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RUNX2 runt-related transcription factor 2 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu21119 NM_001278478 Homo sapiens runt-related transcription factor 2 (RUNX2), transcript variant 4, mRNA. pcDNA3.1+-DYK On-demand TBD $219.00
OHu22430 NM_001015051 Homo sapiens runt-related transcription factor 2 (RUNX2), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand TBD $219.00
OHu22872 NM_001024630 Homo sapiens runt-related transcription factor 2 (RUNX2), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand TBD $219.00
OHu40506 XM_006715231 PREDICTED: Homo sapiens runt-related transcription factor 2 (RUNX2), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand TBD $219.00
OHu40507 XM_006715232 PREDICTED: Homo sapiens runt-related transcription factor 2 (RUNX2), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand TBD $219.00
OHu40508 XM_006715233 PREDICTED: Homo sapiens runt-related transcription factor 2 (RUNX2), transcript variant X3, mRNA. pcDNA3.1+-DYK On-demand TBD $219.00
OHu40509 XM_006715234 PREDICTED: Homo sapiens runt-related transcription factor 2 (RUNX2), transcript variant X4, mRNA. pcDNA3.1+-DYK On-demand TBD $159.00
OHu21119C NM_001278478 Homo sapiens runt-related transcription factor 2 (RUNX2), transcript variant 4, mRNA. Customized vector On-demand TBD $269.00
OHu22430C NM_001015051 Homo sapiens runt-related transcription factor 2 (RUNX2), transcript variant 2, mRNA. Customized vector On-demand TBD $269.00
OHu22872C NM_001024630 Homo sapiens runt-related transcription factor 2 (RUNX2), transcript variant 1, mRNA. Customized vector On-demand TBD $269.00
OHu40506C XM_006715231 PREDICTED: Homo sapiens runt-related transcription factor 2 (RUNX2), transcript variant X1, mRNA. Customized vector On-demand TBD $269.00
OHu40507C XM_006715232 PREDICTED: Homo sapiens runt-related transcription factor 2 (RUNX2), transcript variant X2, mRNA. Customized vector On-demand TBD $269.00
OHu40508C XM_006715233 PREDICTED: Homo sapiens runt-related transcription factor 2 (RUNX2), transcript variant X3, mRNA. Customized vector On-demand TBD $269.00
OHu40509C XM_006715234 PREDICTED: Homo sapiens runt-related transcription factor 2 (RUNX2), transcript variant X4, mRNA. Customized vector On-demand TBD $209.00

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Gene Symbol RUNX2
Entrez Gene ID 860
Full Name runt-related transcription factor 2
Synonyms AML3, CBF-alpha-1, CBFA1, CCD, CCD1, CLCD, OSF-2, OSF2, PEA2aA, PEBP2aA
General protein information
Preferred Names
runt-related transcription factor 2
Names
runt-related transcription factor 2
PEA2-alpha A
PEBP2-alpha A
oncogene AML-3
acute myeloid leukemia 3 protein
SL3-3 enhancer factor 1 alpha A subunit
osteoblast-specific transcription factor 2
SL3/AKV core-binding factor alpha A subunit
core-binding factor, runt domain, alpha subunit 1
polyomavirus enhancer-binding protein 2 alpha A subunit
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6p21

Summary This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Jul 2008].
Disorder

MIM: 600211

Cleidocranial dysplasia, 119600 (3); Dental anomalies, isolated (3)

mRNA Protein Product Sequence Price Select
NM_001015051, 226442790 NP_001015051, 226442791 runt-related transcription factor 2 isoform b ORF Sequence $550.00
NM_001024630, 226442782 NP_001019801, 226442783 runt-related transcription factor 2 isoform a ORF Sequence $550.00
NM_001278478, 511093988 NP_001265407, 511093989 runt-related transcription factor 2 isoform d ORF Sequence $550.00
XM_006715231, 578812016 XP_006715294, 578812017 runt-related transcription factor 2 isoform X1 ORF Sequence $550.00
XM_006715232, 578812018 XP_006715295, 578812019 runt-related transcription factor 2 isoform X2 ORF Sequence $550.00
XM_006715233, 578812020 XP_006715296, 578812021 runt-related transcription factor 2 isoform X3 ORF Sequence $550.00
XM_006715234, 578812022 XP_006715297, 578812023 runt-related transcription factor 2 isoform X4 ORF Sequence $300.00
KEGG
hsa05202Transcriptional misregulation in cancer
WikiPathways
WP138Androgen receptor signaling pathway
WP366TGF-beta Receptor Signaling Pathway
WP474Endochondral Ossification
WP560TGF Beta Signaling Pathway
WP363Wnt Signaling Pathway NetPath
WP1425BMP signalling and regulation
WP2332Interleukin-11 Signaling Pathway
Pathway Interaction Database
smad2_3nuclearpathwayRegulation of nuclear SMAD2/3 signaling
rb_1pathwayRegulation of retinoblastoma protein
fgf_pathwayFGF signaling pathway
hes_heypathwayNotch-mediated HES/HEY network
Reactome
REACT_12627Generic Transcription Pathway
REACT_71Gene Expression
REACT_118713YAP1- and WWTR1 (TAZ)-stimulated gene expression
Homo sapiens (human)RUNX2NP_001019801.3
Pan troglodytes (chimpanzee)RUNX2XP_001142127.2
Macaca mulatta (Rhesus monkey)RUNX2XP_001100855.1
Bos taurus (cattle)RUNX2XP_002697308.2
Mus musculus (house mouse)Runx2NP_001139510.1
Rattus norvegicus (Norway rat)Runx2NP_001265412.1
Gallus gallus (chicken)RUNX2NP_989459.1
Danio rerio (zebrafish)runx2aNP_998023.1
Xenopus (Silurana) tropicalis (western clawed frog)runx2NP_001128588.1
Process
IDNameEvidence
GO:0001503ossificationTAS
GO:0001649osteoblast differentiationIEP
GO:0001649osteoblast differentiationTAS
GO:0001958endochondral ossificationIEA
GO:0002051osteoblast fate commitmentIEA
GO:0002063chondrocyte developmentIEA
GO:0002076osteoblast developmentIEA
GO:0006367transcription initiation from RNA polymerase II promoterTAS
GO:0008284positive regulation of cell proliferationIEA
GO:0010467gene expressionTAS
GO:0030217T cell differentiationIEA
GO:0030509BMP signaling pathwayISS
GO:0032332positive regulation of chondrocyte differentiationIEA
GO:0035115embryonic forelimb morphogenesisIEA
GO:0040036regulation of fibroblast growth factor receptor signaling pathwayIEA
GO:0042475odontogenesis of dentin-containing toothIEA
GO:0042487regulation of odontogenesis of dentin-containing toothIEA
GO:0045669positive regulation of osteoblast differentiationIEA
GO:0045879negative regulation of smoothened signaling pathwayIEA
GO:0045892negative regulation of transcription, DNA-templatedIDA
GO:0045893positive regulation of transcription, DNA-templatedIDA
GO:0048469cell maturationIEA
GO:0048701embryonic cranial skeleton morphogenesisIEA
GO:0048863stem cell differentiationIEA
GO:0071773cellular response to BMP stimulusISS
GO:1901522positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulusISS
Component
IDNameEvidence
GO:0000790nuclear chromatinISS
GO:0005634nucleusIDA
GO:0005667transcription factor complexIEA
GO:0005730nucleolusIDA
GO:0005737cytoplasmIEA
Function
IDNameEvidence
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingIEA
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIEA
GO:0003682chromatin bindingIEA
GO:0003700sequence-specific DNA binding transcription factor activityNAS
GO:0005515protein bindingIPI
GO:0005524ATP bindingIEA
GO:0019904protein domain specific bindingIEA
GO:0043425bHLH transcription factor bindingIEA
GO:0070491repressing transcription factor bindingIEA
GeneCards RUNX2
UniProt Q13950, Q32MY8, F8W8U5
Vega OTTHUMG00000014774
MIM 600211
Ensembl ENSG00000124813
HGNC 10472
HPRD 02566

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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