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TP63 tumor protein p63 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001114978 Homo sapiens tumor protein p63 (TP63), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_001114979 Homo sapiens tumor protein p63 (TP63), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_001114980 Homo sapiens tumor protein p63 (TP63), transcript variant 4, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_001114981 Homo sapiens tumor protein p63 (TP63), transcript variant 5, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_001114982 Homo sapiens tumor protein p63 (TP63), transcript variant 6, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_003722 Homo sapiens tumor protein p63 (TP63), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_005247843 PREDICTED: Homo sapiens tumor protein p63 (TP63), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_005247844 PREDICTED: Homo sapiens tumor protein p63 (TP63), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_005247846 PREDICTED: Homo sapiens tumor protein p63 (TP63), transcript variant X4, mRNA. GenEZ ORF Cloning On-demand $699.00 18

*Business Day

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Gene Symbol TP63
Entrez Gene ID 8626
Full Name tumor protein p63
Synonyms AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L
General protein information
Preferred Names
tumor protein 63
Names
tumor protein 63
CUSP
transformation-related protein 63
tumor protein p53-competing protein
amplified in squamous cell carcinoma
chronic ulcerative stomatitis protein
keratinocyte transcription factor KET
tumor protein p63 deltaN isoform delta
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

3

3q28

Summary This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined. [provided by RefSeq, Jul 2008].
Disorder

MIM: 603273

Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome

mRNA Protein Product Sequence Price Select
NM_001114978, 169234656 NP_001108450, 169234657 tumor protein 63 isoform 2 ORF Sequence $550.00
NM_001114979, 169234658 NP_001108451, 169234659 tumor protein 63 isoform 3 ORF Sequence $550.00
NM_001114980, 169234660 NP_001108452, 169234661 tumor protein 63 isoform 4 ORF Sequence $700.00
NM_001114981, 169234662 NP_001108453, 169234663 tumor protein 63 isoform 5 ORF Sequence $550.00
NM_001114982, 169234664 NP_001108454, 169234665 tumor protein 63 isoform 6 ORF Sequence $400.00
NM_003722, 169234655 NP_003713, 31543818 tumor protein 63 isoform 1 ORF Sequence $700.00
XM_005247843, 530375420 XP_005247900, 530375421 tumor protein 63 isoform X1 ORF Sequence $700.00
XM_005247844, 578807834 XP_005247901, 530375423 tumor protein 63 isoform X2 ORF Sequence $700.00
XM_005247846, 530375426 XP_005247903, 530375427 tumor protein 63 isoform X4 ORF Sequence $550.00
KEGG
hsa05206MicroRNAs in cancer
WikiPathways
WP254Apoptosis
WP1742TP53 network
Pathway Interaction Database
p53downstreampathwayDirect p53 effectors
Homo sapiens (human)TP63NP_003713.3
Pan troglodytes (chimpanzee)TP63XP_001160376.1
Macaca mulatta (Rhesus monkey)TP63XP_001092093.1
Canis lupus familiaris (dog)TP63XP_850415.3
Bos taurus (cattle)TP63NP_001178266.1
Mus musculus (house mouse)Trp63NP_001120731.1
Rattus norvegicus (Norway rat)Tp63NP_062094.1
Gallus gallus (chicken)TP63NP_989682.1
Danio rerio (zebrafish)tp63NP_689454.1
Xenopus (Silurana) tropicalis (western clawed frog)tp63XP_002934096.2
Process
IDNameEvidence
GO:0000122negative regulation of transcription from RNA polymerase II promoterIBA
GO:0001501skeletal system developmentIEA
GO:0001736establishment of planar polarityIEA
GO:0002053positive regulation of mesenchymal cell proliferationIEA
GO:0002064epithelial cell developmentIEA
GO:0006338chromatin remodelingIEA
GO:0006351transcription, DNA-templatedIEA
GO:0006915apoptotic processTAS
GO:0006974cellular response to DNA damage stimulusIDA
GO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorIBA
GO:0007219Notch signaling pathwayIEA
GO:0007499ectoderm and mesoderm interactionIEA
GO:0007569cell agingIEA
GO:0009954proximal/distal pattern formationIEA
GO:0010165response to X-rayIBA
GO:0010259multicellular organismal agingIEA
GO:0010332response to gamma radiationIBA
GO:0010481epidermal cell divisionIEA
GO:0010482regulation of epidermal cell divisionISS
GO:0030216keratinocyte differentiationIEA
GO:0030326embryonic limb morphogenesisIEA
GO:0030859polarized epithelial cell differentiationIEA
GO:0031069hair follicle morphogenesisIEA
GO:0031571mitotic G1 DNA damage checkpointIBA
GO:0034644cellular response to UVIBA
GO:0036342post-anal tail morphogenesisIEA
GO:0042475odontogenesis of dentin-containing toothIEA
GO:0042771intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorIBA
GO:0043066negative regulation of apoptotic processIEA
GO:0043523regulation of neuron apoptotic processIBA
GO:0043616keratinocyte proliferationIEA
GO:0045617negative regulation of keratinocyte differentiationIEA
GO:0045669positive regulation of osteoblast differentiationIMP
GO:0045747positive regulation of Notch signaling pathwayIDA
GO:0045892negative regulation of transcription, DNA-templatedIDA
GO:0045893positive regulation of transcription, DNA-templatedIDA
GO:0045893positive regulation of transcription, DNA-templatedNAS
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
GO:0048485sympathetic nervous system developmentIEA
GO:0048745smooth muscle tissue developmentIEA
GO:0048807female genitalia morphogenesisIEA
GO:0051289protein homotetramerizationIPI
GO:0051402neuron apoptotic processIEA
GO:0060157urinary bladder developmentIEA
GO:0060197cloacal septationIEA
GO:0060513prostatic bud formationIEA
GO:0060529squamous basal epithelial stem cell differentiation involved in prostate gland acinus developmentIEA
GO:0061436establishment of skin barrierISS
GO:1902808positive regulation of cell cycle G1/S phase transitionIMP
GO:2000271positive regulation of fibroblast apoptotic processIDA
GO:2000381negative regulation of mesoderm developmentIEA
GO:2000773negative regulation of cellular senescenceIMP
GO:2001235positive regulation of apoptotic signaling pathwayIEA
Component
IDNameEvidence
GO:0000785chromatinIBA
GO:0000790nuclear chromatinIDA
GO:0005634nucleusIDA
GO:0005634nucleusNAS
GO:0005654nucleoplasmIDA
GO:0005667transcription factor complexIBA
GO:0005730nucleolusIDA
GO:0005737cytoplasmIDA
GO:0005829cytosolIBA
GO:0030425dendriteIBA
Function
IDNameEvidence
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIEA
GO:0002039p53 bindingIBA
GO:0003677DNA bindingNAS
GO:0003682chromatin bindingIBA
GO:0003682chromatin bindingIDA
GO:0003684damaged DNA bindingIBA
GO:0003690double-stranded DNA bindingIBA
GO:0003700sequence-specific DNA binding transcription factor activityIBA
GO:0005515protein bindingIPI
GO:0042802identical protein bindingIPI
GO:0043565sequence-specific DNA bindingIBA
GO:0044212transcription regulatory region DNA bindingIEA
GO:0046872metal ion bindingIEA
GO:0050699WW domain bindingIPI
GeneCards TP63
UniProt Q9H3D4
Vega OTTHUMG00000156313
MIM 603273
Ensembl ENSG00000073282
HGNC 15979
HPRD 04469

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the TP63 gene?

The TP63 gene provides instructions for making a protein called tumor protein p63 (also known simply as p63). The p63 protein functions as a transcription factor, which means it attaches (binds) to certain regions of DNA and controls the activity of particular genes.

The p63 protein interacts with other proteins to turn many different genes on and off at different times. The action of p63 helps regulate numerous cell activities, including cell growth and division (proliferation), cell maintenance, the process by which cells mature to carry out specific functions (differentiation), the ability of cells to stick to one another (cell adhesion), and the orderly self-destruction of cells (apoptosis).

The p63 protein plays a critical role in early development. It is especially important for the normal development of ectodermal structures, such as the skin, hair, teeth, and nails. Studies suggest that it also plays essential roles in the development of the limbs, facial features, urinary system, and other organs and tissues. In addition to its roles in development, the p63 protein appears to be necessary for the maintenance of various cells and tissues later in life.

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