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TP63 tumor protein p63 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001114978 Homo sapiens tumor protein p63 (TP63), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_001114979 Homo sapiens tumor protein p63 (TP63), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_001114980 Homo sapiens tumor protein p63 (TP63), transcript variant 4, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_001114981 Homo sapiens tumor protein p63 (TP63), transcript variant 5, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_001114982 Homo sapiens tumor protein p63 (TP63), transcript variant 6, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_003722 Homo sapiens tumor protein p63 (TP63), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $849.00 20

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Gene Symbol TP63
Entrez Gene ID 8626
Full Name tumor protein p63
Synonyms AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

3

3q28

Summary This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined. [provided by RefSeq, Jul 2008].
Disorder

MIM: 603273

Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome

mRNA Protein Product Sequence Price Select
NM_001114978, 169234656 NP_001108450, 169234657 tumor protein 63 isoform 2 ORF Sequence $550.00
NM_001114979, 169234658 NP_001108451, 169234659 tumor protein 63 isoform 3 ORF Sequence $550.00
NM_001114980, 169234660 NP_001108452, 169234661 tumor protein 63 isoform 4 ORF Sequence $700.00
NM_001114981, 169234662 NP_001108453, 169234663 tumor protein 63 isoform 5 ORF Sequence $550.00
NM_001114982, 169234664 NP_001108454, 169234665 tumor protein 63 isoform 6 ORF Sequence $400.00
NM_003722, 169234655 NP_003713, 31543818 tumor protein 63 isoform 1 ORF Sequence $700.00
WikiPathways
WP1742TP53 network
WP254Apoptosis
Pathway Interaction Database
p53downstreampathwayDirect p53 effectors
Homo sapiens (human)TP63NP_003713.3
Pan troglodytes (chimpanzee)TP63XP_001160376.1
Macaca mulatta (Rhesus monkey)TP63XP_001092093.1
Canis lupus familiaris (dog)TP63XP_850415.2
Bos taurus (cattle)TP63NP_001178266.1
Mus musculus (house mouse)Trp63NP_001120731.1
Rattus norvegicus (Norway rat)Tp63NP_062094.1
Gallus gallus (chicken)TP63NP_989682.1
Danio rerio (zebrafish)tp63NP_694518.1
GeneCards TP63
PDB 4A9Z, 3QYN, 2Y9T, 3ZY0, 3ZY1, 3US0, 2Y9U, 2RMN, 1RG6, 3US2, 3US1, 3QYM
UniProt Q9H3D4
MIM 603273
Ensembl ENSG00000073282
HGNC 15979
HPRD 04469

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
tumor protein 63
Names
tumor protein 63
CUSP
transformation-related protein 63
tumor protein p53-competing protein
amplified in squamous cell carcinoma
chronic ulcerative stomatitis protein
keratinocyte transcription factor KET
tumor protein p63 deltaN isoform delta

Interactant



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