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RUNX2 runt-related transcription factor 2 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001015051 Homo sapiens runt-related transcription factor 2 (RUNX2), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand TBD TBD
NM_001024630 Homo sapiens runt-related transcription factor 2 (RUNX2), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand TBD TBD
NM_004348 Homo sapiens runt-related transcription factor 2 (RUNX2), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand TBD TBD

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Related Services

Gene Symbol RUNX2
Entrez Gene ID 860
Full Name runt-related transcription factor 2
Synonyms AML3, CBFA1, CCD, CCD1, MGC120022, MGC120023, OSF-2, OSF2, PEA2aA, PEBP2A1, PEBP2A2, PEBP2aA, PEBP2aA1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6p21

Summary This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Jul 2008].
Disorder

MIM: 600211

Cleidocranial dysplasia, 119600 (3); Dental anomalies, isolated (3)

mRNA Protein Product Sequence Price Select
NM_001015051, 226442790 NP_001015051, 226442791 runt-related transcription factor 2 isoform b ORF Sequence $550.00
NM_001024630, 226442782 NP_001019801, 226442783 runt-related transcription factor 2 isoform a ORF Sequence $550.00
NM_004348, 66934968 NP_004339, 66934969 runt-related transcription factor 2 isoform c ORF Sequence $550.00
KEGG
hsa05202Transcriptional misregulation in cancer
WikiPathways
WP474Endochondral Ossification
WP366TGF-beta Receptor Signaling Pathway
WP138Androgen receptor signaling pathway
WP363Wnt Signaling Pathway NetPath
WP2332Interleukin-11 Signaling Pathway
WP1425BMP signalling and regulation
WP560TGF Beta Signaling Pathway
Pathway Interaction Database
rb_1pathwayRegulation of retinoblastoma protein
fgf_pathwayFGF signaling pathway
hes_heypathwayNotch-mediated HES/HEY network
smad2_3nuclearpathwayRegulation of nuclear SMAD2/3 signaling
Reactome
REACT_118713YAP1- and WWTR1 (TAZ)-stimulated gene expression
REACT_71Gene Expression
REACT_12627Generic Transcription Pathway
Homo sapiens (human)RUNX2NP_001019801.3
Pan troglodytes (chimpanzee)RUNX2XP_001142127.2
Macaca mulatta (Rhesus monkey)RUNX2XP_001100855.1
Bos taurus (cattle)RUNX2XP_002697308.1
Mus musculus (house mouse)Runx2NP_001139510.1
Rattus norvegicus (Norway rat)Runx2NP_445922.1
Gallus gallus (chicken)RUNX2NP_989459.1
Danio rerio (zebrafish)runx2aNP_998023.1
Caenorhabditis elegansrnt-1NP_491679.1
GeneCards RUNX2
UniProt Q13950
MIM 600211
Ensembl ENSG00000124813
HGNC 10472
HPRD 02566

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
runt-related transcription factor 2
Names
runt-related transcription factor 2
PEA2-alpha A
PEBP2-alpha A
oncogene AML-3
acute myeloid leukemia 3 protein
SL3-3 enhancer factor 1 alpha A subunit
osteoblast-specific transcription factor 2
SL3/AKV core-binding factor alpha A subunit
core-binding factor, runt domain, alpha subunit 1
polyomavirus enhancer-binding protein 2 alpha A subunit

Interactant



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