parkin-Ubiquitin Proteasomal System pathway
Pathway Interaction Database
syndecan_3_pathwaySyndecan-3-mediated signaling events
syndecan_1_pathwaySyndecan-1-mediated signaling events
syndecan_2_pathwaySyndecan-2-mediated signaling events
Reactome
REACT_23832Nephrin interactions
REACT_111155Cell-Cell communication
REACT_118779Extracellular matrix organization
REACT_163942Syndecan interactions
REACT_163874Non-integrin membrane-ECM interactions
Homo sapiens (human)CASKNP_003679.2
Pan troglodytes (chimpanzee)CASKXP_003317477.2
Macaca mulatta (Rhesus monkey)CASKXP_001095837.2
Canis lupus familiaris (dog)CASKXP_005641318.1
Bos taurus (cattle)CASKNP_001095951.1
Mus musculus (house mouse)CaskNP_001271432.1
Rattus norvegicus (Norway rat)CaskNP_071520.1
Gallus gallus (chicken)CASKXP_416769.3
Danio rerio (zebrafish)caskaNP_694420.1
Drosophila melanogaster (fruit fly)CASKNP_001262811.1
Caenorhabditis eleganslin-2NP_001024587.1
Xenopus (Silurana) tropicalis (western clawed frog)caskNP_001016204.1
Process
IDNameEvidence
GO:0001953negative regulation of cell-matrix adhesionIMP
GO:0006468protein phosphorylationIEA
GO:0007155cell adhesionTAS
GO:0010839negative regulation of keratinocyte proliferationIMP
GO:0030198extracellular matrix organizationTAS
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA
GO:0046939nucleotide phosphorylationTAS
GO:0061045negative regulation of wound healingIMP
GO:0070509calcium ion importIEA
GO:0090280positive regulation of calcium ion importIEA
GO:0090288negative regulation of cellular response to growth factor stimulusIMP
Component
IDNameEvidence
GO:0005604basement membraneIDA
GO:0005652nuclear laminaIDA
GO:0005730nucleolusIDA
GO:0005737cytoplasmIDA
GO:0005829cytosolIEA
GO:0005886plasma membraneTAS
GO:0005911cell-cell junctionIDA
GO:0015629actin cytoskeletonTAS
GO:0016323basolateral plasma membraneIEA
GO:0016363nuclear matrixIDA
GO:0042734presynaptic membraneISS
GO:0060170ciliary membraneISS
Function
IDNameEvidence
GO:0004385guanylate kinase activityTAS
GO:0004674protein serine/threonine kinase activityIEA
GO:0005515protein bindingIPI
GO:0005516calmodulin bindingIEA
GO:0005524ATP bindingIEA
GO:0042043neurexin family protein bindingIEA
GeneCards CASK
UniProt O14936
Vega OTTHUMG00000021378
MIM 300172
Ensembl ENSG00000147044
HGNC 1497
HPRD 02164

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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